Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro

Neuroscience Letters

Volumn 110, Issue 1-2, 1990, Pages 52-59

  Dray, A ^a   Forbes, C A ^a   Burgess, G M ^a  

^a Sandoz Institute for Medical Research   (United Kingdom)

Author keywords

Calcium blocker; Capsaicin; Fura 2; Membrane current; Nociceptor; Ruthenium red; Single channel

Indexed keywords

CALCIUM CHANNEL; CAPSAICIN; RUTHENIUM RED;

ANIMAL EXPERIMENT; ARTICLE; NEWBORN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; BENZOFURANS; CALCIUM; CAPSAICIN; FLUORESCENT DYES; FURA-2; GANGLIA, SPINAL; NEURONS, AFFERENT; NOCICEPTORS; PERIPHERAL NERVES; RATS; RUTHENIUM; RUTHENIUM RED;

EID: 0025191123     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(90)90786-9     Document Type: Article

References (24)

1. Ruthenium red selectively inhibits capsaicin-induced release of calcitonin gene-related peptide from the isolated perfused guinea pig lung
2. Ruthenium red selectively prevents capsaicin-induced nociceptor stimulation
3. Some rat sensory neurons in culture express characteristics of differentiated pain sensory neurons
4. Calcium buffering in axons and axoplasm of Loligo
5. Calcium and the effects of capsaicin on afferent fibres in a neonatal rat isolated spinal cord-tail preparation
6. Membrane effects of capsaicin on dorsal root ganglion neurons in cell culture
7. The mechanism of action of capsaicin a sensory neurotoxin
8. The neuropharmacology of capsaicin: review of some recent observations
9. Properties of single capsaicin-activated channels
10. Uptake and release of calcium by rat brain synaptosomes
11. 2+ indicators with greatly improved fluorescent properties
12. Depolarizing responses to capsaicin in a subpopulation of rat dorsal root ganglion cells
13. Local effector function of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
14. The sensory-efferent function of capsaicin-sensitive sensory neurons
15. Protective action of ruthenium red toward capsaicin desensitization of sensory fibres
16. The antagonism induced by ruthenium red of the actions of capsaicin on the peripheral terminals of sensory neurons: further studies
17. The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro
18. 2+ transport by ruthenium red
19. Local anaesthetics transiently block currents through single acetylcholine-receptor channels
20. Mitochondrial calcium transport
21. The inhibition of mitochondrial calcium transport by lanthanides and ruthenium red
22. Uptake of calcium by synaptosomes from rat brain
23. 2+ pump
24. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture