Novel Piperidine Derivatives. Synthesis and Anti-Acetylcholinesterase Activity of 1-Benzy1-4-[2-(N-benzoylamino)ethy1]piperidine Derivatives

Journal of Medicinal Chemistry

Volumn 33, Issue 7, 1990, Pages 1880-1887

  Sugimoto, Hachiro ^a   Tsuchiya, Yutaka ^a   Sugumi, Hiroyuki ^a   Higurashi, Kunizo ^a   Karibe, Norio ^a   Iimura, Yoichi ^a   Sasaki, Atsushi ^a   Kawakami, Yoshivuki ^a   Nakamura, Takaharu ^a   Araki, Shin ^a   Yamanishi, Yoshiharu ^a   Yamatsu, Kiyomi ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; N [2 (1 BENZYL 4 PIPERIDYL)ETHYL] N METHYL 4 BENZYLSULFONYLBENZAMIDE; N [2 (1 BENZYL 4 PIPERIDYL)ETHYL]BENZAMIDE DERIVATIVE; PHYSOSTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE BRAIN LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; DEMENTIA; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMAL; BENZYL COMPOUNDS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COMPARATIVE STUDY; INDICATORS AND REAGENTS; KINETICS; MALE; MOLECULAR STRUCTURE; PHYSOSTIGMINE; PIPERIDINES; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 0025297210     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00169a008     Document Type: Article

References (16)

1. Davies, P.; Maloney, A. J. Lancet 1976, 2, 1403.
2. Richter, J. A.; Perry, K. E.; Tomlinson, B. E. Life Sci. 1980, 26, 1683.
3. Perry, K. E.; Tomlinson, B. E.; Blessed, G.; Bergman, K.; Gibson, P. H.; Perry, R. H. Br. Med. J. 1979, 2, 1457.
4. Drachman, D. A.; Leavitt, J. B. Arch. Neurol. 1974, 30, 113.
5. Davis, K. L.; Mohs, R. C.; Timklenberg, J. R. N. Engl. J. Med. 1979, 301, 946.
6. Summers, W. K.; Majovski, L. V.; Marsh, G. M.; Aachiki, K.; Kling, A. N. Engl. J. Med. 1986, 315, 1241.
7. Sugimoto, H.; Tsuchiya, Y.; Sugumi, H.; Higurashi, K.; Karibe, N.; Kawakami, Y.; Araki, S.; Nakamura, T. J Pharm. Sci. 1987, 76, S 173.
8. Ellman, G. L.; Courtney, D.; Andres, V., Jr.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88.
9. Groff, W. A.; Ellin, R. I.; Skalsky, R. L. J. Pharm. Sci. 1977, 66 (3), 389.
10. Patocka, J.; Bajgor, J.; Bielavsky, J.; Fusek, J. Coll. Chech. Chem. Commun. 1976, 41, 816.
11. Tonkopil, V. D.; Ardabeva, T. V. Bill. Eksp. Biol. Med. 1978, 86, 441.
12. Main, A. R. In Essays in Toxicology; ed. Wayland and Hagen, Eds.; Academic Press: New York, 1973; Vol. 4, pp 59–105.
13. Vowinkel, E. Synthesis 1974, 6, 430.
14. Pettit, L. D.; Sherrington, C. J. Chem. Soc. A 1968, 3078.
15. Mathey, F.; Savignac, Ph. Tetrahedron 1978, 34, 649.
16. Asano, M.; Miyauchi, T.; Kato, T.; Fujimori, K.; Yamamoto, K. J. Liq. Chromatog. 1986, 9 (1), 199.