Mitochondrial Complex I Deficiency in Parkinson's Disease

Journal of Neurochemistry

Volumn 54, Issue 3, 1990, Pages 823-827

  Schapira, A H V ^a   Cooper, J M ^a   Dexter, D ^a   Clark, J B ^a   Jenner, P ^a   Marsden, C D ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Complex I; Mitochondria; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

ARTICLE; AUTOPSY; CLINICAL ARTICLE; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

HUMAN; MITOCHONDRIA; MULTIENZYME COMPLEXES; NAD(P)H DEHYDROGENASE (QUINONE); OXIDOREDUCTASES; PARKINSON DISEASE; QUINONE REDUCTASES; SUBSTANTIA NIGRA; SUCCINATE DEHYDROGENASE; SUPPORT, NON-U.S. GOV'T; UBIQUINOL-CYTOCHROME-C REDUCTASE;

ANIMALIA;

EID: 0025254401     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1990.tb02325.x     Document Type: Article

References (37)

1. Animal mitochondrial DNA, an extreme example of genetic economy
2. Role of metals in oxygen radical reactions
3. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by MPTP
4. Paraquat: model for oxidant‐initiated toxicity
5. Functional assignment of the unidentified reading frames of human mitochondrial DNA
6. Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones
7. Chronic parkinsonism secondary to intravenous injection of meperidine analogues
8. A dopaminergic cell line variant resistant to the neurotoxin MPTP
9. Increased nigral iron content in postmortem parkinsonian brain
10. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
11. Free radicals, lipid peroxidation and MPTP‐induced parkinsonism
12. 3H]dihydrorotenone
13. Reoxygenation of perfused hypoxic heart causes a mitochondrial Complex I defect
14. Preparation and properties of DPNH‐coenzyme Q reductase
15. Dopaminergic toxicity of rotenone and the MPP ion after their stereotaxic administration to rats: implication for the mechanism of MPTP toxicity
16. Deletions of mitochondrial DNA in patients with mitochondrial myopathy
17. + by dopamine neurons explains selective toxicity
18. 1 particle, and reconstitution of succinate cytochrome c reductase
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Chronic parkinsonism in humans due to a product of meperidine‐analog synthesis
21. MPTP causes selective damage to the zona compacta of the substantia nigra in the squirrel monkey
22. Protein measurement with the Folin phenol reagent
23. Molecular defects of NADH‐ubiquinone oxidoreductase (Complex I) in mitochondrial diseases
24. +, a metabolite of the neurotoxin MPTP
25. The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals
26. Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light
27. Subfractionation of mitochondria and isolation of the proteins of oxidative phosphorylation
28. +, the neurotoxic metabolite of MPTP, by mitochondria
29. + by brain mitochondria mediates the neurotoxicity of MPTP
30. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
31. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and free radicals in vitro
32. Oxidation of the neurotoxic amine MPTP by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP
33. Molecular basis of mitochondrial myopathies: polypeptide analysis in Complex I deficiency
34. Mitochondrial Complex I deficiency in Parkinson's disease
35. Biochemical events in the development of parkinsonism induced by MPTP
36. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
37. Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens