메뉴 건너뛰기




Volumn 8, Issue 6, 1990, Pages 567-581

Free radicals and anticancer drug resistance: Oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors

Author keywords

Antioxidant enzymes; Glutathione peroxidase; Multi drug resistance; Oxyradicals; Quinone containing anticancer drugs; Resistance; Tumor cells

Indexed keywords

DOXORUBICIN; FREE RADICAL; MITOMYCIN C;

EID: 0025309794     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(90)90155-C     Document Type: Article
Times cited : (180)

References (93)
  • 1
  • 4
    • 84918635097 scopus 로고    scopus 로고
    • Myers, C. E.; Cowan, K. H.; Sinha, B. K.; Chabner, B. The phenomenon of pleotropic drug resistance, In V. T. DeVita; S. Hellman; S. A. Rosenberg, eds., Important advances in oncology 1987. Philadelphia; Lippincott Co.; pp. 27–38.
  • 5
  • 8
    • 0022352607 scopus 로고
    • Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA
    • (1985) Cancer Res. , vol.45 , pp. 4091-4096
    • Harker1    Sikic2
  • 10
    • 0024353128 scopus 로고
    • Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression
    • (1989) Cancer Res. , vol.49 , pp. 4542-4549
    • Harker1    Slade2    Dalton3    Meltzer4    Trent5
  • 11
  • 16
    • 0018841542 scopus 로고
    • Binding specificity of chemically and enzymatically activated anthracyclines anticancer agents to nucleic acids
    • (1980) Chem Biol. Interact. , vol.30 , pp. 67-77
    • Sinha1
  • 17
    • 0019518327 scopus 로고
    • Role of one-electron and two-electron reduction products of adriamycin and daunomycin in DNA binding
    • (1981) Biochem. Pharmac. , vol.30 , pp. 2626-2629
    • Sinha1    Gregory2
  • 21
    • 0018194637 scopus 로고
    • A general mechanism for microsomal activation of quinone anticancer agents to free radicals
    • (1978) Cancer Res. , vol.38 , pp. 1745-1750
    • Bachur1    Gordon2    Gee3
  • 27
    • 0020036939 scopus 로고
    • Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects
    • (1982) Biochem. Pharmac. , vol.31 , pp. 575-581
    • Lown1    Chen2    Plambeck3    Acton4
  • 28
    • 0001213485 scopus 로고
    • Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by the anticancer quinones
    • 2nd ed.
    • (1986) Proc. Natl. Acad. Sci. (USA) , vol.83 , pp. 4514-4518
    • Doroshow1
  • 30
    • 0019457695 scopus 로고
    • Reduction of adriamycin to a semiquinone free radical by NADPH-cytochrome P-450 reductase produces DNA cleavage in a reaction mediated by molecular oxygen
    • (1981) J. Biol. Chem. , vol.256 , pp. 4747-4756
    • Berlin1    Haseltine2
  • 33
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities towards oxygenated and hypoxic tumor cells
    • (1981) Cancer Res. , vol.41 , pp. 73-81
    • Teicher1    Lazo2    Sartorelli3
  • 34
    • 0023182182 scopus 로고
    • Role of hypoxia in anticancer drug-induced cytotoxicity for Ehrlich cells
    • (1987) Cancer Res. , vol.47 , pp. 2407-2412
    • Gupta1    Costanzi2
  • 35
    • 0017746691 scopus 로고
    • Electron spin resonance studies on the mode of generation of free radicals of daunomycin, adriamycin, and carboquinone of free radicals of daunomycin, adriamycin, and carboquinone on NADPH-microsomal system
    • (1977) Gann , vol.68 , pp. 603-608
    • Sato1    Iwaizumi2    Handa3    Tamura4
  • 36
    • 0022532728 scopus 로고
    • Prevention of doxorubicin-induced killing of MCF-7 human breast cancer cells by oxygen radical scavengers and iron chelating agents
    • (1986) Biochem. Biophys. Res. Commun. , vol.135 , pp. 330-335
    • Doroshow1
  • 37
    • 0021846557 scopus 로고
    • Effects of vitamines on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells
    • (1985) J. Nutr. Sci. Vitaminol. , vol.31 , pp. 129-134
    • Okamoto1    Ogura2
  • 38
    • 0023688361 scopus 로고
    • The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells
    • (1988) Cancer Lett. , vol.41 , pp. 169-177
    • Cervantes1    Pinedo2    Lankelma3    Schuurhuis4
  • 39
    • 0021368025 scopus 로고
    • Oxygen radical detoxification enzymes in doxorubicin-sensitive and -resistant P388 murine leukemia cells
    • (1984) Cancer Res. , vol.44 , pp. 1976-1980
    • Ramu1    Cohen2    Glaubiger3
  • 45
    • 0023236652 scopus 로고
    • Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cell: implications for the mechanism of action
    • (1987) Biochemistry , vol.26 , pp. 3776-3781
    • Sinha1    Katki2    Batist3    Cowan4    Myers5
  • 46
    • 0024352416 scopus 로고
    • Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance
    • (1989) Cancer Res. , vol.49 , pp. 3844-3848
    • Sinha1    Mimnaugh2    Rajagopalan3    Myers4
  • 48
    • 0024493715 scopus 로고
    • Differential oxygen radical susceptibility of adriamycin-sensitive and-resistant MCF-7 human breast tumor cells
    • (1989) Cancer Res. , vol.49 , pp. 8-15
    • Mimnaugh1    Dusre2    Atwell3    Myers4
  • 52
    • 0024496217 scopus 로고
    • Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells
    • (1989) Cancer Res. , vol.49 , pp. 511-515
    • Dusre1    Mimnaugh2    Myers3    Sinha4
  • 58
    • 0019478520 scopus 로고
    • Protective role of glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes
    • (1981) Biochem. Pharmac. , vol.30 , pp. 2299-2304
    • Babson1    Abel2    Reed3
  • 62
    • 0022387475 scopus 로고
    • Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation
    • (1985) Cancer Treat. Rep. , vol.69 , pp. 1293-1296
    • Russo1    Mitchell2
  • 64
    • 0023767544 scopus 로고
    • Role of glutathione redox cycle in acquired and de novo multidrug resistance
    • (Washington, DC)
    • (1988) Science , vol.241 , pp. 694-697
    • Kramer1    Zakher2    Kim3
  • 65
    • 0000622931 scopus 로고
    • Photoaffinity labeling of the multidrug resistance-related P-glycoprotein with photoactive analogs of verapaminl
    • 2nd ed.
    • (1988) Proc. Natl. Acad. Sci (USA) , vol.85 , pp. 7187-7191
    • Safa1
  • 69
    • 0023778730 scopus 로고
    • Effects of endogenous glutathione, superoxide dismutase, catalase, and glutathione peroxidase on adriamycin tolelarnce of Chinese hamster ovary cells
    • (1988) Cancer Res. , vol.48 , pp. 4493-4497
    • Keizer1    van Rijin2    Pinedo3    Joenje4
  • 72
    • 0024312142 scopus 로고
    • Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomease II inhibitors and cross-resistant to peroxides
    • (1989) Cancer Res. , vol.49 , pp. 4526-4530
    • Davies1    Davies2    Harris3    Hickson4
  • 75
    • 0020037373 scopus 로고
    • Copper- and Zinc- containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutthione peroxidase in normal and neoplastic human cell lines and normal human tissues
    • (1982) Cancer Res. , vol.42 , pp. 1955-1961
    • Marklund1    Westman2    Lundgren3    Roos4
  • 76
    • 0019126450 scopus 로고
    • The effects of adriamycin (doxorubicin HCl0 on human red blood cells
    • (1980) Hemoglobin , vol.4 , pp. 735-745
    • Shinohara1    Tanaka2
  • 78
    • 0017194398 scopus 로고
    • A relative deficiency of cytochrome P-450 and aryl hydrocarbon (benzo(a)pyrene) hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver
    • (1976) Cancer Res. , vol.36 , pp. 3888-3893
    • Cameron1    Sweeney2    Jones3    Lee4    Farber5
  • 79
    • 0021984064 scopus 로고
    • A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat
    • (1985) Cancer Res. , vol.45 , pp. 564-571
    • Roomi1    Ho2    Sarma3    Farber4
  • 81
    • 0023875771 scopus 로고
    • Glutathione S-transferases and hepatocarcinogenesis
    • (Gann)
    • (1988) Jpn J. Cancer Res. , vol.79 , pp. 556-572
    • Sato1
  • 82
    • 0023835739 scopus 로고
    • Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines
    • (1988) Cancer Res. , vol.48 , pp. 527-533
    • Shea1    Kelley2    Henner3
  • 86
    • 0022640856 scopus 로고
    • Circumbention of deficient activation in mitomycin C-resistant human colonic carcinoma cells by the mitomycin C analogue BMY 25282
    • (1986) Cancer Res , vol.46 , pp. 3456-3458
    • Chakarbarty1    Danel2    Long3    Wilson4    Brattain5
  • 88
    • 0019513165 scopus 로고
    • Evidence for the generation of free radicals from certain quinone antitumor antibiotics upon reductive activation in solution
    • (1981) Can J. Chem. , vol.59 , pp. 390-395
    • Lown1    Chen2
  • 89
    • 0022622807 scopus 로고
    • Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics
    • (1986) Cancer Res. , vol.46 , pp. 3528-3532
    • Pritsos1    Sartorelli2
  • 91
  • 92
    • 0020665442 scopus 로고
    • Cytocidal action of the quinone group and its relationship to antitumor activity
    • (1983) Cancer Res. , vol.43 , pp. 481-484
    • Begleiter1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.