Mechanisms of platelet activation and inhibition

Hematology/Oncology Clinics of North America

Volumn 4, Issue 1, 1990, Pages 1-26

  Ashby, B ^a   Daniel, J L ^a   Smith, J B ^a  

^a Temple University Health Sciences Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR;

HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; STIMULUS SECRETION COUPLING; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOEMBOLISM;

EID: 0025228516     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0889-8588(18)30503-3     Document Type: Review

References (170)

1. R.S. Adelstein M.A. Conti Phosphorylation of platelet myosin increases actin- activated myosin ATPase activity Nature 256 1975 597
2. 2∼ release from human platelet membranes Biochem Biophys Res Commun 128 1985 1274
3. B. Ashby Kinetic evidence indicating separate stimulatory and inhibitory pros taglandin receptors on platelet membranes J Cyclic Nucleotide Protein Phosphor Res 11 1986 291
4. B. Ashby Cyclic AMP turnover in response to prostaglandins in intact platelets: Evidence for separate stimulatory and inhibitory prostaglandin receptors Second Messengers Phosphoproteins 12 1988 45
5. 2+ from highly purified human platelet intracellular membranes Biochem J 230 1985 247
6. I.R. Batty S.R. Nahorski R.F. Irvine Rapid formation of inositol 1,3,4,5-tetrakisphos- phate following muscarinic receptor stimulation of rat cerebral cortical slices Biochem J 232 1985 211
7. H.R. Baumgartner G.V.R. Born Effects of 5-hydroxytryptamine on platelet aggregation Nature 231 1968 235
8. R.L. Bell D.A. Kennerly N. Stanford Diglyceride lipase-pathway for arachi- donic acid release from human platelets Proc Natl Acad Sei USA 76 1979 3238
9. J. Benveniste P.M. Henson C.G. Cochrane Leukocyte-dependent histamine release from rabbit platelet: The role of IgE basophils and a platelet-activating factor J Exp Med 136 1972 1356
10. M.J. Berridge R.F. Irvine Inositol trisphosphate, a novel second messenger in cellular signal transduction Nature 312 1984 315
11. 2 Nature 315 1985 511
12. M.M. Billah E.G. Lapetina P. Cuatrecasas Phosphatidylinositol-specific phospholi pase C of platelets: Association with 1,2-diacylglycerol kinase and inhibition by cyclic AMP Biochem Biophys Res Commun 90 1979 92
13. T.K. Bills J.B. Smith M.J. Silver Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin J Clin Invest 60 1977 1
14. G.V.R. Born K. Juengjaroen F. Michal Relative activities and uptake by human blood platelets of 5-hydroxytryptamine and several analogues Br J Pharmacol 44 1972 117
15. H.R. Bourne S.B. Masters K.A. Sullivan Mammalian G proteins: Structure and function Biochem Soc Trans 15 1987 35
16. P. Braquet T.Y. Shen L. Touqui Perspectives in platelet-activating factor research Pharmacol Rev 39 1987 97
17. 2+ mobilization and granule secretion in platelets J Biol Chem 260 1985 15172
18. L.F. Brass M. Laposta H.S. Banga Regulation of the phosphoinositide hydroly sis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein Evaluation of its contribution to platelet activation and comparison with the adenylate cyclase inhibitory protein J Biol Chem 261 1986 16838
19. M.E. Bromberg R.W. Sevy J.L. Daniel Role of myosin phosphorylation in contractility of a platelet aggregate Am J Physiol 249 1985 C297
20. J. Bryan M.C. Kurth Actin-gelsolin interactions. Evidence for two actin-binding sites J Biol Chem 259 1984 7480
21. G.L. Bundy The synthesis of prostaglandin endoperoxide analogs Tetrahedron Lett 24 1975 1957
22. I.F. Charo R.D. einman T.C. Detwiler Inhibition of platelet secretion by an antagonist of intracellular calcium Biochem Biophys Res Commun 72 1976 1462
23. W.Y. Cheung Calmodulin plays a pivot role in cellular regulation Science 207 1980 19
24. T.M. Chiang S.N. Dixit A.H. Kang Effect of cyclic 3′,5′-guanosine monophosphate on human platelet function J Lab Clin Med 88 1976 215
