Role of oxygen in regulation of glycolysis and lactate production in human skeletal muscle

Exercise and Sport Sciences Reviews

Volumn 18, Issue 1, 1990, Pages 1-28

  Katz, Abram ^a   Sahlin, Kent ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID DERIVATIVE; OXYGEN;

DRUG EFFECT; EXERCISE; GLYCOLYSIS; HUMAN; METABOLISM; MUSCLE; MUSCLE CONTRACTION; OXYGEN CONSUMPTION; PHYSIOLOGY; REVIEW;

EXERCISE; GLYCOLYSIS; HUMAN; LACTATES; MUSCLE CONTRACTION; MUSCLES; OXYGEN; OXYGEN CONSUMPTION; SUPPORT, NON-U.S. GOV'T;

EID: 0025159523     PISSN: 00916331     EISSN: 15383008     Source Type: Journal    
DOI: 10.1249/00003677-199001000-00004     Document Type: Article

References (127)

1. Ahlborg B, Bergström J, Ekelund LG, Guarnieri G, Harris RC, Hultman E, Nordesjö LO: Muscle metabolism during isometric exercise performed at constant force. J Appl Physiol 33:224–228, 1972.
2. Akerboom TPM, Van Der Meer R, Tager JM: Techniques for the investigation of intracellular compartmentation. In Techniques in the Life Sciences. Biochemistry. Techniques in Metabolic Research. Amsterdam, Elsevier, B2 (Part l)(B205):1–33, 1979.
3. Andersen P, Saltin B: Maximal perfusion of skeletal muscle in man. J Physiol 366:233–249, 1985.
4. Andres R, Cader G, Zierler KL: The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest 34:671–682, 1956.
5. Armstrong LE, Costill DL, Wright GA: Day-to-day variation in respiratory exchange data during cycling and running (Abstract). Med. Sci Sports Exerc 15:141–142, 1983.
6. Bang O: The lactate content of blood during and after muscular exercise in man. Scand Arch Physiol Suppl 74:51–82, 1936.
7. Bergström J, Hermansen L, Hultman E, Saltin B: Diet, muscle glycogen and physical performance. Acta Physiol Scand 71:140–150, 1967.
8. Blomstrand E, Ekblom B, Newsholme EA: Maximum activities of key glycolytic and oxidative enzymes in human muscle from differently trained individuals. J Physiol 381:111–118, 1986.
9. 2) in human muscle during static exercise and occlusion. In Knuttgen HG, Vogel JA, Poortmans J (eds): Biochemistry of Exercise. Champaign, IL, Human Kinetics, 1983, pp 781–786.
10. Broberg S, Katz A, Sahlin K: Propranolol enhances adenine nucleotide degradation in human skeletal muscle during exercise. J Appl Physiol 65:2478–2483, 1988.
11. Brooks GA: Anaerobic threshold; review of the concept and directions for future research. Med Sci Sports Exerc 17:22–31, 1985.
12. Bylund-Fellenius A-C, Walker PM, Elander A, Holm S, Holm J, Schersten T: Energy metabolism in relation to oxygen partial pressure in human skeletal muscle during exercise. Biochem J 200:247–255, 1981.
13. Carraro F, Klein S, Rosenblatt JI, Wolfe RR: Effect of dichloroacetate on lactate concentration in exercising humans. J Appl Physiol 66:591–597, 1989.
14. Challis RAJ, Arch JRS, Newsholme EA: The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle. Biochem J 221:153–161, 1984.
15. Chance B: Reaction of oxygen with the respiratory chain in cells and tissues. J Gen Physiol 49:163–188, 1965.
16. Chance B: Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Circ Res 38 (Suppl I):131–138, 1976.
17. Chance B, Williams GR: Respiratory enzymes in oxidative phosphorylation. III. The steady state. J Biol Chem 217:409–427, 1955.
18. Chasiotis D, Hultman E: The effect of circulatory occlusion on the glycogen phosphorylase-synthetase system in human skeletal muscle. J Physiol 345:167–173, 1983.
19. Chastiotis D, Sahlin K, Hultman E: Regulation of glycogenolysis in human muscle in response to epinephrine infusion. J Appl Physiol 54:45–50, 1983.
20. Chasiotis D, Hultman E: The effect of adrenaline infusion on the regulation of glycogenolysis in human muscle during isometric contraction. Acta Physiol Scand 123:55–60, 1985.
21. Connett RJ, Gayeski TEJ, Honig CR: Lactate accumulation in fully aerobic, working dog gracilis muscle. Am J Physiol 246:H120–H128, 1984.
