Rational design of peptide-based HIV proteinase inhibitors

Science

Volumn 248, Issue 4953, 1990, Pages 358-361

  Roberts, Noel A ^a   Martin, Joseph A ^a   Kinchington, Derek ^b   Broadhurst, Anne V ^a   Craig, J Charles ^a   Duncan, Ian B ^a   Galpin, Sarah A ^b   Handa, Balraj K ^a   Kay, John ^c   Kröhn, Antonin ^a   Lambert, Robert W ^a   Merrett, John H ^a   Mills, John S ^a   Parkes, Kevin E B ^a   Redshaw, Sally ^a   Ritchie, Alison J ^a   Taylor, Debra L ^d   Thomas, Gareth J ^a   Machin, Pemer J ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

PROTEINASE INHIBITOR;

ARTICLE; CELL CULTURE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CELL LINE; COMPARATIVE STUDY; DRUG DESIGN; ENDOPEPTIDASES; GENE PRODUCTS, GAG; GENE PRODUCTS, POL; HIV PROTEASE; HIV-1; HIV-2; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0025268321     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.2183354     Document Type: Article

References (0)