4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A Novel Class of Potent Adenosine Receptor Antagonists and Potential Rapid-Onset Antidepressants

Journal of Medicinal Chemistry

Volumn 33, Issue 8, 1990, Pages 2240-2254

  Sarges, Reinhard ^a   Howard, Harry R ^a   Browne, Ronald G ^a   Lebel, Lorraine A ^a   Seymour, Patricia A ^a   Koe, B Kenneth ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3 HYDROXYPHENYL) 5H THIAZOLO[2,3 B]QUINAZOLINE; 4 AMINO 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE DERIVATIVE; 4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 8 CHLORO 4 CYCLOHEXYLAMINO 1 TRIFLUOROMETHYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR; AMPHETAMINE; CAFFEINE; CP 68247; CYCLIC AMP; CYCLOHEXYLADENOSINE; IMIPRAMINE; ISOBUTYLMETHYLXANTHINE; RADIOISOTOPE; ROLIPRAM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; DEPRESSION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RAT; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANIMAL; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CAFFEINE; CATS; CELL MEMBRANE; CEREBRAL CORTEX; CHEMISTRY; COMPARATIVE STUDY; CORPUS STRIATUM; MALE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; QUINOXALINES; RATS; RECEPTORS, PURINERGIC; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 0025306964     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00170a031     Document Type: Article

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