Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐l‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin: X‐ray crystallographic determination of the NAPAP‐trypsin complex and modeling of NAPAP‐thrombin and MQPA‐thrombin

European Journal of Biochemistry

Volumn 193, Issue 1, 1990, Pages 175-182

  BODE, Wolfram ^a   TURK, Dušan ^a   STÜRZEBECHER, Jörg ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b Medizinische Hochschule Erfurt   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN; THROMBIN INHIBITOR;

ARTICLE; HUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIMAL; ANTITHROMBINS; BINDING SITES; CATTLE; COMPUTER GRAPHICS; CRYSTALLOGRAPHY; HUMAN; IN VITRO; MODELS, MOLECULAR; MODELS, STRUCTURAL; MOLECULAR CONFORMATION; PIPECOLIC ACIDS; PIPERIDINES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; THROMBIN; TRYPSIN; TRYPSIN INHIBITORS; X-RAY DIFFRACTION;

EID: 0025175641     PISSN: 00142956     EISSN: 14321033     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1990.tb19320.x     Document Type: Article

References (40)

1. Crystal orientation and X-ray pattern prediction routines for area-detector diffractometer systems in macromolecular crystallography
2. A graphics model building and refinement system for macromolecules
3. The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
4. The accuracy of electron-density maps in X-ray analysis with special reference to dibenzyl