Identification of muscarinic receptor subtypes present in cerebellar granule cells: Prevention of [3H]propylbenzilyl choline mustard binding with specific antagonists

Neuropharmacology

Volumn 29, Issue 9, 1990, Pages 861-868

  McLeskey, Sandra W ^a   Wojcik, W J ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cerebellar granule cells; cerebellum; ligand binding; muscarinic receptors; primary culture; receptor identification; receptor subtypes

Indexed keywords

ATROPINE; METHOCTRAMINE; MUSCARINIC RECEPTOR; PIRENZEPINE; RADIOISOTOPE; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CEREBELLUM; GRANULE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ADENYLATE CYCLASE; ANIMAL; ATROPINE; CELL MEMBRANE; CELLS, CULTURED; CEREBELLUM; DIAMINES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; PARASYMPATHOLYTICS; PIRENZEPINE; PROPYLBENZILYLCHOLINE MUSTARD; QUINUCLIDINES; RECEPTORS, MUSCARINIC; XANTHENES;

EID: 0025111262     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(90)90161-J     Document Type: Article

References (18)

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3. 5 muscarinic acetylcholine receptor genes
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5. Desensitization of the muscarinic receptors which inhibit adenylate cyclase in cerebellar granule cells
6. Propybenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor
7. Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase
8. An alkylating derivative of benzilylcholine with specific and long-lasting parasympatholytic activity
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10. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
11. 3H]Propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclse in two cultured cell lines
12. Molecular cloning and expression of a fifth muscarinic acetylcholine receptor
13. Specificity of methoctramine in blocking muscarinic receptors which inhibit adenylate cyclase in cerebellar granule cells
14. The activation of inositol phospholipid metabolism as a signaltransducing system for excitatory amino acids in primary cultures of cerebellar granule cells
15. Distinct primary structures, ligand-binding properties and tissue expression of four human muscarinic acetylcholine receptors
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