Brain targeting of anti-HIV nucleosides: Synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3′-azido-2′,3′-dideoxyuridine and 3′-azido-3′-deoxythymidine

Journal of Medicinal Chemistry

Volumn 33, Issue 8, 1990, Pages 2188-2192

  Chu, C K ^a   Bhadti, V S ^a   Doshi, K J ^a   Etse, J T ^a   Gallo, J M ^a   Boudinot, F D ^a   Schinazi, R F ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' AZIDO 2',3' DIDEOXY 5' O [(1,4 DIHYDRO 1 METHYL 3 PYRIDYL)CARBONYL]URIDINE; 3' AZIDO 2',3' DIDEOXYURIDINE; 3' AZIDO 2',3' DIDEOXYURIDINE DERIVATIVE; 3' AZIDO 3' DEOXY 5' O [(1,4 DIHYDRO 1 METHYL 3 PYRIDYL)CARBONYL]THYMIDINE; PRODRUG; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTIVIRAL AGENTS; BRAIN; CHEMISTRY; COMPARATIVE STUDY; DIHYDROPYRIDINES; HALF-LIFE; HIV; HUMAN; MICE; MOLECULAR STRUCTURE; PRODRUGS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; ZIDOVUDINE;

EID: 0025290649     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm00170a023     Document Type: Article

References (33)