Saintopin, a new antitumor antibiotic with topoisomerase ii dependent dna cleavage activity, from paecilomyces

Journal of Antibiotics

Volumn 43, Issue 10, 1990, Pages 1344-1346

  Yamashita, Yoshinori ^a   Saitoh, Yutaka ^a   Ando, Katsuhiko ^a   Takahashi, Keiichi ^a   Ohno, Hlroe ^a   Nakano, Hlrofumi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; SAINTOPIN; UNCLASSIFIED DRUG;

CELL CULTURE; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SCREENING; ENZYME ACTIVITY; FUNGUS; GRAM POSITIVE BACTERIUM; LETTER; NONHUMAN; PRIORITY JOURNAL;

EID: 0025165637     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.43.1344     Document Type: Article

References (6)

1. WANG, J. C.: DNA topoisomerases. Annu. Rev. Biochem. 54: 665-695, 1985
2. LIU, L. F.: DNA topoisomerase poisons as antitumor agents. Annu. Rev. Biochem. 58: 351-375, 1989
3. D'ARPA, P. & L. F. LIU: Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 989: 163-177, 1989
4. YAMATO, M.; Y. TAKEUCHI, K. HASHIGAKI, Y. IKEDA, C. MING-RONG, K. TAKEUCHI, M. MATSUSIMA, T. TSURUO, T. TASHIRO, S. TSUKAGOSHI, Y. YAMASHITA & H. NAKANO: Synthesis and antitumor activity of fused tetracyclic quinone derivatives. 1. J. Med. Chem. 32: 1295-1300, 1989
5. YAMASHITA, Y.; S. KAWADA & H. NAKANO: Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol. Biochem. Pharmacol. 39:737-744,1990
6. SAITOH, Y.; Y. YAMASHITA & H. SANO: Structure of saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity. J. Antibiotics, in preparation