Retinal accumulation of the phosducin/Tβγ and transducin complexes in developing normal mice and in mice and dogs with inherited retinal degeneration

Experimental Eye Research

Volumn 51, Issue 3, 1990, Pages 325-333

  Lee, Rehwa H ^a   Lieberman, Bernice S ^b   Lolley, Richard N ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

phosducin T ; photoreceptor; retina; retinal degeneration; transducin

Indexed keywords

PHOSPHOPROTEIN; TRANSDUCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOG; HEREDITY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DYSTROPHY;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; EYE PROTEINS; MACROMOLECULAR SYSTEMS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHOSPHOPROTEINS; REFERENCE VALUES; RETINA; RETINAL DEGENERATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSDUCIN;

EID: 0025161420     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-4835(90)90029-T     Document Type: Article

References (34)

1. Abnormal rod renewal in early retinal degeneration
2. Control of rod outer segment renewal is aberrant in early retinal degeneration
3. Retinal degeneration in the dogs. I. Rod dysplasia
4. Retinal degenerations in the dog III abnormal cyclic nucleotide metabolism in rod-cone dysplasia
5. Rod-cone dysplasia in Irish setters: a defect in cyclic GMP metabolism in visual cells
6. Opsin G-Protein and 48-kDa protein in normal rd mouse retinas developmental expression of mRNAs and proteins and light/dark cycling of mRNAs
7. i signal-transducing proteins and those of bovine retinal rod cell transducin are identical
8. Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina
9. Characterization of transducin from bovine retinal rod outer segments
10. Flow of information in the light-triggered cyclic nucleotide cascade of vision
11. i
12. G proteins and dual control of adenylate cyclase
13. Interaction of rod cell proteins with the disk membrane: influence of light, ionic strength, and nucleotides
14. Cleavage of structural proteins during the assembly of the head of bacteriophage
15. Retinal degeneration in mouse
16. Light-induced dephosphorylation of a 33 K protein in rod outer segments of rat retina
17. A novel complex from bovine visual cells of a 33,000-dalton phosphoprotein with β- and γ-transducin: purification and subunit structure
18. Phosphodiesterase probes show distinct defects in rd mice and Irish setter dog disorders
19. Characterization of a phosphodiesterase-immunoreactive polypeptide from rod photoreceptors of developing rd mouse retinas
20. The photoreceptor-specific 33 kDa phosphoprotein of mammalian retina: generation of monospecific antibodies and localization by immunocytochemistry
21. Abnormal guanosine 3′5′-monophosphate during photoreceptor degeneration in the inherited retinal disorder of C3H/HeJ mice
22. The regulatory components of adenylate cyclase and transducin: a family of structurally homologous guanine nucleotide-binding proteins
23. Characterization of transducin from bovine rod outer segments: use of monoclonal antibodies to probe the structure and function of the subunit
24. Immunological determination of transducin contents in retinas exhibiting inherited degeneration
25. Determination of total protein
26. Relationships within the family of GTP-binding proteins isolated from bovine central nervous system
27. Assay of protein in the presence of high concentrations of sulfhydryl components
28. Development and degeneration of retina in rds mutant mice: light microscopy
29. Cyclic nucleotide content and phosphodiesterase activity in the rds mouse (020/A) retina
30. 1 from bovine brain require T for association with phospholipid vesicles
31. Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brains
32. Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)
33. Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments