Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis

Gastroenterology

Volumn 98, Issue 4, 1990, Pages 976-984

  Lombard, M ^a,b   Bomford, A B ^a,b   Polson, R J ^a,b   Bellingham, A J ^a,b   Williams, Roger ^a,b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b School of Medicine and Dentistry   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFERRIN;

ANEMIA; ARTICLE; DUODENUM MUCOSA; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; IRON TRANSPORT; MEMBRANE TRANSPORT; PRIORITY JOURNAL;

ADULT; DUODENUM; FEMALE; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; IRON; MALE; MIDDLE AGE; RECEPTORS, TRANSFERRIN; SUPPORT, NON-U.S. GOV'T;

EID: 0025233620     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(90)90022-S     Document Type: Article

References (49)

1. Absorption and excretion of iron
2. Studies in iron absorption VI. Transitory effect of oral administration of iron on iron absorption
3. Iron absorption and loading in β-thalassemia intermedia
4. Iron absorption in idiopathic haemochromatosis before during and after venesection therapy
5. The importance of free radicals and catalytic metal ions in liver disease
6. Transferrin and its receptor: their roles in cell function
7. Ubiquitous cell surface glycoprotein on tumour cells is proliferation associated receptor for transferrin
8. Regulation of transferrin receptors in human haematopoietic cell lines
9. Regulation of K562 cell transferrin receptors by exogenous iron
10. Regulation of the hepatic transferrin receptor in hereditary hemochromatosis
11. 4
12. Uptake of iron by duodenal biopsy specimens from patients with iron deficiency anaemia and primary haemochromatosis
13. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine
14. The turnover of the epithelium of the small intestine
15. Method for the automatic determination of serum iron
16. Ferritin in serum: clinical and biochemical implications
17. Heredity of idiopathic haemochromatosis
18. Histocompatibility antigens as markers of abnormal iron metabolism in patients with idiopathic haemochromatosis and their relatives
19. Hereditary haemochromatosis: phenotypic expression of the disease
20. The genetics of haemochromatosis
21. Haemochromatosis; 1980 update
22. Lack of hepatic transferrin receptor expression in hemochromatosis
23. Transferrin receptors on circulating monocytes in hereditary haemochromatosis
24. Iron uptake and ferritin synthesis by peripheral blood leucocytes in patients with primary idiopathic haemochromatosis
25. Ferritin synthesis in peripheral blood monocytes in idiopathic haemochromatosis
26. Transferrin receptor function in hereditary haemochromatosis
27. The ultrastructural immunocytochemical localisation of transferrin receptor and transferrin in the gastrointestinal tract of man (abstr)
28. Ultrastructural localisation of transferrin, transferrin receptor and iron-binding sites in human placental and duodenal microvilli
29. The role of the intestine in iron kinetics
30. Intestinal mucosal mechanisms controlling iron absorption
31. Iron uptake by isolated intestinal brush borders: changes induced by alterations to iron stores
32. Iron absorption: the effect of an iron-deficient diet
33. Effect of transferrin saturation on iron absorption in man
34. Transferrin receptors in the human gastrointestinal tract. Relationship to body iron stores
35. The iron content of jejunal mucosa obtained by Crosby's capsule in haemochromatosis and haemosiderosis
36. Iron content of isolated intestinal epithelial cells in relation to iron absorption
37. The iron content of intestinal epithelial cells and its subcellular distribution: studies in normal iron overload and iron deficient rats
38. Protein apoferritin and ferritin in iron feeding and absorption
39. Internal regulation of iron absorption
40. Iron absorption present state of the art
41. Expression of human transferrin receptor is controlled by a gene on chromosome 3: assignment using species specificity of a monoclonal antibody
42. Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelioid cells in idiopathic hemochromatosis
43. Duodenal iron proteins in idiopathic haemochromatosis
44. Transferrin receptor regulation is coupled to intracellular ferritin in proliferating and differentiating HL60 leukaemic cells
45. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNA's
46. Iron-responsive elements: regulatory DNA sequences that control mRNA levels and translation
47. A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor
48. Oxidationreduction and the molecular mechanism of a regulatory RNA-protein interaction