The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo

British Journal of Pharmacology

Volumn 99, Issue 4, 1990, Pages 667-672

  Lewis, D I ^a   Coote, J H ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 2 METHYLSEROTONIN; 5 CARBAMOYLTRYPTAMINE; ALPHA METHYLSEROTONIN; GLUTAMIC ACID; HOMOCYSTEIC ACID; KETANSERIN; NORADRENALIN; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; TROPISETRON;

ANIMAL EXPERIMENT; ARTICLE; MALE; MICROIONTOPHORESIS; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; RAT; SPINAL CORD; SYMPATHETIC NERVE CELL; TOPICAL DRUG ADMINISTRATION;

EID: 0025317646     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1990.tb12987.x     Document Type: Article

References (28)

1. BACON, S.J. & SMITH, D. (1988). Preganglionic sympathetic neurones innervating the rat adrenal medulla: immunocytochemical evidence of synaptic input from nerve terminals containing substance P, GABA or 5‐hydroxytryptamine. J. Auton. Nerv. Syst., 24, 97–122.
2. BRADLEY, P.B., ENGEL, G., FENIUK, W., FOZARD, J.R., HUMPHREY, P.P.A., MIDDLEMISS, D.N., MYLECHARANE, E.J., RICHARDSON, B.P. & SAXENA, P.R. (1986). Proposals for the classification and nomenclature of functional receptors for 5‐hydroxytryptamine. Neuropharmacology, 25, 563–576.
3. COHEN, M.L., KURZ, K.D., MASON, N.R., FULLER, R.W., MARZONI, G.P. & GARBRECHT, W.L. (1985). Pharmacological activity of the isomers of LY 53857, potent and selective 5‐HT 2 receptor antagonists. J. Pharmacol. Exp. Ther., 235, 319–323.
4. CONNELL, L.A. & WALLIS, D.I. (1988). Responses to 5‐hydroxytryptamine evoked in the hemisected spinal cord of the neonate rat. Br. J. Pharmacol., 94, 1101–1114.
5. COOTE, J.H. & LEWIS, D.I. (1989a). Failure of ketanserin to selectively block the excitatory action of 5‐HT on rat sympathetic preganglionic neurones. Br. J. Pharmacol., 98, 640P.
6. COOTE, J.H. & LEWIS, D.I. (1989b). The action of catecholamines on sympathetic preganglionic neurones in the T 2 segment of the anaesthetised adult rat spinal cord. J. Physiol., 416, 17P.
7. COOTE, J.H. (1988). The organisation of cardiovascular neurones in the spinal cord. Rev. Physiol. Biochem. Pharmacol., 110, 147–285.
8. COOTE, J.H., MacLEOD, V.H., FLEETWOOD‐WALKER, S.M. & GILBEY, M.P. (1981). The response of individual sympathetic preganglionic neurones to microiontophoretically applied endogenous monoamines. Brain Res., 215, 135–145.
9. DAHLSTROM, A. & FUXE, K. (1965). Evidence for the existence of monoamine neurones in the central nervous system. Acta Physiol. Scand., 64, suppl. 247 5–36.
10. DAVIES, M., WILKINSON, L.S. & ROBERTS, M.H.T. (1988a). Evidence for excitatory 5‐HT 2 receptors on rat brainstem neurones. Br. J. Pharmacol., 94, 483–491.
11. DAVIES, M., WILKINSON, L.S. & ROBERTS, M.H.T. (1988b). Evidence for depressant 5‐HT 1 like receptors on rat brainstem neurones. Br. J. Pharmacol., 94, 492–499.
12. DUN, N.J. & MO, N. (1988). In vitro effects of substance P on neonatal rat sympathetic preganglionic neurones. J. Physiol., 399, 321–333.
13. DUN, N.J. & MO, N. (1989). Inhibitory postsynaptic potentials in neonatal rat sympathetic preganglionic neurones in vitro. J. Physiol., 410, 267–281.
14. GILBEY, M.P., COOTE, J.H., MacLEOD, V.H. & PETERSON, D.F. (1981). Inhibition of sympathetic activity by stimulation in the raphe nuclei and the role of 5‐HT in this effect. Brain Res., 226, 131–142.
15. GILBEY, M.P., PETERSON, D.F. & COOTE, J.H. (1982). Some characteristics of sympathetic preganglionic neurones in the rat. Brain Res., 241, 43–48.
16. HUMPHREY, P.P.A. (1984). Peripheral 5‐hydroxytryptamine receptors and their classification. Neuropharmacology, 23, 1503–1510.
17. KADZIELAWA, K. (1983). Antagonism of the excitation effects of 5‐hydroxytryptamine on sympathetic preganglionic neurones and neurones activated by visceral afferents. Neuropharmacology, 22, 19–27.
18. LAKOSKI, J.M. & AGHAJANIAN, G.K. (1985). Effects of ketanserin on neural response to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology, 24, 265–273.
19. LEYSEN, J.E., AWOUTERS, F., KENNIS, L., LADURON, P.M., VANDENBERK, J. & JANSSEN, P.A.J. (1981). Receptor binding profile of R 41 468, a novel antagonist at 5‐HT 2 receptors. Life Sci., 28, 1015–1022.
20. LOEWY, A.D. & McKELLAR, S. (1981). Serotonergic projections from ventral medulla to the intermediolateral cell column in the rat. Brain Res., 211, 146–152.
21. McCALL, R.B. (1983). Serotonergic excitation of sympathetic preganglionic neurones: a microiontophoretic study. Brain Res., 289, 121–127.
22. McCALL, R.B. (1988). Effects of putative neurotransmitters on sympathetic preganglionic neurones. Ann. Rev. Physiol., 50, 553–564.
23. MIYAZAKI, T., COOTE, J.H. & DUN, N.J. (1989). Excitation and inhibitory effects of epinephrine on neonatal rat sympathetic preganglionic neurones. Brain Res., 497, 108–116.
24. RICHARDSON, B.P., ENGEL, G., DONATSCH, P. & STADLER, P.A. (1985). Identification of serotonin M‐receptor subtypes and their specific blockade by a new class of drugs. Nature, 316, 126–131.
25. ROBERTS, M.H.T., DAVIES, M., GIRDLESTONE, D. & FOSTER, G.A. (1988). Effects of 5‐hydroxytryptamine agonists and antagonists on the responses of rat spinal motoneurones to raphe obscurus stimulation. Br. J. Pharmacol., 95, 437–448.
26. SHI, H., LEWIS, D.I. & COOTE, J.H. (1988). Effects of activating spinal alpha‐adrenoreceptors on sympathetic nerve activity in the rat. J. Auton. Nerv. Syst., 23, 69–78.
27. SUPRENANT, A. & CRIST, J. (1988). Electrophysiological characterisation of functionally distinct 5‐hydroxytryptamine receptors on guinea pig submucous plexus. Neurosci., 24, 283–295.
28. YUSOF, A.P.M. & COOTE, J.H. (1988). Excitatory and inhibitory actions of intrathecally administered 5‐hydroxytryptamine on sympathetic nerve activity in the rat. J. Auton. Nerv. Syst., 22, 229–236.