Insulin sensitivity in newly detected hypertensive patients: Influence of captopril and other antihypertensive agents on insulin sensitivity and related biological parameters

Journal of Cardiovascular Pharmacology

Volumn 15, Issue , 1990, Pages S46-S52

  Lithell, Hans O ^a   Pollare, Thomas ^a   Berne, Christian ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Glucose; Hypertension; Insulin; Insulin sensitivity; Lipid profile; Nonobese hypertensive patient

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATENOLOL; CAPTOPRIL; DILTIAZEM; GLUCOSE; HYDROCHLOROTHIAZIDE; METOPROLOL;

CONFERENCE PAPER; CORONARY ARTERY DISEASE; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPOPROTEIN BLOOD LEVEL; METABOLISM; PRIORITY JOURNAL; RISK FACTOR;

ANTIHYPERTENSIVE AGENTS; CAPTOPRIL; HUMAN; HYPERTENSION; INSULIN; INSULIN RESISTANCE;

EID: 0025275510     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/00005344-199000155-00007     Document Type: Article

References (22)

1. Kannel WB, Dawber TR, Friedman GD, et al. Risk factors in coronary heart disease: an evaluation of several serum lipids as predictors of coronary heart disease. The Framingham Study. Ann Intern Med 1964; 61: 888-93.
2. Stamler J, Stamler R, Fiu K. High blood pressure: role in coronary heart disease and implications for prevention and control. In: Connor W. Bristow D, eds. Coronary heart disease. Philadelphia: J. B. Lippincott. 1985:85-109.
3. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990; 39: 167-74.
4. Pollare T, Lithell H, Selinus I, Berne C. Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. Br Med J 1989; 298: 1152-7.
5. Pollare T, Lithell H, Mörlin C, Prantare H, Hvarfner A, Ljunghall S. Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind studv with parallel groups. J Hypertens 1989; 7: 551-9.
6. Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 1989; 321: 868-73.
7. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: 214-23.
8. Siegler L, Wu WT. Separation of serum high-density lipoprotein for cholesterol determination: ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride. Clin Chem 1981; 27: 838-41.
9. Furman BL. Impairment of glucose tolerance produced by diuretics and other drugs. Pharmacol Ther 1981; 12: 613-49.
10. Grunfeld C, Chappell DA. Hvpokalemia and diabetes mellitus. Am J Med 1983; 75: 553-4.
11. Frerichs H, Creutzfeld W. Insulin release from pancreas of the rat, the rabbit, and miniature-pig in-vitro. Piabetologia 1965; 1: 80.
12. Rowe JW, Tobin JD, Rosa RM, Andres R. Effects of experimental potassium deficiency on glucose and insulin metabolism. Metabolism 1980; 29: 498-502.
13. Helderman JH, Elahi D, Andersen DK, et al. Prevention of glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes 1983;32:106-11.
14. Barnett CA, Whitney JE. The effect of diazoxide and chlorothiazide on glucose uptake in-vitro. Metabolism 1966; 15: 88-93.
15. Grimm RH Jr, Leon AS, Hunninghake DB, Lenz K, Hannan P, Blackburn H. Effects of thiazide diuretics on plasma lipids and lipoproteins in mildly hypertensive patients: a doubleblind controlled trial. Ann Intern Med 1981;94:7-11.
16. Ames RP, Hill P. Elevation of serum lipids during diuretic therapy for hypertension. Am J Med 1976; 61: 748-57.
17. Schoenfeld R, Goldberger E. Hypercholesterolemia induced by thiazides: a pilot study. Curr Ther Res 1964; 6: 180.
18. Weinberger MH. Influence of an angiotensin converting enzyme inhibitor on diuretic-induced metabolic effects in hypertension. Hypertension 1983;5(suppl III):132-8.
19. Ferrannini E, Buzzigoli G, Bonudonna R, et al. Insulin resistance in essential hypertension. N Engl J Med 1987; 317: 350-7.
20. Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. Effect of insulin and glucose infusions on sympathetic nervous svstem activity in normal man. Diabetes 1981; 30: 219-25.
21. DcFronzo RA. Effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia 1981; 21: 165-71.
22. Berne C, Fagius J, Niklasson F. Sympathetic response to oral carbohydrate administration. Evidence from microelectrode nerve recordings. J Clin Invest 1989; 84: 1403-9.