Human Glutathione 5-Transferase Deficiency as a Marker of Susceptibility to Epoxide-induced Cytogenetic Damage

Cancer Research

Volumn 50, Issue 5, 1990, Pages 1585-1590

  Wiencke, John K ^a   Kelsey, Karl T ^b   Lamela, Rosito A ^a   Toscano, William A ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPOXIDE; GLUTATHIONE TRANSFERASE; ISOENZYME; STILBENE OXIDE;

ARTICLE; DIAGNOSIS; GENETIC DAMAGE; HUMAN; HUMAN CELL; METHODOLOGY; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

ADULT; AGED; CHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE TRANSFERASE; HUMAN; ISOENZYMES; LYMPHOCYTES; MALE; SISTER CHROMATID EXCHANGE; STILBENES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025275872     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Arias, I. M. and Jakoby, W. B. Glutathione: Metabolism and Function. New York: Raven Press, 1976.
2. Chasseaud, L. F. The role of glutathione and glutathione 5-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv. Cancer Res., 29:175–274, 1979.
3. Jakoby, W. B., and Habig, W. H. Glutathione transferases. In: Jakoby, W. B. (ed.), Enzymatic Basis of Detoxication, Vol. 2, pp. 63–94. New York: Academic Press, 1980.
4. Mannervik, B. The isoenzymes of glutathione transferase. Adv. Enzymol., 57:357–417, 1985.
5. Board, P. G. Biochemical genetics of glutathione 5-transferase in man. Am. J. Hum. Genet., 33: 36–43, 1981.
6. Silberstein, D. L., and Shows, T. B. Gene for glutathione 5-transferase-1 (GST1) is on human chromosome 11. Somat. Cell Genet., 8:667–675,1982.
7. Suzuki, T., and Board, P. Glutathione 5-transferase gene mapped to chromosome 11 is GST3 not GST1 (Letter to the Editor). Somat. Cell Mol. Genet., 70:319–320, 1984.
8. Laisney, V., Nguyen, V. C., Gross, M. S., and Frezal, J. Human genes for glutathione 5-transferases. Hum. Genet., 68:221–227, 1984.
9. Board, P. G., and Webb, G. C. Isolation of a cDNA clone and localization of human glutathione 5-transferase 2 genes to chromosome band 6pl2. Proc. Natl. Acad. Sci.USA, 84:2377–2381, 1987.
10. DeJong, J. L., Chang, C. M., Whang-Peng, J., Knutsen, T., and Tu, C. P. D. The human liver glutathione 5-transferase gene superfamily: expression and chromosome mapping of an Hb subunit cDNA. Nucleic Acids Res., 16: 8541–8554,1988.
11. Quamrul Islam, M., Platz, A., Szpirer, J., Szpirer, C., Levan, G., and Mannervik, B. Chromosomal localization of human glutathione transferase genes of classes alpha, mu and pi. Hum. Genet., 82:338–342, 1989.
12. Warholm, M., Guthenberg, C., Mannervik, B., von Bahr, C., and Glaumann, H. Identification of a new glutathione 5-transferase in human liver. Acta Chem. Scand (Series B), 34:607–610, 1980.
13. Warholm, M., Guthenberg, C., and Mannervik, B. Molecular and catalytic properties of glutathione transferase m from human liven an enzyme efficiently conjugating epoxides. Biochemistry, 22: 3610–3617, 1983.
14. Seidegard, J., Guthenberg, C., Pero, R. W., and Mannervik, B. The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase μ- Biochem. J., 246: 783–785,1987.
15. Seidegard, J., and Pero, R. W. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum. Genet., 69:66–68, 1985.
16. Seidegard, J., DePierre, J. W., and Pero, R. W. Hereditary interindividual differences in glutathione transferase towards trans-stilbene oxide in resting human mononuclear leukocytes are due to a particular isozyme(s). Carcinogenesis (Lond.), 6: 1211–1216, 1985.
17. Seidegard, J., Vorachek, W. R., Pero, R. W., and Pearson, W. R. Hereditary differences in the expression of the human glutathione transferase active on transs-stilbene oxide are due to a gene deletion. Proc. Natl. Acad. Sci.USA, 85:7293–7297,1988.
18. Seidegard, J., Pero, R. W., Miller, D. G., and Beattie, E. J. A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis (Lond.), 7: 751–753, 1986.
19. Paterson, M. C. Environmental carcinogenesis and imperfect repair of damaged DNA in Homo sapiens-, causal relation revealed by rare hereditary disorders. In: A. C. Griffin, and C. R. Shaw (Eds.), Carcinogens: Identification and Mechanisms of Action, pp. 251–276. New York: Raven Press, 1978.
20. Wolff, S. Sister chromatid exchange: the most sensitive mammalian system for determining the effects of mutagenic carcinogens. In: K. Berg (ed.), Genetic Damage in Man Caused by Environmental Agents, pp. 229–246. New York: Academic Press, 1979.
21. Perry, P., and Wolff, S. Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange. Nature (Lond.), 251: 156–158,1974.
22. Boyum, A. Separation of leukocytes from blood and bone marrow. Introduction. Scand. J. Clin. Lab. Invest., 21 (Suppl. 97): 77, 1968.
23. Peterson, G. L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem., 83:346–356, 1977.
24. Dixon, W. J. Analysis of variance and covariance. In: W. J. Dixon (ed.), BMDP Statistical Softward Manual, pp. 347–358. Berkeley, CA: University of California Press, 1985.
25. Daly, J. W., Jerina, D. M., and Witkop, B. Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds. Exper-ientia (Basel), 28:1129–1149,1972.
26. Sims, P., and Grover, P. L. Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. Adv. Cancer Res., 20:165–274, 1974.
