A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

Toxicology and Applied Pharmacology

Volumn 103, Issue 3, 1990, Pages 399-410

  Leung, Hon Wing ^a   Paustenbach, Dennis J ^b   Jay Murray, F ^a   Andersen, Melvin E ^c  

^a ROCHE BIOSCIENCE   (United States)

^b CARDNO CHEMRISK   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARTMENT MODEL; ENZYME INDUCTION; LIVER MICROSOME; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SIMULATION; TISSUE DISTRIBUTION;

ANIMAL; ARYL HYDROCARBON HYDROXYLASES; COMPARATIVE STUDY; CYTOSOL; DIOXINS; DRUG ADMINISTRATION SCHEDULE; ENZYME INDUCTION; FEMALE; LIVER; MODELS, BIOLOGICAL; PROTEIN BINDING; RATS; RATS, INBRED STRAINS; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, DRUG; TETRACHLORODIBENZODIOXIN; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0025212601     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(90)90313-J     Document Type: Article

References (34)

1. Application of DACSL (Dow Advanced Continuous Simulation Language) to the design and analysis of chemical reactors
2. 14C]tetrachlorodibenzo-p-dioxin in rats
3. Tissue dosimetry in risk assessments, or what's the problem here anyway?
4. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat
5. A multiple dose-route physiological pharmacokinetic model for volatile chemicals using ACSL/PC
6. Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J and B6D2F1/J mice
7. Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species
8. Genetic regulation of aryl hydrocarbon hydroxylation induction
9. Effects of TCDD on drug metabolism and hepatic microsomes in rats and mice
10. A physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species
11. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats
12. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
13. A physiologically-based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice
14. 125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach
15. Dioxin in soil: Bioavailability after ingestion by rats and guinea pigs
16. The multistage theory of carcinogenesis and the age distribution of cancer in man
17. Mutation and cancer: A model for human carcinogenesis
18. Two event models for carcinogenesis: Incidence curves for childhood and adult tumors
19. The toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mammalian systems
20. Tissue distribution and excretion of octachlorodibenzo-p-dioxin in the rat
21. Stereospecific high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol
22. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons; examination of the mechanism of toxicity
23. Studies on the mechanism of action of halogenated aromatic hydrocarbons
24. 125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin binding species in mouse liver induced by agonists for the Ah receptor: Characterization and identification
25. 125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonists for the Ah receptor
26. A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans
27. The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat
28. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
29. Toxicology of chlorinated dibenzo-p-dioxins
30. Dioxins and the Ah receptor
31. The Hepatic Uptake of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Mouse
32. Use of a physiological compartmental model for the rat to describe the pharmacokinetics of several chlorinated biphenyls in the mouse
33. Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity