Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels

European Journal of Pharmacology

Volumn 176, Issue 1, 1990, Pages 97-101

  Chan, Susan L F ^a   Morgan, Noel G ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Efaroxan; Imidazoline receptors; Insulin secretion; Islets of Langerhans; 2 Andrenoceptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; DIAZOXIDE; EFAROXAN; GLUCOSE; IDAZOXAN; NORADRENALIN; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; DRUG CONCENTRATION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

ANIMAL; BENZOFURANS; DIAZOXIDE; GLUCOSE; HYPOGLYCEMIC AGENTS; IMIDAZOLES; IN VITRO; INSULIN; ISLETS OF LANGERHANS; MALE; POTASSIUM CHANNELS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0025173880     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(90)90137-U     Document Type: Article

References (10)

1. 2-adrenoceptor antagonist, on insulin release in conscious rats
2. Effects of α-antagonists on insulin secretion from rat pancreatic islets
3. α-Adrenoceptor reagents. 2. Effects of modification of the 1,4 benzodioxan ring system on α-adrenoceptor activity
4. Evidence for imidazoline binding sites in basolateral membranes from rabbit kidney
5. Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli
6. 2-adrenoceptors in rabbit adipocyte membranes
7. + channel opener, cromakalim
8. 2-adrenergic drugs also bind with high affinity to a nonadrenergic site
9. Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans
10. Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release