Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin

Drug Metabolism and Disposition

Volumn 18, Issue 2, 1990, Pages 218-222

  Vyas, K P ^a   Kari, P H ^a   Prakash, S R ^a   Duggan, D E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DICHLORO 6 PHENYLPHENOXY)ETHYLAMINE; CYTOCHROME P450; DRUG METABOLITE; METYRAPONE; MEVINOLIN; PROADIFEN; RADIOISOTOPE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ARTICLE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; IN VITRO; LOVASTATIN; MALE; METYRAPONE; MICE; MICROSOMES, LIVER; NADP; POLYCHLORINATED BIPHENYLS; PROADIFEN; RATS; SPECIES SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA;

EID: 0025248279     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)