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Volumn 50, Issue 13, 1990, Pages 3838-3842

Combined Modulation of S-Adenosylmethionine Biosynthesis and S-Adenosylhomocysteine Metabolism Enhances Inhibition of Nucleic Acid Methylation and L1210 Cell Growth

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 METHOXY 3 BUTENOIC ACID; 9 (2,3 DIHYDROXY 4 CYCLOPENTENYL)ADENINE; ENZYME INHIBITOR; RADIOISOTOPE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

EID: 0025310205     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (30)

References (41)
  • 1
    • 0344262363 scopus 로고
    • The enzymatic synthesis of 5-adenosyl-L-methionine: mechanism and inhibition
    • Chou, T.-C., Coulter, A. W., Lombardini, J. B., Sufrin, J. R., and Talalay, P. The enzymatic synthesis of 5-adenosyl-L-methionine: mechanism and inhibition. In: F. Salvatore, E. Borek, V. Zappia, H. G. Williams-Ashman, and F. Schlenk (eds.), The Biochemistry of AdenosyImethionine, pp. 18–36. New York: Columbia University Press, 1977.
    • (1977) The Biochemistry of AdenosyImethionine , pp. 18-36
    • Chou, T.-C.1    Coulter, A.W.2    Lombardini, J.B.3    Sufrin, J.R.4    Talalay, P.5
  • 3
    • 0020700003 scopus 로고
    • Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases
    • Lombardini, J. B., and Sufrin, J. R. Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferases. Biochem. Pharmacol., 32: 489–495, 1983.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 489-495
    • Lombardini, J.B.1    Sufrin, J.R.2
  • 4
    • 0020284631 scopus 로고
    • Pharmacological and biochemical aspects of 5-adenosylho-mocysteine and 5-adenosylhomocysteine hydrolase
    • Ueland, P. M. Pharmacological and biochemical aspects of 5-adenosylho-mocysteine and 5-adenosylhomocysteine hydrolase. Pharmacol. Rev., 34: 223–253, 1982.
    • (1982) Pharmacol. Rev. , vol.34 , pp. 223-253
    • Ueland, P.M.1
  • 5
    • 0011880363 scopus 로고
    • Inhibition of 5-adenosylmethionine-dependent transmethylation as an approach to the development of antiviral agents
    • Keller, B. T., and Borchardt, R. T. Inhibition of 5-adenosylmethionine-dependent transmethylation as an approach to the development of antiviral agents. In: E. DeClercq and R. T. Walker (eds.), Antiviral Drug Development: A Multidisciplinary Approach, pp. 123–138. New York: Plenum Press, 1988.
    • (1988) Antiviral Drug Development: A Multidisciplinary Approach , pp. 123-138
    • Keller, B.T.1    Borchardt, R.T.2
  • 6
    • 0023235758 scopus 로고
    • 5-Adenosylhomocysteine hydrolase inhibitors as broad spectrum antiviral agents
    • DeClercq, E. 5-Adenosylhomocysteine hydrolase inhibitors as broad spectrum antiviral agents. Biochem. Pharmacol., 36: 2567–2575, 1987.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2567-2575
    • DeClercq, E.1
  • 7
    • 0019276997 scopus 로고
    • 5′-Terminal cap structure in eukaryotic messenger ribonucleic acid
    • Banerjee, A. K. 5′-Terminal cap structure in eukaryotic messenger ribonucleic acid. Microbiol. Rev., 44: 175–205, 1980.
    • (1980) Microbiol. Rev. , vol.44 , pp. 175-205
    • Banerjee, A.K.1
  • 8
    • 0008471685 scopus 로고
    • Methionine analog inhibitors of 5-adenosylmethionine biosynthesis as potential antitumor agents
    • Sufrin, J. R., Lombardini, J. B., Kramer, D. L., Alks, V., Bernacki, R. J., and Porter, C. W. Methionine analog inhibitors of 5-adenosylmethionine biosynthesis as potential antitumor agents. In: R. T. Borchardt, C. R. Creveling, and P. M. Ueland (eds.), Biological Methylation and Drug Design, pp. 373–384. Clifton, NJ: The Humana Press, 1986.
