Synthesis of Peptidyl Fluoromethyl Ketones and Peptidyl α-Keto Esters as Inhibitors of Porcine Pancreatic Elastase, Human Neutrophil Elastase, and Rat and Human Neutrophil Cathepsin G

Journal of Medicinal Chemistry

Volumn 33, Issue 1, 1990, Pages 394-407

  Peet, Norton P ^a,b   Burkhart, Joseph P ^a,b   Angelastro, Michael R ^a,b   Giroux, Eugene L ^a,b   Mehdi, Shujaath ^a,b   Bey, Philippe ^a,b   Kolb, Michael ^a,b   Neises, Bernhard ^a,b   Schirlin, Daniel ^a,b  

^a Merrell Dow Research Institute   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; ELASTASE; N1 [NALPHA (ADAMANTYLSULFONYL) NEPSILON (4 METHOXY 1,4 DIOXOBUTYL)LYSYL] NALPHA (3,3,3 TRIFLUORO 1 ISOPROPYL 2 OXOPROPYL)PROLINAMIDE; PEPTIDE FLUOROMETHYL KETONE; PEPTIDYL ALPHA KETO ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMAL; CATHEPSINS; CHEMISTRY; COMPARATIVE STUDY; HUMAN; KETONES; KINETICS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NEUTROPHILS; OLIGOPEPTIDES; PANCREAS; PANCREATIC ELASTASE; PROTEASE INHIBITORS; RATS; STEREOISOMERISM; SWINE;

EID: 0025176920     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00163a063     Document Type: Article

References (7)

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