25. M. Chignard J.P. Le Couedie M. Tence The role of platelet-activating factor in platelet aggregation Nature 275 1979 799
26. P. Cohen A. Derksen Comparison of phospholipid and fatty acid composition of human erythrocytes and platelets Br J Haematol 17 1969 359
27. N.C. Collier K. Wang Purification and properties of human platelet P235: A high molecular weight protein substrate of endogenous calcium-activated protease(s) J Biol Chem 257 1982 6937
28. T.M. Connolly W.J. Lawing Jr. P.W. Majerus Protein kinase C phosphorylates human platelet inositol trisphosphate 5′ monoesterase, increasing the phosphatase activity Cell 46 1986 951
29. M.A. Conti R.S. Adelstein The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3′,5′cAMP-dependent protein kinase J Biol Chem 256 1981 3178
30. E.J. Corey K.C. Nicolaou Y. Machida Synthesis and biological properties of a 9,11-azo-prostanoid: Highly active biochemical mimic ofprostaglandin endoper- oxides Proc Natl Acad Sei USA 72 1975 3355
31. 2+- and modulator-dependent myosin light chain kinase from non-muscle cells Biochem Biophys Res Commun 85 1978 1352
32. 32P]orthophosphate-labeled platelets Anal Biochem 154 1986 414
33. J.L. Daniel C.A. Dangelmaier J.B. Smith Formation and metabolism of inositol trisphosphate in human platelets Biochem J 246 1987 109
34. J.L. Daniel C.A. Dangelmaier J.B. Smith Calcium modulates the generation of inositol 1,3,4-trisphosphate in human platelets by the activation of inositol trisphosphate 3-kinase Biochem J 253 1988 789
35. J.L. Daniel H. Holmsen R.S. Adelstein Thrombin-stimulated myosin phosphorylation in intact platelets—its possible involvement in secretion Thromb Haemostasis 38 1977 984
36. J.L. Daniel I.R. Molish H. Holmsen Myosin phosphorylation in intact platelets J Biol Chem 256 1980 7510
37. J.L. Daniel I.R. Molish M. Rigmaiden Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response J Biol Chem 259 1984 9826
38. J.L. Daniel M.A. Selak A.D. Purdon Methods for the study of the role of calcium in platelet function R.W. Colman J.B. Smith Methods for Studying Platelets and Megakaryocytes. Modern Methods in Pharmacology. Volume 4 1987 Alan R. Liss New York 185
39. H. Darius V. Hossmann H. Auel Hemodynamic and platelet effects ofiloprost (ZK36.373) in patients with peripheral aterial disease K. Schror Prostaglandins Other Eicosanoids in the Cardiovascular System 1985 Karger Basel 392
40. F. De Clerk J.L. David P.A.J. Janssen Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41,468) a selective 5-HT2 antagonist Agents Actions 12 1982 383
41. T.C. Detwiler Control of energy metabolism in platelets. The effects of thrombin and cyanide on glycolysis Biochim Biophys Acta 256 1972 163
42. A.K. Dutta Roy A.K. Sinha Purification and properties of prostaglandin ER prostacyclin receptor of human blood platelets J Biol Chem 262 1987 12685
43. B. Faitag I. Bondard J. Duloroy Effect of ketanserin on bleeding time: A comparison with aspirin Thromb Res 44 1986 261
44. R.D. Feinman T.C. Detwiler Platelet secretion induced by divalent cation ion-ophores Biochim Biophys Acta 249 1974 172
45. 2 and forskolin J Biol Chem 258 1983 1260
46. M.B. Feinstem J.J. Egan R.I. Shaafi The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2 PGE1, forskolin) Biochem Biophys Res Commun 113 1983 598
47. W.R. Figures S. Niewiarowski T.A. Morinelli Affinity labeling of a human platelet membrane protein with 5′-p-fluorosulfonylbenzoyl adenosine J Biol Chem 256 1981 7789
48. J.E. Fox C.C. Reynolds M.M. Johnson Identification of glycoprotein lb beta as one of the major proteins phosphorylated during exposure of intact platelets to agents that activate cyclic AMP-dependent protein kinase J Biol Chem 262 1987 12627
49. A. Gaarder J. Jonsen S. Laland Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets Nature 192 1961 531
50. A.G. Gilman G-proteins and dual control of adenylate cyclase Cell 36 1984 577
