Cyclic Hexapeptide Oxytocin Antagonists. Potency-, Selectivity-, and Solubility-Enhancing Modifications

Journal of Medicinal Chemistry

Volumn 33, Issue 7, 1990, Pages 1843-1845

  Freidinger, R M ^a   Williams, P D ^b   Tung, R D ^b   Bock, M G ^b   Pettibone, D J ^b   Clineschmidt, B V ^b   DiPardo, R M ^b   Erb, J M ^b   Garsky, V M ^b   Gould, N P ^b   Kaufman, M J ^b   Lundell, G F ^b   Perlow, D S ^b   Whitter, W L ^b   Veber, D F ^b  

^a Institute of Medicinal Chemistry   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; CYCLIC HEXAPEPTIDE; L 365209; OXYTOCIN; OXYTOCIN ANTAGONIST; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; KIDNEY; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; UTERUS;

AMINO ACID SEQUENCE; ANIMAL; ARGIPRESSIN; CELL MEMBRANE; COMPARATIVE STUDY; FEMALE; INDICATORS AND REAGENTS; KIDNEY; LIVER; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXYTOCIN; PEPTIDES, CYCLIC; RATS; RECEPTORS, ANGIOTENSIN; RECEPTORS, OXYTOCIN; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UTERUS;

EID: 0025291574     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00169a001     Document Type: Article

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