22. 2 in a working red muscle in situ. Am J Physiol 61:H402–H408, 1986.
23. Cooke R, Pate E: The effects of ADP and phosphate on the contraction of muscle fibers. Biophys J 48:789–798, 1985.
24. Dawson MJ, Gadian DG, Wilkie DR: Muscular fatigue investigated by phosphorus nuclear magnetic resonance. Sature 274:861–866, 1978.
25. Dobson GF, Yamamoto E, Hochachka PW: Phosphofructokinase control in muscle: nature and reversal of pH-dependent ATP inhibition. Am J Physiol 250:R71–R76,1986.
26. Duboc D, Muffat-Joly M, Renault G, Degeorges M, Toussaint M, Pocidalo J-J: In situ NADH laser fluorimetry of rat fast- and slow-twitch muscles during tetanus. J Appl Physiol 64:2692–2695, 1988.
27. Edwards RHT, Hill DK, McDonnell M: Myothermal and intramuscular pressure measurements during isometric contractions of the human quadriceps muscle. J Physiol 224:58P–59P, 1972.
28. Essen B, Jansson E, Henriksson J, Taylor AW, Saltin B: Metabolic characteristics of fibre types in human skeletal muscle. Acta Physiol Scand 95:153–165, 1974.
29. Ferenzci MA, Homsher E, Trentham DR: The kinetics of magnesium adenosine triphosphate cleavage in skinned muscle fibres of the rabbit. J Physiol 352:575–599, 1984.
30. Foe LG, Kemp RG: Properties of phospho and dephospho forms of muscle phosphofructokinase. J Biol Chem 257:6368–6372, 1982.
31. Galbo H: Hormonal and Metabolic Adaptation to Exercise. Stuttgart, Georg Thieme, 1983.
32. 2 for maximum cytochrome turnover in red muscle in situ. Am J Physiol 252:H906–H915, 1987.
33. Gerschman R: Biological effects of oxygen. In Dickens F, Neil E (eds): Oxygen in the Animal Organism. Oxford, Pergamon Press, 1964, pp 475–494.
34. Gollnick PD, Piehl K, Saltin B: Selective glycogen depletion pattern in human muscle fibers after exercise of varying intensity and at varying pedalling rates. J Physiol 241:45–57, 1974.
35. Gollnick PD, Pernow B, Essen B, Jansson E, Saltin B: Availability of glycogen and plasma FFA for substrate utilization in leg muscle of man during exercise. Clin Physiol 1:27–42, 1981.
36. Graham TE, Saltin B: Estimation of the mitochondrial redox state in human skeletal muscle during exercise. J Appl Physiol 66:561–566, 1989.
37. Guha SK, Rose ZB: The enzymatic synthesis of ribose 1,5-bisphosphate: studies on its role in metabolism. Arch Biochem Biophys 250:513–518, 1986.
38. Hagberg JM, Hickson RC, Ehsani AA, Holloszy JO: Faster adjustment to and recovery from submaximal exercise in the trained state. J Appl Physiol 48:218–224, 1980.
39. Hampson NB, Piantadosi CA: Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia. J Appl Physiol 64:2449–2457, 1988.
40. Harris RC, Essen B, Hultman E: Glycogen phosphorylase activity in biopsy samples and single muscle fibres of musculus quadriceps femoris of man at rest. Scand J Clin Lab Invest 36:521–526, 1976.
41. Harris RC, Hultman E, Sahlin K: Glycolytic intermediates in human muscle after isometric contraction. Pflugers Arch 389:277–282, 1981.
42. Harris RC, Edwards RHT, Hultman E, Nordesjö LO, Nylind B, Sahlin K: The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pflugers Arch 367:137–142, 1976.
43. Henriksson J: Training induced adaptation of skeletal muscle and metabolism during submaximal exercise. J. Physiol 270:661–675, 1977.
44. Henriksson J, Katz A, Sahlin K: Redox state changes in human skeletal muscle after isometric contraction. J Physiol 380:441–451, 1986.
45. Hill AV, Long CNH, Lupton H: Muscular exercise, lactate acid, and the supply and utilization of oxygen. VI. The oxygen debt at the end of exercise. Proc R Soc Lond (Biol) B97:127–137, 1924.
46. Hintz CS, Chi MMY, Lowry OH: Heterogeneity in regard to enzymes and metabolites within individual muscle fibers. Am J Physiol 246:C288–C292, 1984.
47. Hoelzer DR, Dalsky GP, Schwartz NS, Clutter WE, Shah SD, Holloszy JO, Cryer PE: Epinephrine is not critical to prevention of hypoglycemia during exercise in humans. Am J Physiol 251:E104–E110, 1986.
