In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.

British Journal of Clinical Pharmacology

Volumn 30, Issue 2, 1990, Pages 287-291

  Helsby, NA ^a   Ward, SA ^a   Howells, RE ^a   Breckenridge, AM ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROGUANIL; CYTOCHROME P450; MEPHENYTOIN; PROGUANIL; SPARTEINE; TOLBUTAMIDE;

ARTICLE; DRUG METABOLISM; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; LIVER MICROSOME; PRIORITY JOURNAL;

ANTIMALARIALS; BIOTRANSFORMATION; CHLOROGUANIDE; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; IN VITRO; MEPHENYTOIN; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; SPARTEINE; SUPPORT, NON-U.S. GOV'T; TOLBUTAMIDE;

EID: 0025307263     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1990.tb03777.x     Document Type: Article

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