    • (1986) Biological Methylation and Drug Design , pp. 373-384
    • Sufrin, J.R.1    Lombardini, J.B.2    Kramer, D.L.3    Alks, V.4    Bernacki, R.J.5    Porter, C.W.6
  • 9
    • 0023656525 scopus 로고
    • Relative effects of 5-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis
    • Kramer, D. L., Sufrin, J. R., and Porter, C. W. Relative effects of 5-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesis. Biochem. J., 247: 259–265, 1987.
    • (1987) Biochem. J. , vol.247 , pp. 259-265
    • Kramer, D.L.1    Sufrin, J.R.2    Porter, C.W.3
  • 10
    • 0023905830 scopus 로고
    • Modulation of polyamine-biosynthetic activity by 5-adenosylmethionine depletion
    • Kramer, D. L., Sufrin, J. R., and Porter, C. W. Modulation of polyamine-biosynthetic activity by 5-adenosylmethionine depletion. Biochem. J., 249: 581–588, 1988.
    • (1988) Biochem. J. , vol.249 , pp. 581-588
    • Kramer, D.L.1    Sufrin, J.R.2    Porter, C.W.3
  • 11
    • 0020371915 scopus 로고
    • L-2-Amino-4-methoxy-cw-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of 5-adenosyl-methionine
    • Sufrin, J. R., Lombardini, J. B., and Keith, D. D. L-2-Amino-4-methoxy-cw-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of 5-adenosyl-methionine. Biochem. Biophys. Res. Commun., 106: 251–255, 1982.
    • (1982) Biochem. Biophys. Res. Commun. , vol.106 , pp. 251-255
    • Sufrin, J.R.1    Lombardini, J.B.2    Keith, D.D.3
  • 13
    • 0019508989 scopus 로고
    • Adenosine analogues as substrates and inhibitors of 5-adenosylhomocysteine hydrolase
    • Guranowski, A., Montgomery, J. A., Cantoni, G. L., and Chiang, P. K. Adenosine analogues as substrates and inhibitors of 5-adenosylhomocysteine hydrolase. Biochemistry, 20: 110–115, 1981.
    • (1981) Biochemistry , vol.20 , pp. 110-115
    • Guranowski, A.1    Montgomery, J.A.2    Cantoni, G.L.3    Chiang, P.K.4
  • 14
    • 0018355271 scopus 로고
    • Apparent suicide inactivation of human lymphoblast 5-adenosylhomocysteine hydrolase by 2′-deoxyadenosine and adenine arabi-noside
    • Hershfield, M. D. Apparent suicide inactivation of human lymphoblast 5-adenosylhomocysteine hydrolase by 2′-deoxyadenosine and adenine arabi-noside. A basis for direct toxic effects of analogs of adenosine. J. Biol. Chem., 254: 22–25, 1979.
    • (1979) A basis for direct toxic effects of analogs of adenosine. J. Biol. Chem. , vol.254 , pp. 22-25
    • Hershfield, M.D.1
  • 15
    • 0242651290 scopus 로고
    • Inhibition of 5-adenosyl sulfur amino acid metabolism: periodate-oxidized nucleosides as potent inhibitors of 5-adenosylhomo-cysteine hydrolase
    • Hoffman, J. L. Inhibition of 5-adenosyl sulfur amino acid metabolism: periodate-oxidized nucleosides as potent inhibitors of 5-adenosylhomo-cysteine hydrolase. In: E. Usdin, R. T. Borchardt, and C. R. Creveling (eds.), Transmethylation, pp. 181–186. New York: Elsevier North Holland, 1979.
