Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom

Toxicon

Volumn 28, Issue 7, 1990, Pages 847-856

  Schweitz, Hugues ^a   Bidard, Jean Noël ^a   Lazdunski, Michel ^a  

^a CNRS   (France)

Author keywords

classical abbreviation for Toxin I from Dendroaspis polylepis, is the purified chromatographic fraction I2; DTXI

Indexed keywords

DENDROTOXIN; PEPTIDE; SNAKE VENOM;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONVULSION; GUINEA PIG; ILEUM CONTRACTION; MOUSE; NONHUMAN; PROTEIN PURIFICATION;

ANIMALIA; APOIDEA; CAVIA PORCELLUS; CROCODYLUS NILOTICUS; DENDROASPIS; DENDROASPIS POLYLEPIS; DENDROASPIS POLYLEPIS POLYLEPIS; POLYLEPIS; SERPENTES; SUS SCROFA;

EID: 0025113314     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(09)80007-X     Document Type: Article

References (33)

1. Structure of the voltage-dependent potassium channel is highly conserved from drosophila to vertebrate central nervous systems
2. Toxin from the snake Dendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fiber
3. + channels, have interacting receptor sites
4. + channel toxins, MCD peptide and dendrotoxin I
5. Excitatory effects of dendrotoxin on the hippocampus
6. Botulinum neurotoxin and dendrotoxin as probes for studies on neurotransmitter release
7. Classification of scorpion toxins according to amino acid composition and sequence
8. Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release
9. Fasciculins, anticholinesterase toxins from the venom of the green mamba
10. Identification by cross-linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide
11. + channels from mammalian skeletal muscle
12. An emerging pharmacology of peptide toxins targeted against potassium channels
13. Dendrotoxin, a selective blocker of a non-inactivating potassium current in guinea pig dorsal root ganglion neurones
14. +-channel protein identified by its binding properties for dendrotoxin I
15. + channels
16. + channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations
17. Diversity and ubiquity of K channels
18. Lethal potency in mice of toxins from scorpion, sea anemone, snake and bee venoms following intraperitoneal and intracisternal injection
19. A micro-radioimmunoassay for apamin
20. Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus and Actinodendron plumosum
21. Purification, sequence, and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel
22. Purification, subunit structure and pharmacological effects on cardiac and smooth muscle cells of a polypeptide toxin isolated from the marine snail
23. + channels
24. + channels in dorsal root ganglion cells
25. Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast activating potassium current and bind to common neuronal proteins
26. Snake venom toxins. The amino acid sequences of two toxins from Dendroaspis polylepis polylepis (black mamba) venom
27. Protease inhibitor as snake venom toxins
28. Snake venom toxins. Purification and properties of low molecular weight polypeptides of Dendroaspis polylepis polylepis (black mamba venom)
29. Snake venom toxins. The amino-acid sequence of a short-neurotoxin homologue from Dendroaspis polylepis polylepis (black mamba) venom
30. The amino acid sequence of a weak trypsin inhibitor B from Dendroaspis polylepis polylepis (black mamba) venom
31. Potassium channels expressed from rat brain cDNA have delayed rectifier properties
32. The characterization of high affinity binding sites in rat brain for the mast cell degranulating peptide from the bee venom using the purified monoiodinated peptide
33. Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin