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Volumn 85, Issue 6, 1990, Pages 1844-1852

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: A novel mechanism for insulin resistance

Author keywords

Free fatty acids; Glucose uptake; Lactate

Indexed keywords

GLUCOSE; INSULIN;

EID: 0025292440     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI114644     Document Type: Article
Times cited : (933)

References (52)
  • 1
    • 0019365482 scopus 로고
    • Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes
    • Olefsky, J. M., and O. G. Kolterman. 1981. Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes. Am. J. Med. 70:151-168.
    • (1981) Am. J. Med. , vol.70 , pp. 151-168
    • Olefsky, J.M.1    Kolterman, O.G.2
  • 2
    • 0018896297 scopus 로고
    • Mechanisms of insulin resistance in human obesity. Evidence for receptor and postreceptor defects
    • Kolterman, O. G., J. Insel, M. Saekow, and J. M. Olefsky. 1980. Mechanisms of insulin resistance in human obesity. Evidence for receptor and postreceptor defects. J. Clin. Invest. 65:1272-1284.
    • (1980) J. Clin. Invest. , vol.65 , pp. 1272-1284
    • Kolterman, O.G.1    Insel, J.2    Saekow, M.3    Olefsky, J.M.4
  • 3
    • 73649168830 scopus 로고
    • Forearm metabolism in obesity and its response to intraarterial insulin
    • Rabinowitz, D., and K. L. Zierler. 1962. Forearm metabolism in obesity and its response to intraarterial insulin. J. Clin. Invest. 41:2173-2181.
    • (1962) J. Clin. Invest. , vol.41 , pp. 2173-2181
    • Rabinowitz, D.1    Zierler, K.L.2
  • 5
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catherization
    • DeFronzo, R. A., E. Jacot, E. Jequier, E. Maeder, J. Wahren, and J. P. Felber. 1981. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catherization. Diabetes. 30:1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 6
    • 0021733738 scopus 로고
    • Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography
    • Evans, D. J., R. Murray, and A. H. Kissebah. 1984. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding. Effects of obesity and body fat topography. J. Clin. Invest. 74:1515-1525.
    • (1984) J. Clin. Invest. , vol.74 , pp. 1515-1525
    • Evans, D.J.1    Murray, R.2    Kissebah, A.H.3
  • 7
    • 0000497038 scopus 로고
    • Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady state
    • Zierler, K. L. 1961. Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non-steady state. J. Clin. Invest. 40:2111-2125.
    • (1961) J. Clin. Invest. , vol.40 , pp. 2111-2125
    • Zierler, K.L.1
  • 8
    • 0023683874 scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • Dohm, G. L., E. B. Tapscott, W. J. Pories, D. J. Dabbs, E. G. Flickinger, D. Meelheim, T. Fushiki, S. M. Atkinson, C. W. Elton, and J. F. Caro. 1988. An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82:486-494.
    • (1988) J. Clin. Invest. , vol.82 , pp. 486-494
    • Dohm, G.L.1    Tapscott, E.B.2    Pories, W.J.3    Dabbs, D.J.4    Flickinger, E.G.5    Meelheim, D.6    Fushiki, T.7    Atkinson, S.M.8    Elton, C.W.9    Caro, J.F.10
  • 10
    • 0019969369 scopus 로고
    • Insulin infusion in conscious dogs. Effects on systemic and coronary hemodynamics, regional blood flows, and plasma catecholamines
    • Liang, C. S., J. U. Doherty, R. Faillace, K. Maekawa, S. Arnold, H. Gavras, and W. B. Hood, Jr. 1982. Insulin infusion in conscious dogs. Effects on systemic and coronary hemodynamics, regional blood flows, and plasma catecholamines. J. Clin. Invest. 69:1321-1336.
    • (1982) J. Clin. Invest. , vol.69 , pp. 1321-1336
    • Liang, C.S.1    Doherty, J.U.2    Faillace, R.3    Maekawa, K.4    Arnold, S.5    Gavras, H.6    Hood Jr., W.B.7
  • 11
    • 0023470506 scopus 로고
    • The effects of insulin-induced hypoglycemia on cardiovascular function in normal man: Studies using radionuclide ventriculography
    • Fisher, B. M., G. Gillen, H. J. Dargie, G. C. Inglis, and B. M. Frier. 1987. The effects of insulin-induced hypoglycemia on cardiovascular function in normal man: studies using radionuclide ventriculography. Diabetologia 30:841-845.
    • (1987) Diabetologia , vol.30 , pp. 841-845
    • Fisher, B.M.1    Gillen, G.2    Dargie, H.J.3    Inglis, G.C.4    Frier, B.M.5
  • 12
    • 0023196951 scopus 로고
    • Effects of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man
    • Gelfand, R. A., and E. J. Barrett. 1987. Effects of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. J. Clin. Invest. 80:1-6.
    • (1987) J. Clin. Invest. , vol.80 , pp. 1-6
    • Gelfand, R.A.1    Barrett, E.J.2
  • 13
    • 0022367327 scopus 로고
    • Beta adrenergic-mediated vasodilator response to insulin in the human forearm
    • Creager, M., L. Chang-Seng, and J. D. Coffman. 1985. Beta adrenergic-mediated vasodilator response to insulin in the human forearm. J. Pharmacol. Exp. Ther. 235:709-714.
    • (1985) J. Pharmacol. Exp. Ther. , vol.235 , pp. 709-714
    • Creager, M.1    Chang-Seng, L.2    Coffman, J.D.3
  • 14
    • 0024597695 scopus 로고
    • Effect of exercise on insulin action in human skeletal muscle
    • Richter, E. A., K. J. Mikines, H. Galbo, and B. Kiens. 1989. Effect of exercise on insulin action in human skeletal muscle. J. Appl. Physiol. 66:876-885.
    • (1989) J. Appl. Physiol. , vol.66 , pp. 876-885
    • Richter, E.A.1    Mikines, K.J.2    Galbo, H.3    Kiens, B.4
  • 15
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catherization
    • DeFronzo, R. A., E. Jacot, E. Jequier, E. Maeder, J. Wahren, and J. P. Felber. 1981. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catherization. Diabetes. 30:1000-1007.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6
  • 16
    • 0020684724 scopus 로고
    • Regulation of splanchnic and peripheral glucose up-take by insulin and hyperglycemia in man
    • DeFronzo, R. A., E. Ferrannini, R. Hendler, P. Felig, and J. Wahren. 1983. Regulation of splanchnic and peripheral glucose up-take by insulin and hyperglycemia in man. Diabetes 32:35-45.
    • (1983) Diabetes , vol.32 , pp. 35-45
    • DeFronzo, R.A.1    Ferrannini, E.2    Hendler, R.3    Felig, P.4    Wahren, J.5
  • 17
    • 0022537566 scopus 로고
    • Impact of glucose ingestion on hepatic and peripheral glucose metabolism in man: An analysis based on simultaneous use of the forearm and double isotope techniques
    • Jackson, R. A., R. D. Roshania, M. I. Hawa, B. M. Sim, and L. DiSilvio. 1986. Impact of glucose ingestion on hepatic and peripheral glucose metabolism in man: an analysis based on simultaneous use of the forearm and double isotope techniques. J. Clin. Endocrinol. & Metab. 63:541-549.
    • (1986) J. Clin. Endocrinol. & Metab. , vol.63 , pp. 541-549
    • Jackson, R.A.1    Roshania, R.D.2    Hawa, M.I.3    Sim, B.M.4    DiSilvio, L.5
  • 18
    • 0022468683 scopus 로고
    • The influence of graded hyperglycemia with and without physiological hyperinsulinemia on forearm glucose uptake and other metabolic responses in man
    • Jackson, R. A., J. B. Hamling, P. M. Blix, B. M. Sim, M. I. Hawa, J. B. Jaspan, J. Belin, and J. D. N. Nabarro. 1986. The influence of graded hyperglycemia with and without physiological hyperinsulinemia on forearm glucose uptake and other metabolic responses in man. J. Clin. Endocrinol. & Metab. 63:594-604.
    • (1986) J. Clin. Endocrinol. & Metab. , vol.63 , pp. 594-604
    • Jackson, R.A.1    Hamling, J.B.2    Blix, P.M.3    Sim, B.M.4    Hawa, M.I.5    Jaspan, J.B.6    Belin, J.7    Nabarro, J.D.N.8
  • 19
    • 0023278013 scopus 로고
    • Kinetics of glucose disposal in whole body and across the forearm in man
    • Yki-Jarvinen, H., A. A. Young, C. Lamkin, and J. E. Foley. 1987. Kinetics of glucose disposal in whole body and across the forearm in man. J. Clin. Invest. 79:1713-1719.
    • (1987) J. Clin. Invest. , vol.79 , pp. 1713-1719
    • Yki-Jarvinen, H.1    Young, A.A.2    Lamkin, C.3    Foley, J.E.4
  • 20
    • 0018602014 scopus 로고
    • Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
    • National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
    • (1979) Diabetes , vol.28 , pp. 1039-1057
  • 21
    • 0018520840 scopus 로고
    • Glucose clamp technique. A method for quantifying insulin secretion and resistance
    • DeFronzo, R. A., J. D. Tobin, and R. Andres. 1979. Glucose clamp technique. A method for quantifying insulin secretion and resistance. Am. J. Physiol. 273:E214-E223.
    • (1979) Am. J. Physiol. , vol.273
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 22
    • 0022500793 scopus 로고
    • In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects
    • Prager, R., P. Wallace, and J. M. Olefsky. 1986. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J. Clin. Invest. 78:472-481.
    • (1986) J. Clin. Invest. , vol.78 , pp. 472-481
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 23
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin and insulin-mediated glucose uptake in humans
    • Baron, A. D., G. Brechtel, P. Wallace, and S. V. Edelman. 1988. Rates and tissue sites of non-insulin and insulin-mediated glucose uptake in humans. Am. J. Physiol. 255:E769-E774.
    • (1988) Am. J. Physiol. , vol.255
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 24
    • 0344278715 scopus 로고
    • Measurement of blood flow in the femoral artery in man at rest and during exercise by local thermodilution
    • Ganz, V., A. Fronek, J. Linhart, and I. Prerovsky. 1964. Measurement of blood flow in the femoral artery in man at rest and during exercise by local thermodilution. Circulation. 30:86-89.
    • (1964) Circulation , vol.30 , pp. 86-89
    • Ganz, V.1    Fronek, A.2    Linhart, J.3    Prerovsky, I.4
  • 25
    • 0001340161 scopus 로고
    • Importance of hematocrit in interpretation of blood sugar
    • Dillon, R. S. 1965. Importance of hematocrit in interpretation of blood sugar. Diabetes. 14:672-674.
    • (1965) Diabetes , vol.14 , pp. 672-674
    • Dillon, R.S.1
  • 27
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemiceuglycemic glucose clamps: Comparison of unlabelled and labelled exogenous glucose infusates
    • Finegood, D. T., R. N. Bergman, and M. Vranic. 1987. Estimation of endogenous glucose production during hyperinsulinemiceuglycemic glucose clamps: comparison of unlabelled and labelled exogenous glucose infusates. Diabetes. 36:914-924.
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 28
    • 0022361971 scopus 로고
    • Assessment of insulin sensitivity in vivo
    • Bergman, R., D. T. Finegood, and M. Ader. 1985. Assessment of insulin sensitivity in vivo. Endocr. Res. 6:45-86.
    • (1985) Endocr. Res. , vol.6 , pp. 45-86
    • Bergman, R.1    Finegood, D.T.2    Ader, M.3
  • 29
    • 0015146643 scopus 로고
    • Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmunoassay
    • Desbuquois, B., and G. D. Aurbach. 1971. Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmunoassay. J. Clin. Endocrinol. & Metab. 33:732-738.
    • (1971) J. Clin. Endocrinol. & Metab. , vol.33 , pp. 732-738
    • Desbuquois, B.1    Aurbach, G.D.2
  • 30
    • 0002364639 scopus 로고
    • Colorimetric determination of free fatty acids in biological fluids
    • Itaya, K., and M. Vi. 1965. Colorimetric determination of free fatty acids in biological fluids. J. Lipid Res. 6:16-20.
    • (1965) J. Lipid Res. , vol.6 , pp. 16-20
    • Itaya, K.1    Vi, M.2
  • 32
    • 0018001339 scopus 로고
    • Simultaneous analysis of families of sigmoideal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
    • DeLean, A., P. J. Munson, and D. Rodbard. 1978. Simultaneous analysis of families of sigmoideal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 235:E97-E102.
    • (1978) Am. J. Physiol. , vol.235
    • DeLean, A.1    Munson, P.J.2    Rodbard, D.3
  • 33
    • 0024240443 scopus 로고
    • Cellular mechanisms of insulin resistance in non-insulin-dependent (Type II) diabetes
    • Olefsky, J. M., W. T. Garvey, R. R. Henry, S. Matthaei, and G. R. Freidenberg. 1988. Cellular mechanisms of insulin resistance in non-insulin-dependent (Type II) diabetes. Am. J. Med. 85(Suppl. 5A):86-105.
    • (1988) Am. J. Med. , vol.85 , Issue.SUPPL. 5A , pp. 86-105