    • (1979) Transmethylation , pp. 181-186
    • Hoffman, J.L.1
  • 17
    • 0021227696 scopus 로고
    • Neplanocin A, a potent inhibitor of 5-adenosylhomocysteine hydrolase and of Vaccinia virus multiplication in mouse L929 cells
    • Borchardt, R. T., Keller, B. T., and Patel-Thombre, U. Neplanocin A, a potent inhibitor of 5-adenosylhomocysteine hydrolase and of Vaccinia virus multiplication in mouse L929 cells. J. Biol. Chem., 259: 4353–4358, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 4353-4358
    • Borchardt, R.T.1    Keller, B.T.2    Patel-Thombre, U.3
  • 18
    • 0022876004 scopus 로고
    • 3-Deazaneplanocin A: a new inhibitor of 5-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells
    • Glazer, R. I., Knode, M. C., Tseng, C. K. H., Haines, D. R., and Marquez, V. E. 3-Deazaneplanocin A: a new inhibitor of 5-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells. Biochem. Pharmacol., 35: 4523–4527, 1986.
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 4523-4527
    • Glazer, R.I.1    Knode, M.C.2    Tseng, C.K.H.3    Haines, D.R.4    Marquez, V.E.5
  • 19
    • 0023618513 scopus 로고
    • 9-(trans-2′,-trans-3′-Dihydroxycyclopent-4′-enyl)adenine and -3-deazaaden-ine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity
    • Hasobe, M., McKee, J. G., Borcherding, D. R., and Borchardt, R. T. 9-(trans-2′,-trans-3′-Dihydroxycyclopent-4′-enyl)adenine and -3-deazaaden-ine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity. Antimicrob. Agents Chemother., 31: 1849–1851, 1987.
    • (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 1849-1851
    • Hasobe, M.1    McKee, J.G.2    Borcherding, D.R.3    Borchardt, R.T.4
  • 20
    • 0021318876 scopus 로고
    • Metabolic conversion of neplanocin A to 5-neplanocylmethionine by mouse L929 cells
    • Keller, B. T., and Borchardt, R. T. Metabolic conversion of neplanocin A to 5-neplanocylmethionine by mouse L929 cells. Biochem. Biophys. Res. Commun., 120: 131–137, 1984.
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 131-137
    • Keller, B.T.1    Borchardt, R.T.2
  • 21
    • 0021705332 scopus 로고
    • Neplanocin A, a cyclopentenyl analog of adenosine with specificity for inhibiting RNA methylation
    • Glazer, R. I., and Knode, M. C. Neplanocin A, a cyclopentenyl analog of adenosine with specificity for inhibiting RNA methylation. J. Biol. Chem., 259: 12964–12969, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 12964-12969
    • Glazer, R.I.1    Knode, M.C.2
  • 22
    • 0022359593 scopus 로고
    • Purification and characterization of some metabolic effects of 5-neplanocylmethionine
    • Keller, B. T., Clark, R. S., Pegg, A. E., and Borchardt, R. T. Purification and characterization of some metabolic effects of 5-neplanocylmethionine. Mol. Pharmacol., 28: 364–370, 1985.
    • (1985) Mol. Pharmacol. , vol.28 , pp. 364-370
    • Keller, B.T.1    Clark, R.S.2    Pegg, A.E.3    Borchardt, R.T.4
  • 23
    • 0021194198 scopus 로고
    • Effects of adenosine dialdehyde on 5-adenosylhomocysteine hydrolase and 5-adenosylmethionine-dependent transmethylations in mouse L929 cells
    • Bartel, R. A., and Borchardt, R. T. Effects of adenosine dialdehyde on 5-adenosylhomocysteine hydrolase and 5-adenosylmethionine-dependent transmethylations in mouse L929 cells. Mol. Pharmacol., 25: 418–424, 1984.
