Acute‐phase response of human hepatocytes: Regulation of acute‐phase protein synthesis by interleukin‐6

Hepatology

Volumn 12, Issue 5, 1990, Pages 1179-1186

  Castell, José V ^a   Gómez‐lechón, Maria José ^b   David, Martina ^a   Fabra, Ricardo ^c   Trullenque, Ramón ^c   Heinrich, Peter C ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 6;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ALPHA 1-ANTITRYPSIN; C-REACTIVE PROTEIN; DEXAMETHASONE; FIBRINOGEN; HUMAN; INTERLEUKIN-1; INTERLEUKIN-6; LIVER; RNA, MESSENGER; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T; TUMOR NECROSIS FACTOR;

EID: 0025228036     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.1840120517     Document Type: Article

References (57)

1. The phenomenon of the acute phase response
2. Effect of extracts from rabbit leukocytes on levels of acute phase globulins in rat serum
3. The effect of leukocytic endogenous mediator (LEM)
4. Monokine‐induced synthesis of serum amyloid A
5. A regulatory pathway for fibrinogen biosynthesis involving an indirect feedback loop
6. Infection, inflammation and interleukin‐1
7. Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat and mouse
8. Monocyte‐conditioned medium, interleukin‐1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro
9. Cachetin/tumor necrosis factor regulates hepatic acute‐phase gene expression
10. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin‐1 (II‐1) and purified human Il‐1
11. Induction of 26‐kDa‐protein mRNA in human cells treated with an interleukin‐1‐related, leukocyte‐derived factor
12. Interleukin 1 and poly(rI) poly(rC) induce production of a hybridoma growth factor by human fibroblasts
13. Production of B cell stimulatory factor‐2/interleukin‐6 activity by human endothelial cells
14. Interleukin‐6: structure, production and actions
15. Induction of rat acute‐phase proteins by interleukin‐6 in vivo
16. Interferon β2/BSF‐2 shares identity with monocyte derived hepatocyte stimulating factor (HSF) and regulates the major acute phase protein response in liver cells
17. Recombinant human B cell stimulatory factor‐2 (BSF2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells
18. Regulation of synthesis and secretion of major rat acute‐phase proteins by recombinant human interleukin‐6 (BSF‐2/IL‐6) in hepatocyte primary cultures
19. Action of recombinant human interleukin‐6, interleukin‐1β and tumor necrosis factor α on the mRNA induction of acute‐phase proteins
20. Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte—stimulating factors and monokines in rat hepatoma cells
21. Role of interleukin‐6 regulating synthesis of C‐reactive protein and serum amyloid A in human hepatoma cell lines
22. Interleukin 6, the third mediator of acute phase reaction, modulates hepatic protein synthesis in human and mouse: comparison with interleukin‐1β and tumor necrosis factor α
23. Recombinant human interleukin‐6 (IL‐6/BSF‐2 HSF) regulated the synthesis of acute phase proteins in human hepatocytes
24. Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
25. Human hepatocyte cultures
26. Human hepatocytes in primary monolayer cultures: maintenance of mixed function oxidase and conjugation pathway of drug metabolism
27. Glutathione levels in human hepatocytes exposed to paracetamol: efficacy of sulfhydryl derivatives in preventing paracetamol‐induced glutathione depletion
28. Complementary DNA for a novel human interleukin (BSF‐2) that induces B lymphocytes to produce immunoglobulin
29. Mononuclear phagocytes (Kupffer cells) and endothelial cells: indentification of two functional cell types in rat liver sinusoids by endogenous peroxidase activity
30. Culture of human hepatocytes from small surgical biopsies: biochemical characterization and comparison with in vivo
31. Induction of α1‐acid glycoprotein by recombinant human interleukin‐1 in rat hepatoma cells
32. Cytoplasmic dot hybridization
33. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
34. Induction of acute‐phase proteins by dexamethasone in rat hepatocyte primary cultures
35. 1‐acid glycoprotein and other acute phase reactants in rat liver and hepatoma cells
36. 2‐globulin
37. Influence of the adrenal glucocorticoids on the stimulation of synthesis of hepatic ribonucleic acid and plasma acute phase globulins by leucocytic‐endogenous mediator
38. Biosynthesis of human C‐reactive protein in cultured hepatoma cells is induced by a monocyte factor(s) other than interleukin‐1
39. Interaction among hepatocyte‐stimulating factors, interleukin‐1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells
40. The effect of interleukin‐1, interleukin‐6 and its interrelationship on the synthesis of serum amyloid A and C‐reactive protein in primary cultures of adult human hepatocytes
41. Hepatocyte‐stimulating factor III shares structural and functional identity with leukemia‐inhibitory factor
42. 1 regulates production of acute phase proteins
43. Epidermal growth factor and transforming growth factor‐β differently modulate the acute phase response elicited by interleukin‐6 in cultured liver cells from man, rat and mouse
44. Interleukin‐6: the major regulator of acute phase protein synthesis in man and rat
45. Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte stimulating factor in the rat
46. Fate of IL‐6 in the rat: involvement of skin in its catabolism
47. Fate and biological action of human recombinant interleukin‐1β in the rat in vivo
48. IL‐6/IFN‐β‐2 as a circulating hormone: induction by cytokine administration in humans
49. Regulation of the acute phase and immune responses in viral disease
50. Bacterial lipopolysaccharide and inflammatory mediators augment IL‐6 secretion by human endothelial cells
51. Interleukin‐6 and the acute phase response
52. Elevated levels of the 26K human hybridoma growth factor (interleukin‐6) in cerebrospinal fluid of patients with acute infection of the central nervous system
53. Interleukin‐6(IL‐6)in serum and urine of renal transplant recipients
54. Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
55. Production of B cell stimulatory factor‐2 and interferon‐γ in the central nervous system during viral meningitis and encephalitis