Equivalent helper functions of human "naive" and "memory" CD4+ T cells for the generation of alloreactive cytotoxic T lymphocytes

Journal of Clinical Immunology

Volumn 10, Issue 5, 1990, Pages 237-246

  Yamashita, Naomi ^a   Bullington, Robin ^a   Clement, Loran T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD4+ cells; CD45RA antigen; Helper T cell subsets; immune regulation

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; IMMUNOREGULATION; PRIORITY JOURNAL;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD45; ANTIGENS, CD8; ANTIGENS, DIFFERENTIATION; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HISTOCOMPATIBILITY ANTIGENS; HUMAN; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERLEUKIN-2; KINETICS; LYMPHOCYTE ACTIVATION; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0025247035     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/BF00916699     Document Type: Article

References (40)

1. Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man
2. Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations
3. Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-Leu-8
4. Human lymphocyte differentiation antigens HB-10 and HB-11. I. Ontogeny of antigen expression
5. Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations
6. The isolation and characterization of the human suppressor inducer T cell subset
7. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1
8. Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
9. Two types of mouse helper T cell clones. Implications for immune regulation
10. In vitro activation of murine antigen-specific memory B cells by a T-dependent antigen
11. Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using a class II-restricted antigen-specific, IL-2-dependent helper T cell clone
12. Characterization of a phenotypically distinct subpopulation of Leu-2+ cells that suppresses T cell proliferative responses
13. The functionally distinct subpopulations of human helper/inducer T lymphocytes defined by anti-CD45RA antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation
14. Phenotypic characterization of the post-thymic differentiation of human alloantigen-specific CD8+ cytotoxic T lymphocytes
15. Characterization of human lymphocyte subpopulations: Alloreactive cytotoxic T lymphocyte precursor and effector cells are phenotypically distinct from Leu-2+ suppressor cells
16. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells
17. Generation of CD8 (T8) cytotoxic cells has a preferential requirement for CD4 + 2H4− inducer cells
18. Helper cell-independent cytotoxic clones in man
19. Recognition requirements for the activation, differentiation, and function of T helper cells specific for class I MHC alloantigens
20. Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus
21. Human naive and memory T cells: Reinterpretation of helper-inducer and suppressor-inducer subsets
22. Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event
23. T cell regulation of human B cell proliferation and differentiation. Regulatory influences of CD45R + and CD45R - T4 cell subsets
24. Identification and isolation of OKT4+ suppressor cells with the monoclonal antibody WR16
25. Monoclonal antibody directed against interleukin 2. I. Inhibition of T lymphocyte mitogenesis and the in vitro differentiation of alloreactive cytotoxic T cells
26. Dissection of the proliferative and differentiation signals controlling murine cytotoxic T lymphocyte responses
27. Interferon: A cytotoxic T lymphocyte differentiation signal
28. IL-2 and IFN-g are two necessary lymphokines in the development of cytolytic T cells
29. Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor
30. B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors
31. Interleukin 5, a T-cell derived B-cell differentiation factor also induces cytotoxic T lymphocytes
32. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes
33. IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells
34. T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor
35. Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes
36. Effects of treatment with IL-2 receptor specific monoclonal antibody in mice. Inhibition of cytotoxic T cell responses but not of T help
37. Human memory lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-g production
38. Characterization of a monocyte differentiation factor distinct from gamma-interferon, tumor necrosis factor, or G,M-colony stimulating factor that regulates the growth and functional capabilities of the U937 monocytic cell line
39. Simultaneous production of IL-2, IL-4, and IFN-g by activated human CD4+ and CD8+ T cell clones
40. Interleukin 2-mediated immune interferon production by human T cells and T cel subsets