1,25(OH)2 vitamin D3 stimulates membrane phosphoinositide turnover, activates protein kinase C, and increases cytosolic calcium in rat colonic epithelium

Journal of Clinical Investigation

Volumn 85, Issue 4, 1990, Pages 1296-1303

  Wali, Ramesh K ^a   Baum, Charles L ^a   Sitrin, Michael D ^a   Brasitus, Thomas A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

1,25(OH)2 vitamin D3; Diacylglycerol; Intracellular calcium; Phosphoinositide metabolism; Protein kinase C

Indexed keywords

CALCITRIOL; PHOSPHATIDYLINOSITIDE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; COLON MUCOSA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CALCITRIOL; CALCIUM; CELL MEMBRANE; COLON; DIGLYCERIDES; DNA; ENZYME ACTIVATION; EPITHELIUM; IN VITRO; PHOSPHATIDYLINOSITOLS; PROTEIN KINASE C; RATS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025323383     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI114567     Document Type: Article

References (58)

1. Norman, A. W., J. Roth, and L. Orci. 1982. The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr. Rev. 3:331-366.
2. 3 on human cancer cells in vitro. J. Steroid Biochem. 27:825-828.
3. Koeffler, H. P. 1985. Vitamin D: myeloid differentiation and proliferation. Haematol. Blood Transfus. 29:409-417.
4. 3 receptor and induction of differentiation by the hormone. J. Steroid Biochem. 29:265-270.
5. Wargovich, M. J., and P. H. Lointier. 1987. Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line. Can. J. Physiol. Pharmacol. 65:472-477.
6. Birge, S. J., and D. H. Alpers. 1973. Stimulation of intestinal mucosal proliferation by vitamin D. Gastroenterology. 64:977-982.
7. Hylander, E., K. Ladefauged, and S. Jarnum. 1980. The importance of the colon in calcium absorption following small intestinal resection. Scand. J. Gastroenterol. 15:55-60.
8. 3 on calcium absorption in the colon of healthy humans. Am. J. Physiol. 247:G189-192.
9. Garland, C. F., and F. C. Garland. 1980. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol. 9:227-231.
10. Garland, C., E. Barren-Connor, A. H. Rossott, R. B. Shekelle, M. H. Criqui, and O. Paul. 1985. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet i:307-309.
11. 3 receptors: gene regulation and genetic circuiting. FASEB (Fed. Am. Soc. Exp. Biol.) J. 2:3043-3053.
12. 3. Endocrinology. 123:1778-1782.
13. 3. Fed. Proc. 41:72-77.
14. Kurnik, B. R. C., M. Huskey, D. Hagerty, and K. A. Hruska. 1986. Vitamin D metabolites stimulate phosphatidylcholine transfer to renal brush-border membranes. Biochim. Biophys. Acta. 858:47-55.
15. Brasitus, T. A., P. K. Dudeja, B. Eby, and K. Lau. 1986. Correction by 1,25-dihydroxycholecalciferol of the abnormal fluidity and lipid composition of enterocyte brush border membranes in vitamin D deprived rats. J. Biol. Chem. 261:16404-16409.
16. Craven, P. A., J. Pfanstiel, and F. R. DeRubertis. 1987. Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids. J. Clin. Invest. 79:532-541.
17. Craven, P. A., and F. R. DeRubertis. 1988. Role of activation of protein kinase C in the stimulation of colonie epithelial proliferation by unsaturated fatty acids. Gastroenterology. 95:676-685.
18. Craven, P. A., J. Pfanstiel, and F. R. DeRubertis. 1986. Role of reactive oxygen in bile salt stimulation of colonie epithelial proliferation. J. Clin. Invest. 77:850-859.
19. Roediger, W. E. W. 1982. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology. 83:424-429.
20. Kraft, A. S., W. B. Anderson, H. C. Cooper, and J. J. Sando. 1982. Decrease in cytosolic calcium/phospholipid dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells. J. Biol. Chem. 257:13193-13196.
21. Snyder, F. 1976. Chromatographic analysis of alkyl and alk-1-enyl ether lipids and their derivates. In Lipid Chromatographic Analysis. Volume 1. G. V. Marinetti, editor. Marcel Dekker, Inc., New York. 116-148.
22. Folch, J., M. Lees, and G. H. Sloane-Stanley. 1957. A simple method for the isolation and purification of the total lipids from the animal tissues. J. Biol. Chem. 227:497-509.
23. Bartlett, G. R. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234:466-468.
24. Preiss, J., C. R. Loomis, R. W. Bishop, R. Stein, J. E. Niedel, and R. M. Bell. 1986. Quantitative measurement of Sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis transformed normal rat kidney cells. J. Biol. Chem. 261:8597-8600.
25. MacDonald, M. L., K. F. Mack, C. N. Richardson, and J. A. Glomset. 1988. Regulation of diacylglycerol kinase reaction in Swiss 3T3 cells. J. Biol. Chem. 263:1575-1583.
26. Wright, T. M., L. A. Rangan, H. S. Shin, and D. M. Raben. 1988. Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. J. Biol. Chem. 263:9374-9380.
27. Muldoon, L. L., K. D. Rodland, M. L. Forsythe, and B. E. Magun. 1989. Stimulation of phosphatidylinositol hydrolysis, diacylglycerol release and gene expression in response to endothelin, a potent new agonist for fibroblast and smooth muscle cells. J. Biol. Chem. 264:8529-8536.
28. Downes, C. P., M. C. Mussat, and R. H. Michell. 1982. The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane. Biochem. J. 203:169-177.
29. VanDongen, C. J., H. Zwiers, and W. H. Gispen. 1985. Microdetermination of phosphoinositides in a single extract. Anal. Biochem. 144:104-109.
30. Brasitus, T. A. 1983. Lipid dynamics and protein-lipid interactions in rat colonic epithelial cell basolateral membrane. Biochim. Biophys. Acta. 732:20-30.
31. Sage, S. O., and T. J. Rink. 1987. The kinetics of changes in intracellular calcium concentration in Fura-2-loaded human platelets. J. Biol. Chem. 262:16364-16369.
32. +2 indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
33. Verbin, R. S., and E. Farber. 1967. Effect of cycloheximide on the cell cycle of the crypts of the small intestine of the rat. J. Cell Biol. 35:649-658.
34. Burton, K. 1956. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62:315-322.
35. Snedcor, G. W., and G. W. Cochran. 1976. Samplng from a normally distributed population. In Statistical Methods. Iowa State University Press, Ames, IA. 32-66.
36. Norman, A. W., and F. P. Ross. 1979. Vitamin D seco-steroids: unique molecules with both hormone and possible membranophilic properties. Life Sci. 24:759-770.
37. 3 receptor in human target cells. Endocrinology. 122:1613-1621.
38. 3 increases intracellular calcium in human keratinocytes by stimulating phosphatidylinositol turnover. J. Bone Miner. Res. 2(Suppl. 1):76. (Abstr.)
39. 1 pituitary cells. J. Clin. Invest. 81:661-668.
40. Baran, D. T., and A. M. Kelly. 1988. Lysophosphatidylinositol: a potential mediator of 1,25-dihydroxyvitamin D-induced increments in hepatocyte cytosolic calcium. Endocrinology. 122:930-934.
41. Alkon, D. L., and H. Rasmussen. 1988. A spacial-temporal model of cell activation. Science (Wash. DC). 239:998-1005.
42. Kuno, M., and P. Gardnes. 1987. Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocyte. Nature (Lond.). 326:301-304.
43. Kikkawa, U., and Y. Nishizuka. 1986. The role of protein kinase C in transmembrane signaling. Annu. Rev. Cell Biol. 2:149-178.
44. Melloni, E., S. Pontremoli, M. Michetti, O. Sacco, B. Sparatore, and B. L. Horecker. 1986. The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid. J. Biol. Chem. 261:4101-4108.
45. Nishizuka, Y. 1984. The role of protein kinase C in cell surface signal transduction and tumor production. Nature (Lond.). 308:693-698.
46. Weinstein, B. 1988. The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment-twenty-seventh G. H. A. Clowes Memorial Award Lecture. Cancer Res. 48:4135-4143.
47. 3 enhances phorbol ester-stimulated differentiation and protein kinase C-dependent substrate phosphorylation activity in the U937 human monoblastoid cell. Endocrinology. 121:1654-1660.
48. 3) acts through protein kinase C to induce HL-60 cell differentiation. Fed. Proc. 46:603. (Abstr.)
49. Mezzetti, O., G. P. Bagnara, M. C. Monti, L. P. Casolo, L. Bonsi, and M. A. Brunelli. 1987. Phorbol esters, but not the hormonal form of vitamin D, induce changes in protein kinase C during differentiation of human histiocytic lymphoma cell line (U-937). Life Sci. 40:2111-2117.
50. 3 of chemically induced transformation of BALB 3T3 cells without induction of ornithine decarboxylase or activation of protein kinase C. Cancer Res. 46:604-610.
51. Berridge, M. J., and R. F. Irvine. 1984. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (Lond.). 312:315-321.
52. Baran, D. T., and M. L. Milne. 1986. 1,25dihydroxyvitamin D increases hepatocyte cytosolic calcium levels. J. Clin. Invent. 77:1622-1626.
53. 3 on cytosolic calcium in dispersed parathyroid cell. Kidney Int. 33:850-854.
54. 3 metabolites on cytosolic free calcium in confluent mouse osteoblasts. J. Biol. Chem. 262:13168-13173.
55. 3. Endocrinology. 118:2300-2304.
56. 3 are suppressed by calcium channel blockers. Endocrinology. 120:1858-1864.
57. Nemere, I., and C. M. Szego. 1981. Early actions of parathyroid hormone and 1,25-dihydroxycholecalciferol on isolated epithelial cells from rat intestinel. 1. Limited lysosomal enzyme release and calcium uptake. Endocrinology. 108:1450-1462.
58. Putkey, J. A., A. M. Spielvogel, R. D. Sauerheber, C. S. Dunlap, and A. W. Norman. 1982. Vitamin D-mediated intestinal calcium transport. Effects of essential fatty acid deficiency and spin label studies of enterocyte membrane lipid fluidity. Biochim. Biophys. Acta. 588:177-190.