Mechanisms of Multidrug Resistance in HL60 Cells: Detection of Resistance-associated Proteins with Antibodies against Synthetic Peptides That Correspond to the Deduced Sequence of P-Glycoprotein

Cancer Research

Volumn 50, Issue 5, 1990, Pages 1426-1430

  Marquardt, David ^a   McCrone, Sue ^a   Center, Melvin S ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; RADIOISOTOPE; SYNTHETIC PEPTIDE; VINCRISTINE;

ARTICLE; CELL CULTURE; CELL STRAIN HL 60; DRUG RESISTANCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTIBODIES; BASE SEQUENCE; CARRIER PROTEINS; DRUG RESISTANCE; HUMAN; LEUKEMIA, NONLYMPHOCYTIC, ACUTE; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; P-GLYCOPROTEIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0025267059     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Biedler, J. L., and Riehm, H. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radiographic and cytogenetic studies. Cancer Res., 30:1174–1184, 1970.
2. Ling, V., and Thompson, L. H. Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J. Cell Physiol., 83: 103–111, 1974.
3. Inaba, M., Kobayashi, H., Sakurai, Y., and Johnson, R. K. Active efflux of daunorubicin and Adriamycin in sensitive and resistant sublines of P388 leukemia. Cancer Res., 39: 2200–2203, 1979.
4. Skovsgaard, T. M. Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells. Cancer Res., 38:1785–1791, 1978.
5. Juliano, R. L., and Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochem. Biophys. Acta, 455: 152–162, 1976.
6. Peterson, R. H. F., and Biedler, J. L. Plasma membrane proteins and glycoproteins in Chinese hamster cells sensitive and resistant to actinomycin D. J. Supramol. Struct., 9: 289–298, 1978.
7. Beck, W. T., Mueller, T. J., and Tanzer, L. R. Altered surface membrane glycoproteins in Vinca alkaloid resistant human leukemic lymphoblasts. Cancer Res., 39:2070–2076, 1979.
8. Garman, D., and Center, M. S. Alterations in cell surface membranes in Chinese hamster lung cells resistant to Adriamycin. Biochem. Biophys. Res. Commun., 105:157–163, 1982.
9. Gros, P., Ben Neriah, Y., Croop, J. M., and Housman, D. E. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (Lond.), 323:728–731, 1986.
10. DeBruijn, M. L., Van der Bliek, A. M., Biedler, J. L., and Borst, P. Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines. Mol. Cell. Biol., 6: 4717–4722, 1986.
11. Endicott, J. A., Juranka, P. F., Saranqi, F., Gerbach, H. J., Deuchars, K. L., and Ling, V. Simultaneous expression of two P-glycoprotein genes in drug sensitive Chinese hamster ovary cells. Mol. Cell. Biol., 7: 4075–4081, 1987.
12. Chen, C., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. Internal duplication and homology with bacterial transport proteins in the mdr\ gene from multidrug-resistant human cells. Cell, 47:381–389, 1986.
13. Van der Bliek, A. M., Baas, F., Teu Haute de Lange, T., Kooiman, P. M., Van der Velde-Koerts, T., and Borst, P. The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J., 6: 3325–3331, 1987.
14. Bhalla, K., Hindenburg, A., Taub, R. N., and Grant, S. Isolation and characterization of an anthracycline-resistant human leukemic cell line. Cancer Res., 45: 3657–3662, 1985.
15. Marsh, W., Sicheri, R., and Center, M. S. Isolation and characterization of Adriamycin-resistant HL60 cells which are not defective in the initial intracellular accumulation of drug. Cancer Res., 46:4053–4057, 1986.
16. McGrath, T., Latoud, C., Arnold, S. T., Safa, A. R., Felsted, R. L., and Center, M. S. Mechanisms of multidrug resistance in HL60 cells: analysis of resistance associated membrane proteins and levels of mdr gene expression. Biochem. Pharmacol., 38:3611–3619, 1989.
17. McGrath, T., and Center, M. S. Adriamycin resistance in HL60 cells in the absence of detectable P-glycoprotein. Biochem. Biophys. Res. Commun., 745:1171–1176, 1987.
18. Marsh, W., and Center, M. S. Adriamycin resistance in HL60 cells and accompanying modification of a surface membrane protein contained in drug-sensitive cells. Cancer Res., 47: 5080–5086, 1987.
19. Gervasoni, J. E., Taub, R. N., Rosado, M., Krishna, S., Lutzky, J., Remmick, R. A., Baker, M. A., and Hindenburg, A. A. Surface membrane glycoprotein alterations associated with multidrug resistance in a P-glycoprotein negative cell line. Proc. Am. Assoc. Cancer Res., 30: 506, 1989.
20. McGrath, T., and Center, M. S. Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug. Cancer Res., 48:3959–3963, 1988.
21. Cornwall, M. M., Tsuruo, T., Gottesman, M. M., and Pastan, I. ATP binding properties of P-glycoprotein from multi-drug resistant KB cells. FASEB J., 7:51–54, 1987.
22. Marglin, A., and Merrifield, R. B. Chemical synthesis of peptides and proteins. Annu. Rev. Biochem., 39:841–866, 1970.
23. Mumby, S. A., Kahn, R. A., Manning, D. R., and Gilman, A. G. Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc. Natl. Acad. Sci. USA, 83: 265–269, 1986.
24. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227:680–685, 1970.
25. Towbin, H., Staehelin, T., and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: procedure and some applications. Proc. Natl. Acad. Sci. USA, 76:4353–4354, 1979.
26. Garman, D., Alters, L., and Center, M. S. Identification and characterization of a plasma membrane phosphoprotein which is present in Chinese hamster lung cells resistant to Adriamycin. Biochem. Pharmacol., 32: 3622–3627, 1983.
27. Kartner, N., Evernden-Porelle, D., Bradley, G., and Ling, V. Detection of P-glycoprotein in multidrug resistant cell lines by monoclonal antibodies. Nature (Lond.), 316:820–823, 1985.
28. Fry, D. C., Kuby, S. A., and Mildvan, A. S. NMR studies of the MgATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme. Biochemistry, 24:4680–4694, 1985.
29. Slovak, M. L., Hoeltge, G. A., Dalton, W. S., and Trent, J. M. Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res., 48:2193–2191, 1988.