51. G. Gough M.H. Maguire F. Penglis Analogues of adenosine 5′-diphosphate—New platelet aggregators Mol Pharmacol 8 1972 170
52. P.G. Grant R.W. Colman Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase Biochemistry 23 1984 1801
53. P.G. Grant R.W. Colman Purification of cAMP phosphodiesterase from platelets Methods Enzymol 159 1988 772
54. P.G. Grant A.F. Mannarino R.W. Colman cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity Proc Natl Acad Sei USA 85 1988 9071
55. K. Grette Studies on the mechanism of thrombin-catalysed hemostatic reactions in blood platelets Acta Physiol Scand 56 195 1962 1
56. T.J. Hallam J.L. Daniel J. Kendrick-Jones Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets Biochem J 232 1985 373
57. M. Hamberg J. Svensson B. Samuelsson Thromboxanes—a new group of biologically active compounds derived from prostaglandin endoperoxides Proc Natl Acad Sei USA 72 1975 2994
58. M. Hamberg J. Svensson T. Wakabayashi Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation Proc Natl Acad Sei USA 71 1974 345
59. D.J. Hanahan C.A. Demopoulos J. Liehr Identification of platelet activating factor isolated from rabbit J Biol Chem 255 1980 5514
60. R.M. Hardisty R.A. Hutton Bleeding tendency associated with “new” abnormality of platelet behavior Lancet 1 1967 983
61. R.J. Has lam M.L. Davidson J.V. Desjardins Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact platelets Biochem J 176 1978 83
62. 2+] required for secretion of serotonin from permeabilized blood platelets. Evidence of a role for a GTP-binding protein in platelet activation FEBS Lett 174 1984 90
63. 2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation Biochem J 222 1984 351
64. R.J. Haslam M.M. Davidson Receptor-induced diacylglycerol formation in perme abilized platelets; possible role for a GTP-binding protein J Recept Res 4 1984 605
65. R.J. Haslam J.A. Lynham J.E.B. Fox Effects of collagen, ionophore A23187 and prostaglandin Eļ on the phosphorylation of specific proteins in blood platelets Biochem J 178 1979 397
66. D.R. Hathaway R.S. Adelstein Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity Proc Natl Acad Sei USA 76 1979 1653
67. D.J. Hawkins B.O. Meyrick J.J. Murray Activation of guanylate cyclase and inhibition of platelet aggregation by endothelium-derived relaxing factor released from cultured cells Biochim Biophys Acta 969 1988 289
68. H. Hidaka T. Asano Human blood platelet 3′ :5′-cyclic nucleotide phosphodiesterase. Isolation of low-Km and high-Km phosphodiesterase Biochim Biophys Acta 429 1976 485
69. L.E. Hokin M.R. Hokin Effects of acetylcholine on phosphate turnover in phospho lipids of brain cortex in vitro Biochim Biophys Acta 16 1955 229
70. H. Holmsen H.J. Day E. Storm Adenine nucleotide metabolism of blood platelets. VI. Subcellular localization of nucleotide pools with different functions in the platelet Biochim Biophys Acta 186 1969 254
71. W.C. Horne N.E. Norman D.B. Schwartz Changes in cytoplasmic pH and membrane potential in thrombin-stimulated human platelets Eur J Biochem 120 1981 295
72. E.M. Huang T.C. Detwiler Stimulus-response coupling mechanisms D.R. Phillips M.A. Shuman Biochemistry of Platelets 1986 Academic Press New York 1
73. T. Imaoka T. Asaji Platelet 47K phosphoprotein may not function as inositol phos phate 5-monoesterase and lipocortin FASEB J 3 1989 A1287
74. D.M. Ireland Effect of thrombin on the radioactive nucleotides of human washed platelets Biochem J 105 1967 857
75. R.F. Irvine A.J. Letcher D.J. Lander Inositol trisphosphates in carbachol- stimulated rat parotid glands Biochem J 223 1984 237
76. R.F. Irvine R.M. Moor W.K. Pollock Inositol phosphates: Proliferation metabolism function Philos Trans R Soc L.ond B 320 1988 281
77. H. Ishii T.M. Connolly T.E. Bross Inositol cyclic triphosphate [inositol l, 2(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets Proc Natl Acad Sei USA 83 1986 6397
