Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective ligands

British Journal of Pharmacology

Volumn 101, Issue 3, 1990, Pages 621-624

  Hew, R W S ^a   Hodgkinson, C R ^a   Hill, S J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (4 IMIDAZOLYL)PROPYL] 3 METHYLTHIOUREA; ALPHA METHYLHISTAMINE; ANTIHISTAMINIC AGENT; ATROPINE; BURIMAMIDE; CARBACHOL; HISTAMINE H3 RECEPTOR; IMPROMIDINE; MEPYRAMINE; NORBURIMAMIDE; PENTOLONIUM TARTRATE; SKF 91486; THIOPERAMIDE; TIOTIDINE; UNCLASSIFIED DRUG; GUANIDINE DERIVATIVE; HISTAMINE DERIVATIVE; HISTAMINE RECEPTOR; IMIDAZOLE DERIVATIVE; PIPERIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHOLINERGIC TRANSMISSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; ELECTROSTIMULATION; FEMALE; GUINEA PIG; ILEUM; MALE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; ANIMAL; DRUG EFFECT; IN VITRO STUDY; METABOLISM; MUSCLE CONTRACTION; SMOOTH MUSCLE;

ANIMAL; ELECTRIC STIMULATION; FEMALE; GUANIDINES; GUINEA PIGS; ILEUM; IMIDAZOLES; IMPROMIDINE; IN VITRO; MALE; METHYLHISTAMINES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PENTOLINIUM TARTRATE; PIPERIDINES; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3;

EID: 0025197293     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1990.tb14130.x     Document Type: Article

References (19)

1. AMBACHE, N., KILLICK, S.W. & ZAR, ABOO M. (1973). Antagonism by burimamide of inhibitions induced by histamine in plexus‐containing longitudinal muscle preparations from guinea‐pig ileum. Br. J. Pharmacol., 48, 362–363P.
2. ARRANG, J.M., GARBARG, M. & SCHWARTZ, J.C. (1983). Auto‐inhibition of brain histamine release mediated by a novel class (H 3) of histamine receptor. Nature, 302, 832–837.
3. ARRANG, J.M., GARBARG, M. & SCHWARTZ, J.C. (1985). Autoregulation of histamine release in brain by presynaptic H 3 ‐receptors. Neuroscience, 15, 553–562.
4. ARRANG, J.M., GARBARG, M., LANCELOT, J.C., LECOMPTE, J.M., POLLARD, H., ROBBA, M., SCHUNACK, W. & SCHWARTZ, J.C. (1987). Highly potent and selective lingands for histamine H 3 ‐receptors. Nature, 327, 117–123.
5. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 153–161.
6. ASH, A.S.F. & SCHILD, H.O. (1966). Receptors mediating some actions of histamine. Br. J. Pharmacol. Chemother., 27, 427–439.
7. BARKER, L.A. & HOUGH, L.B. (1983). Selectivity of 4‐methylhistamine at H 1 ‐ and H 2 ‐receptors in the guinea‐pig isolated ileum. Br. J. Pharmacol., 80, 65–71.
8. BARNES, P.J. & ICHINOSE, M. (1989). H 3 in airways. Trends Pharmacol. Sci., 10, 264.
9. BLAIR‐WEST, J.R., HARDING, R. & McKENZIE, J.S. (1967). The action of angiotensin II on guinea‐pig ileum and its modification by changes in sodium concentration. Br. J. Pharmacol. Chemother., 31, 229–243.
10. FJALLAND, B. (1979). Evidence for the existence of another type of histamine H 2 ‐receptor in guinea‐pig ileum. J. Pharm. Pharmacol., 31, 50–51.
11. GANELLIN, C.R. (1982). Chemistry and structure‐activity relationships of drugs acting at histamine‐receptors. In Pharmacology of Histamine Receptors ed. Ganellin, C.R. & Parsons, M.E. pp. 10–102. Bristol: Wright.
12. HILL, S.J. (1987). Histamine receptors branch out. Nature, 327, 104–105.
13. HILL, S.J. (1990). Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol. Rev., (in press).
14. HILL, S.J. & YOUNG, J.M. (1981). Characterization of 3 H‐mepyramine binding to the longitudinal muscle of guinea‐pig small intestine. Mol. Pharmacol., 19, 379–387.
15. ICHINOSE, M. & BARNES, P.J. (1989). Inhibitory histamine H 3 ‐receptors on cholinergic nerves in human airways. Eur. J. Pharmacol., 97, 13–15.
16. ICHINOSE, M., STRETTON, C.D., SCHWARTZ, J.C. & BARNES, P.J. (1989). Histamine H 3 ‐receptors inhibit cholinergic neurotransmission in guinea‐pig airways. Br. J. Pharmacol., 97, 13–15.
17. RANG, H.P. (1964). Stimulant actions of volatile anaesthetics on smooth muscle. Br. J. Pharmacol. Chemother., 22, 356–365.
18. TAMURA, K., PALMER, J. & WOOD, J.D. (1988). Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience, 25, 171–179.
19. TRZECIAKOWSKI, J.P. (1987). Inhibition of guinea‐pig ileum contractions mediated by a class of histamine receptors resembling the H 3 ‐subtype. J. Pharmacol. Exp. Ther., 243, 874–880.