    • (1984) Mol. Pharmacol. , vol.25 , pp. 418-424
    • Bartel, R.A.1    Borchardt, R.T.2
  • 24
    • 0022538190 scopus 로고
    • Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged 5-adenosylmethionine pools
    • Kajander, E. O., Kubota, M., Can-era, C. J., Montgomery, J. A., and Carson, D. A. Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged 5-adenosylmethionine pools. Cancer Res., 46: 2866–2870, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 2866-2870
    • Kajander, E.O.1    Kubota, M.2    Can-era, C.J.3    Montgomery, J.A.4    Carson, D.A.5
  • 25
    • 0024541377 scopus 로고
    • Basis for resistance to 3-deazaaristeromycin, an inhibitor of 5-adenosylhomocysteine hydrolase, in human B-lymphoblasts
    • Greenberg, M. L., Chaffee, S., and Hershfield, M. S. Basis for resistance to 3-deazaaristeromycin, an inhibitor of 5-adenosylhomocysteine hydrolase, in human B-lymphoblasts. J. Biol. Chem., 264: 795–803, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 795-803
    • Greenberg, M.L.1    Chaffee, S.2    Hershfield, M.S.3
  • 26
    • 0002460125 scopus 로고
    • Inhibitors of 5-adenosylhomocysteine hydrolase and their role in the regulation of biological methylation
    • Cantoni, G. L., Richards, H. H., and Chiang, P. K. Inhibitors of 5-adenosylhomocysteine hydrolase and their role in the regulation of biological methylation. In: E. Usdin, R. T. Borchardt, and C. R. Creveling (eds.), Transmethylation, pp. 155–164. New York: Elsevier North Holland, 1979.
    • (1979) Transmethylation , pp. 155-164
    • Cantoni, G.L.1    Richards, H.H.2    Chiang, P.K.3
  • 27
    • 0023628495 scopus 로고
    • Synthesis of analogues of neplanocin A: utilization of optically active dihydroxycyclopen-tenones derived from carbohydrates
    • Borcherding, D. R., Scholtz, S. A., and Borchardt, R. T. Synthesis of analogues of neplanocin A: utilization of optically active dihydroxycyclopen-tenones derived from carbohydrates. J. Org. Chem., 52: 5457–5461, 1987.
    • (1987) J. Org. Chem. , vol.52 , pp. 5457-5461
    • Borcherding, D.R.1    Scholtz, S.A.2    Borchardt, R.T.3
  • 28
    • 84949380471 scopus 로고
    • An improved synthesis of the biologically active methionine analog, L-2-amino-4-methoxy-ci5-but-3-enoic acid, using an elec-trophilic glycinate synthon
    • Alks, V., and Sufrin, J. R. An improved synthesis of the biologically active methionine analog, L-2-amino-4-methoxy-ci5-but-3-enoic acid, using an elec-trophilic glycinate synthon. Synth. Commun., 19: 1479–1486, 1989.
    • (1989) Synth. Commun. , vol.19 , pp. 1479-1486
    • Alks, V.1    Sufrin, J.R.2
  • 29
    • 0023776651 scopus 로고
    • Effect of DL-a-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei
    • Yarlett, N., and Bacchi, C. J. Effect of DL-a-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei. Mol. Biochem. Parasitol., 27: 1–10, 1988.
    • (1988) Mol. Biochem. Parasitol. , vol.27 , pp. 1-10
    • Yarlett, N.1    Bacchi, C.J.2
  • 30
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium t h iocy ana te-phenol-chloroform extraction
    • Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium t h iocy ana te-phenol-chloroform extraction. Anal. Biochem., 162: 156–159, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 31
    • 0024522034 scopus 로고
    • Cellular characterization of a new irreversible inhibitor of 5-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of LI210 cells
    • Kramer, D. L., Khomutov, R. M., Bukin, Y. V., Khomutov, A. R., and Porter, C. W. Cellular characterization of a new irreversible inhibitor of 5-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of LI210 cells. Biochem. J., 259: 325–331, 1989.
