Synthesis, Phencyclidine-like Pharmacology, and Antiischemic Potential of Meta-Substituted 1-(1-Phenylcyclohexyl)-1,2,3,6-tetrahydropyridines

Journal of Medicinal Chemistry

Volumn 33, Issue 8, 1990, Pages 2211-2215

  Thurkauf, Andrew ^a,d   de Costa, Brian ^a   Mattson, Mariena V ^a   Jacobson, A E ^a   France, Charles P ^a,b   Woods, James H ^a,b   Price, Madelon T ^a,c   Olney, John W ^a,c   Rice, Kenner C ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NEUROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 (1 PHENYLCYCLOHEXYL)PYRIDINE DERIVATIVE; DIZOCILPINE; PHENCYCLIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ISCHEMIA; MONKEY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; ANIMALS, NEWBORN; ANOXIA; BINDING SITES; BRAIN; CHEMISTRY; DISCRIMINATION (PSYCHOLOGY); ISCHEMIA; KETAMINE; MACACA MULATTA; MOLECULAR STRUCTURE; PHENCYCLIDINE; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025309052     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00170a027     Document Type: Article

References (20)

1. Me Donald, J. W.; Silverstein, F. S.; Cardona, D.; Uckele, J.; Chen, R.; Johnston, M. V. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Kamenka, J. M., Eds.; NPP Books: Ann Arbor, MI, 1988; pp 697–708.
2. Goldberg, M. P.; Visekus, V.; Choi, D. W. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Kamenka, J. M., Eds.; NPP Books: Ann Arbor, MI, 1988; pp 709–716.
3. Natale, J. E.; Schott, R. J.; D’Alecy, L. G. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Kamenka, J. M., Eds.; NPP Books: Ann Arbor. MI. 1988; pp 771–776.
4. Marcoux, F. W.; Goodrich, J. E.; Probert, A. W.; Dominick, M. A. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Kamenka, J. M., Eds.; NPP Books: Ann Arbor, MI, 1988; pp 735–736.
5. Church, J.; Zeman, S.; Lodge, D. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Kamenka, J. M., Eds.; NPP Books: Ann Arbor, MI, 1988; pp 747–756.
6. Iversen, L. L.; Woodruff, G. N.; Kemp, J. A.; Foster, A. C.; Gill, R.; Wong, E. H. F. In Sigma and Phencyclidine-Like Compounds as Molecular Probes in Biology; Domino, E. F., Ka-menka, J. M., Eds.; NPP Books: Ann Arbor, MI, 1988: pp 757–766.
7. Wong, E. H. F.; Kemp, J. A.; Priestley, T.; Knight, A. R.; Woodruff, G. N. Iversen, L. L. Proc. Natl. Acad. Sci. U.S.A. 1986, 83, 7104.
8. Gill, R.; Foster, A. C.; Iversen, L. L.; Woodruff, G. N. J. Cereb. Blood Flow Metab. 1987, 7, S153.
9. Gill, R. A.; Foster, A. C.; Woodruff, G. N. J. Neurosci. 1987, 7, 3343.
10. McDonald, J. W.; Silverstein, F. S.; Johnston, M. V. Eur. J. Pharmacol. 1987. 140. 359.
11. Olney, J. W.; Ikonomidou, C.; Mosinger, J. L.; Frierdich, G. J. Neurosci. 1989, 9, 1701.
12. Sauer, D.; Nuglisch, J.; Rossberg, C.; Mennel, H.; Beck, T.; Bielenberg, G. W.; Krieglstein J. Neurosci. Lett. 1988, 91, 327.
13. Thurkauf, A.; Hillery, P.; Mattson, M.; Jacobson, A. E.; Rice, K. C. J. Med. Chem. 1988, 31, 1625.
14. McQuinn, R. L.; Cone, E. J.; Shannon, H. E.; Su, T. J. Med. Chem. 1981, 24, 1429.
15. Kamenka, J. M.; Chiche, B.; Goudal, R.; Geneste, P.; Vignon, J.;Vincent, J. P.: Lazdunski, M. J. Med. Chem. 1982, 25, 431.
16. Cone, E. J.; McQuinn, R. L.; Shannon, H. E. J. Pharmacol, Exp. Ther. 1984, 228, 147.
17. Maddox, V. H.; Godefroi, E. F.; Parcell, R. F. J. Med. Chem. 1965, 8, 230.
18. Jacobson, A. E.; Harrison, E. A., Jr.; Mattson, M. V.; Rafferty, M. G.; Rice, K. C.; Woods, J. H.; Winger, G.; Solomon, R. E.; Lessor, R. A.; Silverton, J. V. J. Pharmacol. Exp. Ther. 1987, 243, 110.
19. Cheng, Y. C.; Prusoff, W. H. Biochem Pharmacol. 1973, 22, 3099.
20. Ikonomidou, C.; Price, M. T.; Mosinger, J. L.; Frierdich, G.; Labruyere, J.; Shahid Salles, K.; Olney, J. W. J. Neurosci. 1989, 9, 1693.