Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

Journal of Cerebral Blood Flow and Metabolism

Volumn 10, Issue 5, 1990, Pages 740-747

  Logan, Jean ^a   Fowler, Joanna S ^b   Volkow, Nora D ^b   Wolf, Alfred P ^b   Dewey, Stephen L ^b   Schlyer, David J ^b   MacGregor, Robert R ^b   Hitzemann, Robert ^b   Bendriem, Bernard ^b   John Gatley, S ^b   Christman, David R ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NONE

Author keywords

Cocaine; Compartmental modeling; Graphical analysis; PET; Receptors; Transfer constants

Indexed keywords

3' METHYLCOCAINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN; COMPARTMENT KINETICS; HUMAN CELL; HUMAN EXPERIMENT; MALE; MATHEMATICAL ANALYSIS; METHODOLOGY; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

BRAIN; CARBON RADIOISOTOPES; COCAINE; HUMAN; LIGANDS; LINEAR MODELS; MODELS, NEUROLOGICAL; RECEPTORS, DOPAMINE; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0025127930     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.1990.127     Document Type: Article

References (17)

1. Carson RE (1986) Parameter estimation in positron emission tomography. In: Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart (Phelps M, Mazziotta, Scheiben H, eds), New York, Raven Press, pp 347-390
2. Fowler J, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, Mac-Gregor RR, Hitzemann R, Logan J, Bendriem B, Gatley J, Christman D (1989) Mapping cocaine binding sites in human and baboon brain in vivo. Synapse 4:371-377
3. 11C-carfentanil binding to opiate receptors in humans measured by positron emission tomography. J Cereb Blood Flow Metab 9:398-409
4. Gjedde A (1981) High- and low-affinity transport of D-glucose from blood to brain. J Neurochem 36:1463-1471
5. Gjedde A (1982) Calculation of cerebral glucose phosphorylation from the brain uptake of glucose analogs in vivo: a reexamination. Brain Res 4:237-274
6. Gjedde A, Wong DF, Wagner HN Jr (1986) Transient analysis of irreversible and reversible tracer binding in human brain in vivo. In: PET and NMR: New Perspectives in Neuroimaging and in Clinical Neurochemistry (Battistin L, ed), New York, Alan R. Liss, pp 223-235
7. Kennedy LT, Hanbauer I (1983) Sodium-sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites. J Neurochem 41:171-178
8. Logan J, Wolf AP, Shiue CY, Fowler JS (1987) Kinetic modeling of receptor-ligand binding applied to positron emission tomographic studies with neuroleptic tracers. J Neurochem 48:73-87
9. 11C-cocaine in the baboon brain. J Nucl Med 30:898
10. Mintun MA, Raichle ME, Kilbourn MR, Wooten GF, Welch MJ (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neural 15:217-227
11. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7
12. Patlak CS, Blasberg RG (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5:584-590
13. 11C labeled carboxyhemoglobin. J Nucl Med 20:328-334
14. Press WH, Flannery BP, Teukolsky SA, Vetterling WT (1986) Numerical Recipes. The art of Scientific Computing. Cambridge, Cambridge University Press
15. 3H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinsons disease. Naunyn Schmiedebergs Arch Pharmacol 329:227-235
16. Shampine LF, Gordon MK (1975) Computer Solution of Ordinary Differential Equations: The Initial Value Problem. San Francisco, W.H. Freeman, pp 289-293
17. Wong DF, Wagner HN Jr., Dannals RF, Links JM, Frost JJ, Ravert HT, Wilson AA, Rosenbaum AE, Gjedde A, Douglass KH, Petronis JD, Folstein JK, Toung JKT, Burns HD, Kuhar MJ (1984) Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain. Science 226:1393-1396