    • (1989) Biochem. J. , vol.259 , pp. 325-331
    • Kramer, D.L.1    Khomutov, R.M.2    Bukin, Y.V.3    Khomutov, A.R.4    Porter, C.W.5
  • 32
    • 0024366240 scopus 로고
    • Elucidation of the mechanism by which homocysteine potentiates the anti-Vaccinia virus effects of the 5-adenosylhomocysteine hydrolase inhibitor 9-(fraji5–2′, fraji5–3′-dihydroxycyclopent-4′-enyl)adenine
    • Hasobe, M., McKee, J. G., Ishii, H., Cools, M., Borchardt, R. T., and DeClercq, E. Elucidation of the mechanism by which homocysteine potentiates the anti-Vaccinia virus effects of the 5-adenosylhomocysteine hydrolase inhibitor 9-(fraji5–2′, fraji5–3′-dihydroxycyclopent-4′-enyl)adenine. Mol. Pharmacol., 36: 490–496, 1989.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 490-496
    • Hasobe, M.1    McKee, J.G.2    Ishii, H.3    Cools, M.4    Borchardt, R.T.5    DeClercq, E.6
  • 33
    • 0019203637 scopus 로고
    • Evidence that the inhibitory effect of adeonsine, but not cordycepin, on the methylation of nuclear RNA is mediated by 5-adenosylhomocysteine hydrolase
    • Glazer, R. I., and Hartman, K. D. Evidence that the inhibitory effect of adeonsine, but not cordycepin, on the methylation of nuclear RNA is mediated by 5-adenosylhomocysteine hydrolase. Mol. Pharmacol., 18: 483–490, 1980.
    • (1980) Mol. Pharmacol. , vol.18 , pp. 483-490
    • Glazer, R.I.1    Hartman, K.D.2
  • 35
    • 0021914533 scopus 로고
    • Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells
    • Iizasa, T., and Carson, D. A. Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells. Biochim. Biophys. Acta, 844: 280–287, 1985.
    • (1985) Biochim. Biophys. Acta , vol.844 , pp. 280-287
    • Iizasa, T.1    Carson, D.A.2
  • 36
    • 0017717986 scopus 로고
    • Role of 5-adenosylhomocysteine in adenosine mediated toxicity in cultured mouse T-lymphoma cells
    • Kredich, N. M., and Martin, D. W., Jr. Role of 5-adenosylhomocysteine in adenosine mediated toxicity in cultured mouse T-lymphoma cells. Cell, 12: 931–938, 1977.
    • (1977) Cell , vol.12 , pp. 931-938
    • Kredich, N.M.1    Martin, D.W.2
  • 37
    • 0024371786 scopus 로고
    • Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at 5-adenosylhomocysteine hydrolase
    • DeClercq, E., Cools, M., Balzarini, J., and DeClercq, M. Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at 5-adenosylhomocysteine hydrolase. Biochem. Pharmacol., 38: 1771–1778, 1989.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1771-1778
    • DeClercq, E.1    Cools, M.2    Balzarini, J.3    DeClercq, M.4
  • 39
    • 0021926377 scopus 로고
    • Reversibility of progression of the transformed phenotype in Ad5-transformed rat embryo cells
    • Babiss, L. E., Zimmer, S. G., and Fisher, P. B. Reversibility of progression of the transformed phenotype in Ad5-transformed rat embryo cells. Science (Wash. DC), 288: 1099–1101, 1985.
    • (1985) Science (Wash. DC) , vol.288 , pp. 1099-1101
    • Babiss, L.E.1    Zimmer, S.G.2    Fisher, P.B.3
  • 41
    • 0022971594 scopus 로고
    • DNA methyltransferase levels in tumor-igenic and nontumorigenic cells in culture
    • Kautiainen, T. L., and Jones, P. A. DNA methyltransferase levels in tumor-igenic and nontumorigenic cells in culture. J. Biol. Chem., 261: 1594–1598, 1986.
    • (1986) J. Biol. Chem. , vol.261 , pp. 1594-1598
    • Kautiainen, T.L.1    Jones, P.A.2


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