48. Hofer HW: Phosphorylation of phosphofructokinase—the possible role of covalent modification in the regulation of glycolysis. In Beitner R (ed): Regulation of Carbohydrate Metabolism. Boca Raton, FL, CRC Press, 1985, pp 105–141.
49. Holloszy JO: Adaptations of skeletal muscle to endurance exercise. Med Sci Sports Exerc 7:155–164, 1975.
50. Holloszy JO, Coyle EF: Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56:831–838, 1984.
51. Hue L, Blackmore PF, Shikama H, Robinson-Steiner A, Exton JH: Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs. J Biol Chem 257:4308–4313, 1982.
52. 2 on cardiopulmonary and metabolic responses to exercise. J Appl Physiol 24:336–347, 1968.
53. Hultman E, Bergström J, McLennan Anderson N: Breakdown and resynthesis of phosphorylcreatine and adenosine triphosphate in connection with muscular work in man. Scand J Clin Lab Invest 19:56–66, 1967.
54. Idström J-P, Harihara Subramanian V, Chance B, Schersten T, Bylund-Fellenius A-C: Oxygen dependence of energy metabolism in contracting and recovering rat skeletal muscle. Am J Physiol 248:H40–H48, 1985.
55. Jansson E, Hjemdahl P, Kaijser L: Epinephrine-induced changes in muscle carbohydrate metabolism during exercise in male subjects. J Appl Physiol 60:1466–1470, 1986.
56. Jöbsis FF, Stainsby WN: Oxidation of NADH during contractions of circulated mammalian skeletal muscle. Respir Physiol 4:292–300, 1968.
57. 2 and ATP. Am J Physiol 250:C663–C675, 1986.
58. Jorfeldt L, Juhlin-Dannfelt A, Karlsson J: Lactate release in relation to tissue lactate in human skeletal muscle during exercise J Appl Physiol 44:350–352, 1978.
59. Juhlin-Dannfelt A, Aström H: Influence of β-adrenoceptor blockade on leg blood flow and lactate release in man. Scand J Clin Lab Invest 39:179–183, 1979.
60. Kaiser P, Tesch PA: Muscle lactate accumulation during exercise following β-adrenergic blockade. Acta Physiol Scand 117:149–151. 1983.
61. Karlsson J, Nordesjö LO, Jorfeldt L, Saltin B: Muscle lactate, ATP and CP levels during exercise after physical training in man. J Appl Physiol 33:199–203, 1972.
62. Karpatkin S, Helmreich E, Cori CF: Regulation of glycolysis in muscle. II. Effect of stimulation and epinephrine in isolated frog sartorius muscle. J Biol Chem 234:3139–3145, 1964.
63. Katz A, Broberg S, Sahlin K, Wahren J: Muscle ammonia and amino acid metabolism during dynamic exercise in man. Clin Physiol 6:365–379, 1986.
64. Katz A, Broberg S, Sahlin K, Wahren J: Leg glucose uptake during maximal dynamic exercise in humans. Am J Physiol 251:E65–E70, 1986.
65. Katz A, Sahlin K, Henriksson J: Muscle ATP turnover data during isometric contraction in humans. J Appl Physiol 60:1839–1842, 1986.
66. Katz A, Sahlin K, Henriksson J: Muscle ammonia metabolism during isometric contraction in humans. Am J Physiol 250:C834–C840. 1986.
67. Katz A, Sahlin K: Effect of decreased oxygen availability on NADH and lactate contents in human skeletal muscle during exercise. Acta Physiol Scand 131:119–128, 1987.
68. Katz A, Edlund A, Sahlin K: NADH content and lactate production in the perfused rabbit heart. Acta Physiol Scand 130:193–200, 1987.
69. Katz A: Mitochondrial redox state in skeletal muscle cannot be estimated with glutamate dehydrogenase system. Am J Physiol 254:C587–C588, 1988.
70. 2, glycolysis, and energy metabolism during circulatory occlusion in human skeletal muscle. Am J Physiol 255:C140–C144, 1988.
71. 2. J Appl Physiol 65:487–489, 1988.
72. Katz A, Sahlin K: Regulation of lactic acid production during exercise. J Appl Physiol 65:509–518, 1988.
73. Katz A, Nyomba BL: Mechanism of insulin-mediated glycolysis in human skeletal muscle (Abstract). Diabetes 37 (Suppl 1):72A, 1988.
74. 2 in mediating insulin-stimulated glycolysis in human skeletal muscle (Abstract). FASEB J 3:A540, 1989.
75. Katz J: The application of isotopes to the study of lactate metabolism. Med Sci Sports Exerc 18:353–359, 1985.
76. Kennedy FG, Jones DP: Oxygen dependence of mitochondrial function in isolated cardiac myocytes. Am J Physiol 250:C374–C383, 1986.
77. Kitajima S, Sakakibara R, Uyeda K: Significance of phosphorylation of phosphofructokinase. J Biol Chem 258:13292–13298, 1983.
78. Knuttgen HG, Saltin B: Oxygen uptake, muscle high-energy phosphates, and lactate in exercise under acute hypoxic conditions in man. Acta Physiol Scand 87:368–376, 1973.
79. 31P-NMR and NAD(P)H fluorescence study. Biochim Biophys Acta 893:398–408, 1987.
80. Kretzschmar KM, Wilkie DR: A new approach to freezing tissues rapidly (Abstract). J Physiol 202:66P–67P, 1969.
81. Kuo HJ, Malencik DA, Liou RS, Anderson SR: Factors affecting the activation of rabbit muscle phosphofructokinase by actin. Biochemistry 25:1278–1286, 1986.
82. Lee AD, Katz A: Transient increase in glucose 1,6-bisphosphate in human skeletal muscle during isometric contraction. Biochem J 258:915–918, 1989.
83. Linnarsson D, Karlsson J, Fagraeus L, Saltin B: Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J Appl Physiol 36:399–402, 1974.
84. Lowenstein JM: Ammonia production in muscle and other tissues: the purine nucleotide cycle. Physiol Rev 52:382–414, 1972.
85. Lowry OH, Passonneau JV: Kinetic evidence for multiple binding sites on phosphofructokinase. J Biol Chem 241:2268–2279, 1966.
86. Lundin G, Ström G: The concentration of blood lactic acid in man during muscular work in relation to the partial pressure of oxygen of the inspired air. Acta Physiol Scand 13:253–266, 1947.
87. Mansour TE: Phosphofructokinase activity in skeletal muscle extracts following administration of epinephrine. J Biol Chem 247:6059–6066, 1972.
88. Masters C: Interactions between glycolytic enzymes and components of the cytomatrix. J Cell Biol 99:222S–225S, 1984.
89. Mayr GW: Interaction of calmodulin with muscle phosphofructokinase. Interplay with metabolic effectors of the enzyme under physiological conditions. Eur J Biochem 143:521–529, 1984.
90. McGilvery RW, Murray TM: Calculated equilibria of phosphocreatine and adenosine phosphates during utilization of high energy phosphate by muscle. J Biol Chem 249:5845–5850, 1974.
91. Meyer RA, Sweeney HL, Kushmerick MJ: A simple analysis of the “phosphocreatine shuttle.” Am J Physiol 246:C365–C377, 1984.
92. Meyer RA, Dudley GA, Terjung RL: Ammonia and IMP in different skeletal muscle fibers after exercise in rats. J Appl Physiol 49:1037–1041, 1989.
93. Newsholme E, Start C: Regulation in Metabolism. London, Wiles, 1974.
94. Ottaway JH, Mowbray J: The role of compartmentation in the control of glycolysis. Curr Top Cell Regul 12:107–208, 1977.
95. Özand P, Narahara HT : Regulation of glycolysis in muscle. III. Influence of insulin, epinephrine and contraction on phosphofructokinase activity in frog skeletal muscle. J Biol Chem 239:3146–3152, 1964.
96. Pirnay F, Lamy M, Dujardin J, Deroanne R, Petit JM: Analysis of femoral venous blood during maximum muscular exercise. J Appl Physiol 33:289–292, 1972.
97. Ren JM, Henriksson J, Katz A, Sahlin K: NADH content in type I and type II human muscle fibres after dynamic exercise. Biochem J 251:183–187, 1988.
98. Richter EA, Galbo H: High glycogen levels enhance glycogen breakdown in isolated contracting muscle. J Appl Physiol 61:827–831, 1987.
99. Rowell LB, Blackmon JR, Kenny MA, Escourrou P: Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans. Am J Physiol 247:H251–H258, 1984.
100. Sahlin K: NADH and lactate in human skeletal muscle during short-term intense exercise. Pflugers Arch 403:193–196, 1985.
101. Sahlin K, Katz A: The content of NADH in rat skeletal muscle at rest and after cyanide poisoning. Biochem J 239:245–248, 1986.
102. Sahlin K, Ren JM, Broberg S: Oxygen deficit at the onset of submaximal exercise is not due to a delayed oxygen transport. Acta Physiol Scand 134:175–180, 1988.