78. K. Kaibuchi Y. Takai M. Sawamura Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation J Biol Chem 258: 1983 6701
79. 2+- accumulating vesicles Biochim Biophys Acta 558 1979 344
80. R. Kaser-Glanzmann M. Jakabova J.N. George Stimulation of calcium uptake in platelet membrane vesicles by adenosine cyclic 3′.5′-monophosphate and protein kinase Biochim Biophys Acta 466 1977 429
81. T. Katada G.M. Bokoch J.K. Northup The inhibitory guanine nucleotide binding regulatory component of adenylate cyclase. Properties and function of the purified protein J Biol Chem 259 1984 3568
82. R.L. Kinlough-Rathbone M.A. Packham H.J. Reimers Mechanisms of platelet shape change, aggregation and release induced by collagen, and release induced by collagen, thrombin or A23187 J Lab Clin Med 90 1977 707
83. A. Kishimoto Y. Takai M. Terutoshi Activation of calcium and phospholipid- dependent protein kinase by diacylglycerol, its possible relation to phospha- tidylinositol turnover J Biol Chem 255 1980 2273
84. 2+-mediated secretion Nature 296 1982 256
85. 2+ Eur J Biochem 143 1984 437
86. 2+ in amine storage granule secretion by human platelets Thromb Res 20 1980 437
87. 2-adrenergic receptor Science 238 1987 650
88. J.J. Kocsis J. Hernandovich M.J. Silver Duration of inhibition of platelet prostaglandin formation and aggregation by ingested aspirin or indomethacin Prostaglandins 3 1973 141
89. 2 Biochim Biophys Acta 878 1986 394
90. 2 by diacylglycerol Biochem J 248 1987 779
91. M.C. Kurth J. Bryan Platelet activation induces the formation of a stable gelsolin-actin complex from monomeric gelsolin J Biol Chem 259 1984 7473
92. E.A. Lebowitz R. Cooke Contractile properties of actomyosin from human blood platelets Biol Chem 253 1978 5443
93. 2 Proc Natl Acad Sei USA 77 1980 1706
94. H.D. Lewis J.W. Davis D.G. Archibald Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina N Engl J Med 309 1983 396
95. 3H]ketanserin Eur J Pharmacol 256 1983 11330
96. 32P-content of phosphatidic acid and the phosphoinositides of rabbit platelets during aggregation induced by collagen or thrombin Br J Haematol 26 1974 243
97. D.E. Macfarlane D.C.B. Mills The effects of ATP on platelets: Evidence against the central role of released ADP in primary aggregation Blood 46 1975 309
98. 32P]di- phosphate to the receptor on intact human blood platelets which inhibits adenylate cyclase Biochemistry 21 1982 544
99. D.C. Macmillan Secondary clumping effect in human citrated platelet-rich plasma produced by adenosine diphosphate and adrenaline Nature 211 1966 140
100. C.H. Macphee D.H. Reifsnyder T.A. Moore Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets J Biol Chem 263 1988 10353
101. P. Massini E.F. Luscher Some effects of ionophores for divalent cations on blood platelets Biochim Biophys Acta 372 1974 109
102. s activate both adenylyl cyclase and calcium channels Science 243 1989 804
103. E.B. McGowan E. Becker T.C. Detwiler Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d Biochem Biophys Res Commun 158 1989 432
104. D.E. McIntyre Platelet prostaglandin receptors J.L Gordon Platelets in Biology Pathology 2. 1981 Elsevier/North Holland Biomedical Press Amsterdam P211
105. F. Michal D-receptor for serotonin on blood platelets Nature 221 1969 140
106. F. Michal F. Penglis Inhibition of serotonin-induced platelet aggregation in relation to thrombus formation J Pharmacol Exp Ther 166 1969 276
107. O.V. Miller R.R. Gorman Evidence for distinct prostaglandin 12 and D2 receptors in human platelets J Pharmacol Exp Ther 210 1979 134
108. D.C.B. Mills The role of cyclic nucleotides in platelets J.W Kebanian J.A Nathanson Handbook of Experimental Pharmacology. Berlin 58 1982 Springer-Verlag, Heidelberg 723 11
109. D.C.B. Mills W.R. Figures L.M. Scearce Two mechanisms for inhibition of ADP-induced platelet shape change by 5′-p′-fluorosulfonylbenzoyl adenosine: Conversion to adenosine an covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase J Biol Chem 260 1985 8078
