Human nicotinic acetylcholine receptor: the influence of second messengers on activation and desensitization

Pflügers Archiv: European Journal of Physiology

Volumn 415, Issue 6, 1990, Pages 701-706

  Siara, J ^a   Ruppersberg, J P ^a,b   Rudel R ^a  

^a UNIVERSITY OF ULM   (Germany)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Acetylcholine receptor; Calcium; cAMP dependent protein kinase; Desensitization; Human nerve cells

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR; CYCLIC AMP;

ARTICLE; CELL CULTURE; DESENSITIZATION; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; PRIORITY JOURNAL; SECOND MESSENGER;

ACETYLCHOLINE; CALCIUM; CYCLIC AMP; EXTRACELLULAR SPACE; HUMAN; INTRACELLULAR MEMBRANES; OSMOLAR CONCENTRATION; PROTEIN KINASES; RECEPTORS, NICOTINIC; SECOND MESSENGER SYSTEMS; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0025236771     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/BF02584008     Document Type: Article

References (29)

1. A possible involvement of cAMP in the expression of desensitization of the nicotinic acetylcholine receptor
2. 2+ do in cells?
3. Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers
4. Reconstitution of a functional acetylcholine regulator under defined conditions
5. The role of protein phosphorylation in neuronal and hormonal control of cellular activity
6. Effect of ionophore X-537A on desensitization rate and tension development in potassium-depolarized muscle fibres
7. Inactivation of human sodium channels and the effects of tocainide
8. What can we learn about the acetylcholine receptor from synthetic peptides?
9. + conductance of human red cells as revealed by the patch clamp technique
10. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches
11. Regulation of the cardiac Ca channel by protein phosphatases
12. Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosinspecific protein kinase
13. Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization
14. Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel
15. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
16. A study of the desensitization produced by acetylcholine at the neuromuscular junction
17. Phosphorylation of ion channels
18. Desensitization in denervated mouse muscles
19. A muscle acetylcholine receptor is expressed in the human cerebellar modulloblastoma cell line TE671
20. Establishment of a human medulloblastoma cell line
21. Molecular aspects of the trophic influence of nerve on muscle
22. Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
23. Phosphorylation of the nicotinic cholinergic receptor increases the probability of channel opening
24. Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein
25. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist
26. Human acetylcholine receptors desensitize much faster than rat acetylcholine receptors
27. Studies of the composition of purified torpedo californica acetylcholine receptor and of its subunits
28. Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMP
29. Angiotension II increases cytosolic calcium and stimulates catecholamine release in cultured bovine adrenomedullary cells