27. Yang, S. K., Deutsch, J., and Gelboin, H. V. Benzo[a]pyrene metabolism: activation and detoxification. In: H. C. Gelboin and P. O. P. Tso (eds.), Polycyclic Hydrocarbons and Cancer, Vol. 1, pp. 205–231. New York: Academic Press, 1978.
28. Hernandez, O., and Bend, J. R. Metabolism of epoxides. In: W. B. Jakoby, J. R. Bend, and J. Caldwell (eds.), Metabolic Basis of Detoxification, pp. 207–228. New York: Academic Press, 1982.
29. Huberman, E., Aspiras, L., Heidelberger, C., Grover, P. L., and Sims, P. Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons. Proc. Natl. Acad. Sci. USA, 68:3195–3199, 1971.
30. Ames, B. N., Sims, P., and Grover, P. L. Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens. Science (Wash. D.C.), 176: 47–49, 1972.
31. Oesch, F. Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds. Xenobiotica, 3: 305–340, 1973.
32. Mannervik, B., and Daniel son, U. H. Glutathione transferases: structure and catalytic activity. Crit. Rev. Biochem., 23: 283–337, 1988.
33. Meijer, J., and DePierre, J. W. Cytosolic epoxide hydrolase. Chem. Biol. Interact., 64:207–249, 1988.
34. Robertson, I. G. C., Guthenberg, C., Mannervik, B., and Jernstrom, B. Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7β,8α-dihydroxy-9#x03B1;,10#x03B1;-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene. Cancer Res., 46: 2220–2224,1986.
35. Warholm, M., Guthenberg, C., Mannervik, B., and von Bahr, C. Purification of a new glutathione S-transferase (transferase μ) from human liver having high activity with benzo(a)pyrene-4,5-oxide. Biochim. Biophys. Res. Commun., 98:512–519, 1981.
36. Baggett, M. S., Morie, G. P., Simmons, M. W., and Lewis, J. S. Quantitative determination of semi volatile compounds in cigarette smoke. J. Chromatogr., 97: 79–82, 1974.
37. Tornqvist, M., Osterman-Golkar, S., Kautiainen, A., Jensen, S., Farmer, P. B., and Ehrenberg, L. Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin. Carcinogenesis (Lond.), 7: 1519–1521, 1986.
38. Glatt, H. R., and Oesch, F. Inactivation of electrophilic metabolites by glutathione transferases and limitation of the system due to subcellular localization. Arch. Toxicol., 39:87–96, 1977.
39. Boyer, T. D., Zakim, D., and Vessey, D. A. Do the soluble glutathione S-transferases have direct access to membrane-bound substrates? Biochem. Pharmacol., 32:29–35,1983.
40. Woolhouse, N. M., and Atu-Taylor, L. C. Influence of double genetic polymorphism on response to sulfamethazine. Clin. Pharmacol. Ther., 31: 377–383, 1982.
41. Mertes, I., Fleischmann, R., Glatt, H. R. and Oesch, F. Interindividual variations in the activities of cytosolic and microsomal epoxide hydrolase in human liver. Carcinogenesis (Lond.), 6: 219–223, 1985.
42. Seidegard, J., DePierre, J. W., and Pero, R. W. Measurement and characterization of membrane-bound and soluble epoxide hydrolase activities in resting mononuclear leukocytes from human blood. Cancer Res., 44: 3654–3660, 1984.
43. Guenthner, T. M. Selective inhibition and selective induction of multiple microsomal epoxide hydrolases. Biochem. Pharmacol., 35:839–845, 1986.
44. Gill, S. S., Ota, K., and Hammock, B. D. Radiometric assays for mammalian epoxide hydrolases and glutathione S-transferase. Anal. Biochem., 131:273–282, 1983.
45. Glatt, H., Friedberg, T., Grover, P. L., Sims, P., and Oesch, F. Inactivation of a diol-epoxide and a K-region epoxide with high efficiency by glutathione transferase X. Cancer Res., 43:5713–5717, 1983.
46. Oesch, F. Significance of various enzymes in the control of reactive metabolites. Arch. Toxicol., 60:174–178, 1987.
47. Batist, G., Tulpule, A., Sinha, B. K., Katki, A. G., Myers, C. E., and Cowan, K. H. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem., 261:15544–15549,1986.
48. Buller, A. L., Clapper, M. L., and Tew, K. D. Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines. Mol. Pharmacol., 31: 575–578,1987.
49. Mannervik, B., Castro, V. M., Danielson, U. H., Tahir, M. K., Hansson, J., and Ringborg, U. Expression of class pi glutathione transferase in human malignant melanoma cells. Carcinogenesis (Lond.), 8:1929–1932, 1987.
50. Shiratori, Y., Soma, Y., Maruyama, H., Sato, S., Takano, A., and Sato, K. Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesions. Cancer Res., 47:6806–6809, 1987.
51. Eimoto, H., Tsutsumi, M., Nakajima, A., Yamamoto, K., Takashima, Y., Maruyama, H., and Konishi, Y. Expression of the glutathione 5-transferase placental form in human lung carcinomas. Carcinogenesis (Lond.), 9:2325–2327, 1988.
52. Shea, T. C., Kelley, S. L., and Henner, W. D. Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines. Cancer Res., 48: 527–533, 1988.
53. Singh, S. V., Haque, A. K., Ahmad, H., Medh, R. D., and Awasthi, Y. C. Glutathione S-transferase isoenzymes in human lung tumors. Carcinogenesis (Lond.), 9:1681–1685, 1988.
54. Smith, M. T., Evans, C. G., Doane-Setzer, P., Castro, V. M., Tahir, M. K., and Mannervik, B. Denitrosation of l,3-bis(2-chloroethyl)-l-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. Cancer Res., 49:2621–2625,1989.