High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

Biochemical Pharmacology

Volumn 39, Issue 3, 1990, Pages 489-498

  Sesardic, Dorothea ^a   Edwards, Robert J ^a   Davies, Donald S ^a   Thomas, Paul E ^b   Levin, Wayne ^b   Boobis, Alan R ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b HOFFMANN LA ROCHE INC   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; ISOSAFROLE; MONOCLONAL ANTIBODY; PHENACETIN; PHENOBARBITAL; POLYCLONAL ANTIBODY; CYCLOHEXANE DERIVATIVE; CYTOCHROME P 450 CYP1A2; CYTOCHROME P 450 ENZYME SYSTEM; CYTOCHROME P450; CYTOCHROME P450 1A2; ISOENZYME; OXIDOREDUCTASE; SAFROLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; IMMUNOLOGY; KINETICS; METABOLISM; MOLECULAR WEIGHT; RAT STRAIN; WESTERN BLOTTING;

ANIMAL; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CYCLOHEXANES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ISOENZYMES; KINETICS; MALE; METHYLCHOLANTHRENE; MICROSOMES, LIVER; MOLECULAR WEIGHT; OXIDOREDUCTASES; PHENACETIN; RATS; RATS, INBRED STRAINS; SAFROLE; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0025194581     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(90)90055-P     Document Type: Article

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