SCOPUS 정보 검색 플랫폼

Volumn 31, Issue 47, 1990, Pages 6797-6798

Synthesis of chiral building blocks for selective adenosine receptor agents. Lipase-catalyzed resolution of 2-benzylpropanol and 2-benzylpropionic acid.

(2) Delinck, Deborah L a Margolin, Alexey L a

a Indianapolis University (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYLPROPANOL; 2 METHYL 3 PHENYLPROPIONIC ACID; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL;

EID: 0025151315 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/S0040-4039(00)97174-0 Document Type: Article

Times cited : (40)

References (12)

1
- 0024214676
- (1988) Progress in Drug Research , vol.32 , pp. 249
- Testa¹ Mayer²

2
- 0021981080
- (1984) Adv. Cyclic Nucleotide Protein Phosporylation Res. , vol.19 , pp. 29
- Daly¹

3
- 84918633805
- submitted for publication
- (1990) J. Med. Chem.
- Peet¹ Lentz² Meng³ Dudley⁴ Ogden⁵ Demeter⁶ Weintraub⁷ Bey⁸

4
- 0025099721
- (1990) Tetrahedron Lett. , vol.31 , pp. 811
- Lentz¹ Peet²

5
- 0000714772
- For reviews see
- (1986) Tetrahedron , vol.42 , pp. 3351
- Jones¹

6
- 84990106353
- General Aspects and Optimization of Enantioselective Biocatalysis in Organic Solvents: The Use of Lipases[New Synthetic Methods(76)]
- Int. Ed. Engl.
- (1989) Angewandte Chemie International Edition in English , vol.28 , pp. 695
- Chen¹ Sih²

7
- 0642367795
- (1990) Acc. Chem. Res. , vol.23 , pp. 114
- Klibanov¹

8
- 84918648817
- 4, respectively.

9
- 20644469267
- (1982) J. Amer. Chem. Soc. , vol.104 , pp. 7294
- Chen¹ Fujimoto² Gidraukas³ Sih⁴

10
- 84918647213
- 0.2 g of 1, Vinyl acetate (2 eq; 0.26 mL) and70 mg lipase P were combined in 14 mL t-BuOMe and mixture was stirred. After 2.5 h, reaction was stopped by filtering enzyme. Products were separated by radial chromatography (5% EtOAc/hexane).

11
- 84918610773
- 3g of 3 was suspended in 300 mL buffer, enzyme (3g) was added, and mixture was stirred. After 3 h, ester was extracted with hexana from basic solution (pH 8–9) and acid was extracted with EtOAc from acidic solution (pH 2).

12
- 84918649073
- 3).

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