110. D.C.B. Mills I.A. Robb G.C.K. Roberts The release of nucleotides, 5-hydroxytryp- tamine and enzymes from human blood platelets during aggregation J Physiol 193 1968 715
111. J.R.A. Mitchell A.A. Sharp Platelet clumping in vitro Br J Haematol 10 1964 78
112. L. Muszbek T. Kuznick T. Szabo Troponin C like protein of blood platelets FEBS Lett 80 1977 308
113. K.C. Nicolaou R.L. Magolda J.B. Smith Synthesis and biological properties of pinane thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation Proc Natl Acad Sei USA 70 1979 2566
114. H.K. Nieuwenhuis J.W.N. Akkerman W.P.N. Houdjik Human blood platelets showing no response to collagen fail to express surface glycoprotein la Nature 318 1986 470
115. Y. Nishizuka Y. Takai A. Kishimoto Phospholipid turnover in hormone action Recent Prog Horm Res 40 1984 301
116. D.H. Nugteren M. Buytenhek E. Crist-Hazelhof Enzymes involved in the conversion of endoperoxides Prog Lipid Res 20 1981 169
117. T.M.C. O’Halloran M.C. Beckerle K. Burridge Identification of talin as a major cytoplasmic protein implicated in platelet activation Nature 317 1985 449
118. 2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3 FEBS Lett 214 1987 176
119. 2+-transporting membrane vesicle fraction derived from human platelets J Biol Chem 260 1985 956
120. M.L. Ogletree D.N. Harris R. Greenberg Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist J Pharmacol Exp Ther 234: 1985 435
121. E. Pfeuffer R.H. Dreher H. Metzger Catalytic unit of adenylate cyclase: Purification and identification by cross-linking Proc Natl Acad Sei USA 82 1985 3086
122. C. Poll P. Kyrie J. Westwick Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation Biochem Biophys Res Commun 136 1986 381
123. 2 in thrombin-stimulated human platelets Biochim Biophys Acta 920 1987 205
124. R.N. Puri F. Zhou H. Bradford Thrombin-induced platelet aggregation in volves an indirect proteolytic cleavage of aggregm by calpain Arch Biochem Biophys 271 1989 346
125. M. Rand G. Ried Source of “serotonin” in serum Nature 168 1951 385
126. M.M. Rapport A.A. Green I.H. Page Serum vasoconstrictor (serotonin) IV. Isolation and characterization J Biol Chem 176 1948 1243
127. T.J. Rink T.J. Hallam What turns platelets on? Trends Biochem Sei 9 1984 215
128. 2+ thresholds and Ca- independent activation for shape change and secretion FEBS Lett 148 1982 21
129. S.E. Rittenhouse Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP Biochem J 222 1984 103
130. S.E. Rittenhouse J.P. Sasson Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester J Biol Chem 260 1985 8657
131. S. Rittenhouse-Simmons Production of diglyceride from phosphatidylinositol in activated human platelets J Clin Invest 63 1979 580
132. + + activated neutral proteases in platelets Experientia 38 1982 1099
133. S.A. Santoro Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent-cation dependent adhesion of platelets to collagen Cell 46 1986 913
134. A.I. Schafer B. Cooper D. O’Hara Identification of platelet receptors for prostaglandins 12 and D2 Biol Chem 254 1979 2914
135. K.B. Seamon J.W. Daly Forskolin, cyclic AMP and cellular physiology Trends Pharmacol Sei 4 1983 120
136. M.A. Selak M. Chignard J.B. Smith Cathepsin G is a strong platelet agonist released by neutrophils Biochem J 251 1988 293
137. 2+, indomethacin, CV-3988, and forskolin Arch Biochem Biophys 240 1985 674
138. 2 on human platelets Methods Enzymol 86 1982 179
139. A.M. Siegl J.W. Daly J.B. Smith Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin Mol Pharmacol 21 1982 680
140. 3H]prostacyclin on platelets J Clin Invest 63 1979 215
141. W. Siess M. Stifel H. Binder Activation of Vi-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets Biochem J 233 1986 83
142. 2+ mobilization in human platelets Nature 325 1987 456
