Role of Ca2+-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2+-ATPase inhibitor, thapsigargin

Agents and Actions

Volumn 29, Issue 1-2, 1990, Pages 8-15

  Thastrup, O ^a,b  

^a Rigshospitalet   (Denmark)

^b Copenhagen Science Park Symbion ^*  (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; THAPSIGARGIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); CA(2+) TRANSPORTING ATPASE; TERPENE;

CELL; CELL CULTURE; CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; ENZYMOLOGY; MICROSOME; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; CA(2+)-TRANSPORTING ATPASE; CALCIUM; HUMAN; MICROSOMES; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TERPENES; THAPSIGARGIN;

EID: 0025193998     PISSN: 00654299     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/BF01964706     Document Type: Article

References (59)

1. Intracellular calcium homeostasis
2. Ca2+-transport ATPases in the plasma membrane and endoplasmic reticulum
3. The transport of calcium across the inner membrane of mitochondria
4. Electrophoretic separation of different phosphoproteins associated with Ca-ATPase and Na, K-ATPase in human red cell ghosts
5. The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification
6. Cyclic GMP regulation of the plasma membrane Ca-Mg ATPase in vascular smooth muscle
7. The calcium pump of erythrocytes and other animal cells
8. Complete primary structure of a human plasma membrane calcium pump
9. Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum.
10. The phosphorylation of the membranal protein of the sarcoplasmic vesicles during active calcium transport
11. Kinetics of calcium transport by fragmented sarcoplasmic reticulum
12. Two Ca2+ ATP genes: homologies and mechanistic implications of deduced amino acid sequence
13. Structure of the rabbit fast twich skeletal muscle Ca2+-ATPase gene
14. Topology of the erythrocyte Ca2+ pump. A monoclonal antibody against the almost inaccessible extracellular face
15. Effects of affinity-purified antibodies on the Ca2+ pumping ATPase of erythrocyte membranes
16. Amino-acid sequence of a Ca2++Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence
17. Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene
18. Thapsigargin and thapsigargicin, two new histamine liberators from thapsia garganica
19. A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells
20. Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis
21. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage
22. Activation of calcium entry by the tumor promoter, thapsigargin, in parotid acinar cells. Evidence that an intracellular calcium pool, and not an inositol phosphate, regulates calcium fluxes at the plasma membrane
23. Thrombin-induced calcium movements in platelet activation
24. Effects of the Ca2+-mobilizing tumour promoter thapsigargin and an inositol trisphosphate mobilizing agonist on cystosolic Ca2+ in bovine adrenal chromaffin cells
25. Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation, by bradykinin receptors on pig articular chondrocytes
26. Micro-injection of inositol(1,3,4,5) tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+
27. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration
28. Inositol phosphates: proliferation, metabolism and function
29. A model for receptor-regulated calcium entry
30. Control of calcium channels by membrane receptors in the rat parotid gland
31. Agonists stimulate divalent cation channels in the plasma membrane of human platelets
32. The calcium mobilizing and tumour promoting agent, thapsigargin, elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumour promotion
33. The inflammatory and tumor-promoting sesquiterpene lactone thapsigargin activates platelets by selective mobilization of calcium as shown by protein phosphorylation
34. Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDS
35. Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages
36. Thapsigargin, a new calcium dependent epithelial anion secretagogue
37. Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+−Mg2+) ATPase
38. Partial purification of the Ca2+−Mg2+-ATPase activator from human erythrocytes: its similarity to the activator of 3′: 5′-cyclic nucleotide phosphodiesterase
39. Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+-ATPase
40. Phosphorylation of the Ca2+-pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinase
41. Regulation of Ca2+-pumping ATPase of heart sarcolemma by a phosphorylation-dephosphorylation process
42. Cyclic GMP regulation of the plasma membrane Ca−Mg ATPase in vascular smooth muscle
43. Effects of cyclic AMP-dependent and cyclic-GMP-dependent protein kinases. and calmodulin on calcium uptake by highly purified sarcolemmal vesicles of vascular smooth muscle
44. Studies on the mechanism of thyroid hormone stimulation in vitro of human red cell Ca2+-ATPase activity
45. Guanine nucleotide-, and inositol trisphosphate-induced inhibition of the Ca2+ pump in rat sarcolemmal vesicles
46. Inositol trisphosphate and the contraction of vascular smooth muscle cells
47. Carbachol partially inhibits the plasma-membrane Ca2+-pump in microsomes from pig stomach smooth muscle
48. ATP-dependent calcium transport in rat parotid basolateral membrane vesicles in modulated by membrane potential
49. Vasopressin-, angiotensin II-, and α1 inhibition of Ca2+ transport by rat liver plasma membrane vesicles
50. Inhibition by glucagon of the calcium pump in liver plasma membranes
51. Phosphorylation of the sarcoplasmic reticulum and sarcolemma
52. Effects of adenosine 3′: 5′-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal muscles
53. Ca2+-transport ATPases of vascular smooth muscle
54. Evidence for the presence of phospholamban in the endoplasmic reticulum of smooth muscle