103. Sahlin K, Harris RC, Hultman E: Creatine kinase equilibrium and lactate content compared with muscle pH in tissue samples obtained after isometric exercise. Biochem J 152:173–180, 1975.
104. Sahlin K, Palmskog G, Hultman E: Adenine nucleotide and IMP contents of the quadriceps muscle in man after exercise. Pflugers Arch 374:193–198, 1978.
105. Sahlin K: NADH and NADPH in human skeletal muscle at rest and during ischaemia. Clin Physiol 3:477–485, 1983.
106. Sahlin K: Metabolic changes limiting muscle performance. In Saltin B (ed): Biochemistry of Exercise VI. Champaign, IL, Human Kinetics, 1986, pp 323–343.
107. Sahlin K: Lactate production cannot be measured with tracer techniques. Am J Physiol 252:E439–E440, 1987.
108. Sahlin K, Katz A, Henriksson J: Redox state and lactate accumulation in human skeletal muscle during dynamic exercise. Biochem J 245:551–556, 1987.
109. Sahlin K, Katz A: Purine nucleotide metabolism. In Poortmans JR (ed): Principles of Exercise Biochemistry, Med. Sport Sci., Basel, Karger 27:120–139, 1988.
110. Sahlin K, Broberg S, Ren JM: Formation of inosine monophosphate (IMP) in human skeletal muscle during incremental dynamic exercise. Acta Physiol Scand 136:195–200.
111. Sahlin K, Katz A: Hypoxaemia increases the accumulation of inosine monophosphate (IMP) in human skeletal muscle during submaximal exercise. Acta Physiol Scand 136:199–203.
112. Saltin B, Nazar K, Costill DL, Stein E, Jansson E, Essen B, Gollnick P: The nature of the training response; peripheral and central adaptations to one-legged exercise. Acta Physiol Scand 96:289–305, 1976.
113. Schantz P: Plasticity of human skeletal muscle. Acta Physiol Scand Suppl 558. 1986.
114. Sjödin B: Lactate dehydrogenase in human skeletal muscle. Acta Physiol Scand Suppl 436, 1976.
115. Sjöholm H, Sahlin K, Edström L, Hultman E: Quantitative estimation of anaerobic and oxidative energy metabolism and contraction characteristics in intact human skeletal muscle in response to electrical stimulation. Clin Physiol 3:227–239, 1983.
116. Spriet LL, Söderlund K. Bergström M, Hultman E: Skeletal muscle glycogenolysis glycolysis and pH during electrical stimulation in men. J Appl Physiol 62:616–621. 1987.
117. Spriet LL. Ren JM. Hultman E: Epinephrine infusion enhances muscle glvcogenolvsis during prolonged electrical stimulation. J Appl Physiol 64:1439–1444. 1988.
118. Stainsby WN, Sumners C, Eitzman PD: Effects of catecholamines on lactic acid output during progressive working contractions. J Appl Physiol 59:1809–1814, 1985.
119. Sugden PH, Newsholme EA: The effects of ammonia, inorganic phosphate and potassium ions on the activity of phosphofructokinases from muscle and nervous tissues of vertebrates and invertebrates. Biochem J 150:113–122, 1975.
120. Vaughan H, Thornton SD, Newsholme EA: The effects of calcium ions on the activities of trehalase, hexokinase, phosphofructokinase, fructose diphosphatase and pyruvate kinase from various muscles. Biochem J 132:527–535, 1973.
121. Veech RL, Lawson JWR, Cornell NW, Krebs HA: Cytosolic phosphorylation potential. J Biol Chem 254:6538–6547, 1979.
122. Vogel JA, Gleser MA: Effect of carbon monoxide on oxygen transport during exercise. J Appl Physiol 32:234–239, 1972.
123. Wheeler TJ, Lowenstein JM: Adenylate deaminase from rat muscle. Regulation by purine nucleotides and orthophosphate in the presence of 150 mM KCl. J Biol Chem 254:8894–8899, 1979.
124. 31P NMR studies of resting muscle in normal human subjects. In Pollack GM, Suai H (eds): Contractile Mechanisms in Muscle. England, Plenum, 1984, pp 333–346.
125. Wilson DF, Erecinska M, Drown C, Silver IA: Effect of oxygen tension on cellular energetics. Am J Physiol 233:C135–C140, 1977.
126. Wolfe RR, Jahoor F, Miyoshi M: Evaluation of the isotopic equilibration between lactate and pyruvate. Am J Physiol 254:532–535, 1988.
127. 2 transport at rest, submaximal, and maximal work. J Appl Physiol 44:36–43, 1978.