A80915, a new antibiotic complex produced by streptomyces aculeolatus: Discovery, taxonomy, fermentation, isolation, characterization, and antibacterial evaluation

The Journal of Antibiotics

Volumn 43, Issue 6, 1990, Pages 623-633

  Fukuda, D S ^a   Mynderse, J S ^a   Baker, P J ^a   Berry, D M ^a   Boeck, L D ^a   Yao, R C ^a   Mertz, F P ^a   Nakatsukasa, W M ^a   Mabe, J ^a   Ott, J ^a   Counter, F T ^a   Ensminger, P W ^a   Allen, N E ^a   Alborn, W E ^a   Hobbs, J N ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 80915; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; DNA SYNTHESIS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MANUFACTURE; DRUG MECHANISM; DRUG SCREENING; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA SYNTHESIS; STREPTOMYCES ACULEOLATUS; SUBCUTANEOUS DRUG ADMINISTRATION; TAXONOMY;

ANIMAL; ANTIBIOTICS; BACTERIA; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, BACTERIAL; FERMENTATION; MICE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; NAPHTHOQUINONES; RNA, BACTERIAL; SOIL MICROBIOLOGY; STAPHYLOCOCCAL INFECTIONS; STREPTOCOCCAL INFECTIONS; STREPTOMYCES;

EID: 0025292604     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.43.623     Document Type: Article

References (11)

1. Shiomi, K.; H. Iinuma, M. Hamada, H. Naganawa, M. Manabe, C. Matsuki, T. Takeuchi & H. Umezawa: Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity. J. Antibiotics 39: 487∼493, 1986.
2. Shiomi, K.; H. Nakamura, H. Iinuma, H. Naganawa, K. Isshiki, T. Takeuchi, H. Umezawa & Y. Iitaka: Structures of new antibiotics napyradiomycins. J. Antibiotics 39: 494∼501, 1986.
3. Shiomi, K.; H. Nakamura, H, Iinuma, H. Naganawa, T. Takeuchi, H. Umezawa & Y. Iitaka: New antibiotic napyradiomycins A2 and B4 and stereochemistry of napyradiomycins. J. Antibiotics 40: 1213∼1219, 1987.
4. Shiomi, K.; H. Iinuma, H. Naganawa, K. Isshiki, T. Takeuchi & H. Umezawa: Biosynthesis of napyradiomycins. J. Antibiotics 40: 1740∼1745, 1987.
5. Shomura, T.; S. Gomi, M. Ito, J. Yoshida, E. Tanaka, S. Amano, H. Watabe, S. Ohuchi, J. Itoh, M. Sezaki, H. Takebe & K. Uotani: Studies on new antibiotics SF2415. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J. Antibiotics 40: 732∼739, 1987.
6. Gomi, S.; S. Ohuchi, T. Sasaki, J. Itoh & M. Sezaki: Studies on new antibiotics SF2415. II. The structural elucidation. J. Antibiotics 40: 740∼749, 1987.
7. Keller-Juslén, C.; H. D. King, M. Kuhn, H.-R. Loosli, W. Pache, T. J. Petcher, H. P. Weber & A. von Wartburg: Tetronomycin, a novel polyether of unusual structure. J. Antibiotics 35: 142∼150, 1982.
8. Reed, L. J. & H. Muench: A simple method for estimating fifty percent endpoints. Am. J. Hygiene 27: 493∼497, 1938.
9. Allen, N. E.; J. N. Hobbs, Jr. & W. E. Alborn, Jr.: Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032. Antimicrob. Agents Chemother. 31: 1093∼1099, 1987.
10. Lechevalier, M. P. & H. Lechevalier: Chemical composition as a criterion in the classification of aerobic actinomycetes. Int. J. Syst. Bacteriol. 20: 435∼443, 1970.
11. Olenick, J. G. & F. E. Hahn: Bactericidal action of a 2-hydroxy-3-alkyl-1,4-naphthoquinone: Blockade of metabolite permeation across the membrane. Ann. N. Y. Acad. Sci. 235: 542∼552, 1974.