    • Olefsky, J.M.1    Garvey, W.T.2    Henry, R.R.3    Matthaei, S.4    Freidenberg, G.R.5
  • 35
    • 0024026298 scopus 로고
    • The triumvirate: Beta-cell, muscle, liver: a collusion responsible for NIDDM
    • DeFronzo, R. A. 1988. The triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 36
    • 0019518496 scopus 로고
    • Mechanisms of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity
    • Ciaraldi, T. P., O. G. Kolterman, and J. M. Olefsky. 1981. Mechanisms of the postreceptor defect in insulin action in human obesity. Decrease in glucose transport system activity. J. Clin. Invest. 68:875-880.
    • (1981) J. Clin. Invest. , vol.68 , pp. 875-880
    • Ciaraldi, T.P.1    Kolterman, O.G.2    Olefsky, J.M.3
  • 37
    • 0023019103 scopus 로고
    • Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size
    • Karnieli, E., A. Barzilai, R. Rafaeloff, and M. Armoni. 1986. Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size. J. Clin. Invest. 78:1051-1055.
    • (1986) J. Clin. Invest. , vol.78 , pp. 1051-1055
    • Karnieli, E.1    Barzilai, A.2    Rafaeloff, R.3    Armoni, M.4
  • 38
    • 0023893104 scopus 로고
    • Role of glucose transporters in the cellular insulin resistance of Type II non-insulin-dependent diabetes mellitus
    • Garvey, T. W., T. P. Huecksteadt, S. Matthaei, and J. M. Olefsky. 1988. Role of glucose transporters in the cellular insulin resistance of Type II non-insulin-dependent diabetes mellitus. J. Clin. Invest. 81:1528-1536.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1528-1536
    • Garvey, T.W.1    Huecksteadt, T.P.2    Matthaei, S.3    Olefsky, J.M.4
  • 40
    • 17744405359 scopus 로고
    • Dose-response characteristics for the effects of insulin on production and utilization of glucose in man
    • Rizza, R. A., J. L. Mandarino, and J. E. Gerich. 1981. Dose-response characteristics for the effects of insulin on production and utilization of glucose in man. Am. J. Physiol. 240:E630-639.
    • (1981) Am. J. Physiol. , vol.240
    • Rizza, R.A.1    Mandarino, J.L.2    Gerich, J.E.3
  • 41
    • 0019935341 scopus 로고
    • The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man
    • Thiebaud, D., E. Jacot, R. A. DeFronzo, E. Maeder, E. Jequier, and J.-P. Felber. 1982. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes. 31:957-963.
    • (1982) Diabetes , vol.31 , pp. 957-963
    • Thiebaud, D.1    Jacot, E.2    DeFronzo, R.A.3    Maeder, E.4    Jequier, E.5    Felber, J.-P.6
  • 42
    • 0023832956 scopus 로고
    • Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus
    • Campbell, P. J., L. J. Mandarino, and J. E. Gerich. 1988. Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. Metabolism. 37:15-21.
    • (1988) Metabolism , vol.37 , pp. 15-21
    • Campbell, P.J.1    Mandarino, L.J.2    Gerich, J.E.3
  • 43
    • 0019413380 scopus 로고
    • Enhanced glucose utilization during prolonged glucose clamp studies
    • Doberne, L., M. S. Greenfield, B. Schulz, and G. M. Reaven. 1981. Enhanced glucose utilization during prolonged glucose clamp studies. Diabetes. 30:829-835.
    • (1981) Diabetes , vol.30 , pp. 829-835
    • Doberne, L.1    Greenfield, M.S.2    Schulz, B.3    Reaven, G.M.4
  • 45
    • 0024423823 scopus 로고
    • Insulin transport across capillaries is rate-limiting step insulin action in dogs
    • Yang, Y. J., I. D. Hope, and R. N. Bergman. 1989. Insulin transport across capillaries is rate-limiting step insulin action in dogs. J. Clin. Invest. 84:1620-1628.
    • (1989) J. Clin. Invest. , vol.84 , pp. 1620-1628
    • Yang, Y.J.1    Hope, I.D.2    Bergman, R.N.3
  • 48
    • 0021804310 scopus 로고
    • Regulation of muscle blood flow
    • Hudlicka, O. 1985. Regulation of muscle blood flow. Clin. Physiol. 5:201-229.
    • (1985) Clin. Physiol. , vol.5 , pp. 201-229
    • Hudlicka, O.1
  • 49
    • 0022869705 scopus 로고
    • Autoregulation of blood flow
    • Johnson, P. C. 1986. Autoregulation of blood flow. Circ. Res. 59:483-495.
    • (1986) Circ. Res. , vol.59 , pp. 483-495
    • Johnson, P.C.1


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