143. + exchange in platelets activated with calcium-ionophore A 23187 Biochem Biophys Res Commun 125 1984 1123
144. 2+ mobilization start simultaneously in thrombin-stimulated platelets. Evidence that platelet shape change disturbs early rises of BCECF fluorescence which causes an underestimation of actual cytosolic alkalinization Biochem J 258 1989 521
145. M.D. Smigel Purification of the catalyst of adenylate cyclase J Biol Chem 261 1986 1976
146. J.B. Smith A.L. Willis Aspirin selectively inhibits prostaglandin production in human platelets Nature 231 1971 235
147. S.K. Smith L.E. Limbird Evidence that human platelet a-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylcyclase ADP-ribosylated by cholera toxin J Biol Chem 257 1982 10471
148. S. Supattapone P.F. Worley J.M. Baraben Solubilization, purification, and characterization of an inositol trisphosphate receptor J Biol Chem 263 1988 1530
149. J.D. Sweatt H.S. Banga R.K. Walker Pertussis toxin can activate human plate lets J Biol Chem 262 1987 14871
150. J. Takamatsu M.K. Home H.R. Gralnick Identification of the thrombin receptor on human platelets by chemical crosslinking J Clin Invest 77 1986 362
151. N.N. Tandon U. Kralisz G.A. Jamieson Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion J Biol Chem 264 1989 7576
152. A.P. Tarver W.G. King S.E. Rittenhouse Inositol 1,4,5-trisphosphate and inositol 1,2-cyclic 4,5-trisphosphate are minor components of total mass of inositol trisphosphate in thrombin-stimulated platelets. Rapid formation of inositol 1,3,4- trisphosphate J Biol Chem 262 1987 17268
153. 2 protein indistinguishable from lipocortin Nature 321 1986 177
154. J.P. Tranzer M. Da Prada A. Pletscher Ultrastructural localization of 5-hydroxytryp- tamine in blood platelets Nature 212 1966 1574
155. A.-L. Tsai M.-J. Hsu H. Vijjeswarapu Solubilization of prostacyclin membrane receptors from human platelets J Biol Chem 264 1989 61
156. T.B. Tschopp Aggregation of cat platelets in vitro Thromb Diath Haemorrh 23 1970 601
157. R.Y. Tsien New calcium indicators and buffers with high selectivity against magnesium and protons: Design and properties of prototype structures Biochemistry 19 1980 2396
158. R.Y. Tsien T. Pozzan T.J. Rink Calcium homeostasis in intact lymphocytes: Cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator J Cell Biol 94 1982 325
159. A.G.G. Turpie J. Hirsh Platelet suppressive therapy Br Med Bull 34 1978 183
160. A.J.M. Verhoeven O.-B. Tynes G.M. Aarbakke Turnover of the phospho- monoester groups of polyphosphoinositol lipids in unstimulated human platelets Eur J Biochem 166 1987 3
161. J.D. Vickers R.L. Kinlough-Rathbone J.F. Mustard Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium Biochem J 224 1984 399
162. S.A. Waldman F. Murad Cyclic GMP synthesis and function Pharmacol Rev 39 1987 163
163. L.-L. Wang J. Bryan Isolation of calcium-dependent platelet proteins that interact with actin Cell 25 1981 637
164. S.P. Watson R.T. McConnell E.G. Lapetina The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin J Biol Chem 259 1984 13199
165. H.J. Weiss V.T. Turitto H.R. Baumgartner Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear dependent decrease of adhesion in von Willebrand’s disease and Bernard Soulier syndrome J Lab Clin Med 92 1978 750
166. 2 Biochem Biophys Res Commun 90 1980 473
167. J. Yamanishi Y. Takai K. Kaibuchi Synergistic functions of phorbol ester and calcium in serotonin release from human platelets Biochem Biophys Res Commun 112 1983 778
168. K. Yoshida V.T. Nachmias Phorbol ester stimulates calcium sequestration in saponized human platelets J Biol Chem 262 1987 16048
169. + exchange and its inhibition by amiloride analogs J Biol Chem 261 1986 13160
170. M.B. Zucker W. Troll S. Belman The tumor-promoter (12-O-tetradecanoyl-phorbol- 13-acetate), a potent aggregating agent for blood platelets J Cell Biol 60 1974 325