Effects of 12-Sulfodehydroabietic Acid Monosodium Salt (TA-2711),a New Anti-Ulcer Agent on Gastric Mucosal Lesions Induced by Necrotizing Agents and Gastric Mucosal Defensive Factors in Rats

the japanese journal of pharmacology

Volumn 52, Issue 4, 1990, Pages 631-638

  Onoda, Yuichi ^a   Takido, Mine ^a   Magaribuchi, Tetsuo ^a   Tamaki, Hajime ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

12 SULFODEHYDROABIETIC ACID; 16,16 DIMETHYLPROSTAGLANDIN E2; ALCOHOL; BICARBONATE; CETRAXATE; DODECYL SULFATE SODIUM; HYDROCHLORIC ACID; INDOMETACIN; PROSTAGLANDIN E2; SODIUM HYDROXIDE; SUCRALFATE;

ANIMAL EXPERIMENT; ARTICLE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH POTENTIAL; STOMACH PROTECTION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTI-ULCER AGENTS; DINOPROSTONE; DITERPENES; DITERPENES, ABIETANE; GASTRIC ACID; GASTRIC MUCOSA; MALE; MEMBRANE POTENTIALS; MUCUS; RATS; RATS, INBRED STRAINS; REGIONAL BLOOD FLOW; STOMACH ULCER; SUCRALFATE; TRANEXAMIC ACID;

EID: 0025217917     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.52.631     Document Type: Article

References (24)

1. Onoda, Y., Magaribuchi, T. and Tamaki, H.: Effects of 12-sulfodehydroabietic acid mono-sodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers in rats. Japan. J. Pharmacol. 51, 65-73 (1989)
2. Miller, T.A.: Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanism. Am. J. Physiol. 245, G601-G623 (1983)
3. Robert, A., Nezamis, J., Lancaster, C. and Hanchar, A.J.: Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77, 433-443 (1979)
4. Arakawa, T., Kobayashi, K., Nakamura, H., Chono, S., Yamada, H., Ono, T. and Yamamoto, S.: Effect of water-immersion stress on prostaglandin E2 in rat gastric mucosa. Gastroenterol. Japon. 16, 236-241 (1981)
5. Tarnawski, A. and Ivey, K.J.: Transmucosal potential difference profile in rat upper gastrointestinal tract. A simple model for testing gastric effects of pharmacologic agents. Can. J. Physiol. Pharmacol. 56, 471-473 (1978)
6. Saita, H., Murakami, M., Ashida, Y., Hozu, S. and Miyake, T.: Factors affecting gastric mucosal blood flow measurement in rats. Japan. Arch. Int. Med. 33, 21-31 (1986)
7. Corne, S.J. and Woods, R.J.: A method of quantitative estimation of gastric barrier mucus. J. Physiol. (Lond.) 242, 116P-117P (1974)
8. Garner, A. and Flemstrdm, G.: Gastric HCO3-secretion in the guinea pig. Am. J. Physiol. 234, E535-E541 (1978)
9. Kurebayashi, Y., Ikeda, T. and Osada, Y.: Cytoprotective action of cetraxate against HCl ethanol-induced gastric lesion in rats, Japan. J. Pharmacol. 46, 17-25 (1988)
10. Hollander, D., Tarnawski, A., Krause, W.J. and Gergely, H.: Protective effect of sucralfate against alcohol-induced gastric mucosal injury in rats. Gastroenterology 88, 366-374 (1985)
11. Robert, A., Nezamis, J.E., Lancaster, C., Davis, J.P., Field, S.O. and Hanchar, A.J.: Mild irritants prevent gastric necrosis through “adaptive cytoprotection” mediated by prostaglandins. Am. J. Physiol. 245, G113-G121 (1983)
12. Konturek, S.J., Brozozowski, T., Piastucki, T., Radecki, T., Dembinski, A. and Dembinska-Kiec, A.: Role of locally generated prostaglandins in adaptive gastric cytoprotection. Dig. Dis. Sci. 27, 967-971 (1982)
13. Nobuhara, Y. and Takeuchi, K.: Possible role of endogenous prostaglandins in alkaline response in rat gastric mucosa damaged by hypertonic NaCl. Dig. Dis, Sci. 29, 1142-1147 (1984)
14. Takeuchi, K., Yamakuni, H., Nobuhara, Y. and Okabe, S.: Functional and morphological alterations in the rat stomach following exposure to hypertonic NaCl solution. Japan. J. Pharmacol. 42, 549-560 (1986)
15. Takeuchi, K., Ueki, S. and Tanaka, H.: Endogenous prostaglandins in gastric alkaline response in the rat stomach after damage. Am. J. Physiol. 250, G842-G849 (1986)
16. Takeuchi, K., Nishiwaki, H., Furukawa, O. and Okabe, S.: Cytoprotective action of histamine against 0.6 N HCl-induced gastric mucosal injury in rats; comparative study with adaptive cytoprotection induced by exogenous acid. Japan. J. Pharmacol. 44, 335-344 (1987)
17. Ohno, T., Nakagawa, M., Nishimura, S., Takeuchi, K. and Okabe, S.: Effect of 16,16-dimethyl prostaglandin E2 on gastric surface epithelial cell damage induced by 20% ethanol in rats. Japan. J. Pharmacol. 45, 327-334 (1987)
18. Oates, P.J. and Hakkinen, J.P.: Studies on the mechanisms of ethanol-induced gastric damage in rats. Gastroenterology 94, 10-21 (1988)
19. Leung, F.W., Robert, A. and Guth, P.H.: Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. Gastroenterology 88, 1948-1953 (1985)
20. Yoney, Y. and Guth, P.H.: Laparotomy stimulates an endogenous gastric mucosal protective mechanism in the rat. A microcirculatory and morphologic study of ethanol injury. Gastroenterology 95, 600-611 (1988)
21. Piham, G., Majzoubi, D., Haudenschrld, C., Trier, J.S. and Szabo, S.: Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 91,1415-1426 (1986)
22. Suzuki, Y., Ito, M. and Sudo, Y.: Studies on the mechanism of action of cetraxate (4'-(2-carboxyethyl)phenyl trans-4-aminoethyl cyclo-hexanecarboxylate hydrochloride), a new antiulcer agent. Japan. J. Pharmacol. 29, 829-838 (1979)
23. Pearson, J., Allen, A. and Vernables, C.: Gastric mucus: Isolation and polymeric structure of the undegraded glycoprotein: Its breakdown by pepsin. Gastroenterology 78, 709-715 (1980)
24. Allen, A. and Garner, A.: Gastric mucus and bicarbonate secretion and their possible role in mucosal protection. Gut 21, 249-262 (1980)