Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas

Journal of Clinical Investigation

Volumn 86, Issue 3, 1990, Pages 900-908

  Zakut, Haim ^a,c   Ehrlich, Gal ^b   Ayalon, An ^a,b   Prody, Catherine A ^b   Malinger, Gustavo ^a,b   Seidman, Shlomo ^b   Ginzberg, Dalia ^b   Kehlenbach, Ralph ^b   Soreq, Hermona ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c WOLFSON MEDICAL CENTER   (Israel)

Author keywords

Cytochemical staining; Immunofluorescence; In situ hybridization; Oncogenes coamplification; Xenopus oocyte bioassay

Indexed keywords

ACETYLCHOLINESTERASE;

ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BUTYRYLCHOLINESTERASE; CARCINOMA; CHOLINESTERASES; FEMALE; GENE AMPLIFICATION; HUMAN; NUCLEIC ACID HYBRIDIZATION; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T;

EID: 0025104396     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI114791     Document Type: Article

References (38)

1. Soreq, H., and C. A. Prody. 1989. Sequence similarities between human acetylcholinesterase and related proteins: putative implications for therapy of anticholinesterase intoxication. In Computer-assisted Modeling of Receptor-Ligand Interactions, Theoretic Aspects and Application to Drug Design. A. Golombek and R. Rein, editors. Alan R. Liss, New York. 347-359.
2. Prody, C. A., A. Gnatt, D. Zevin-Sonkin, O. Goldberg, and H. Soreq. 1987. Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues. Proc. Natl. Acad. Sci. USA. 84:3555-3558.
3. McTiernan, C., S. Adkins, A. Chatonnet, T. A. Vaughan, C. F. Bartels, M. Kott, T. L. Rosenberry, B. LaDu, and O. Lockridge. 1987. Brain cDNA clone for human cholinesterase. Proc. Natl. Acad Sci. USA. 84:6682-6686.
4. Toutant, J. P., and J. Massoulie. 1988. Cholinesterase II-tissue and cellular distribution of the molecular forms and their physiological regulations. In The Cholinergic Synapse. V. P. Whittaker, editor. 86:167-224.
5. Seidman, S., and H. Soreq. 1990. Co-injection of Xenopus oocytes with cDNA-produced and native mRNAs: a molecular biological approach to the tissue specific processing of human cholinesterases Int. Rev. Neurobiol. 32:107-139.
6. Rakonczay, Z., and S. Brimijoin. 1988. Biochemistry and pathophysiology of the molecular forms of cholinesterases. In Subcellular Biochemistry. J. R. Harris, editor. Plenum Press, New York. 12:355-378.
7. Layer, P. G., R. Alber, and O. Sporns. 1987. Quantitative development and molecular forms of acetyl- and butyrylcholinesterase during morphogenesis and synaptogenesis of chick brain and retina. J. Neurochem. 49:175-182.
8. Prody, C. A., P. Dreyfus, R. Zamir, H. Zakut, and H. Soreq. 1989. De novo amplification within a "silent" human cholinesterase gene in a family subjected to prolonged exposure to organophosphorous insecticides. Proc. Natl. Acad. Sci. USA. 86:690-694.
9. Lapidot-Lifson, Y., C. A. Prody, D. Ginzberg, D. Meytes, H. Zakut, and H. Soreq. 1989. Co-amplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells. Correlation with various leukemias and abnormal megakaryocytopoiesis. Proc. Natl. Acad Sci. USA. 86:4715-4719.
10. Drews, E. 1975. Cholinesterase in embryonic development. Prog. Histochem. Cytochem. 7:1-52.
11. Razon, N., H. Soreq, E. Roth, A. D. Bartal, and I. Silman. 1984. Characterization of activities and forms of cholinesterases in human primary brain tumors. Exp Neurol. 84:681-695.
12. Slotman, B. J., and B. R. Rao. 1988. Ovarian cancer (review). Etiology, diagnosis, prognosis, surgery, radiotherapy, hemotherapy and endocrine therapy. Anticancer Res. 8:417-434.
13. Soreq, H., G. Malinger, and H. Zakut. 1987. Expression of cholinesterase genes in developing human oocytes revealed by in situ hybridization. Hum. Reprod. 2:689-693.
14. Malinger, G., H. Zakut, and H. Soreq. 1989. Cholinoceptive properties of human primordial, pre-antral and antral oocytes: In situ hybridization and biochemical evidence for expression of cholinesterase genes. J. Mol. Neurosci. 1:77-84.
15. Soreq, H., D. Zevin-Sonkin, and N. Razon. 1984. Expression of cholinesterase gene(s) in human brain tissues: translational evidence for multiple mRNA species. (Eur Mol. Biol. Organ.) EMBO J. 3:1371-1375.
16. Soreq, H., and A. Gnatt. 1987. Molecular biological search for human genes encoding cholinesterases. Mol. Neurobiol. 1:47-80.
17. McGuire, M. C., C. P. Nogueira, C. F. Bartels, H. Lightstone, A. Hajra, A. F. L. Van der Spek, O. Lockridge, and B. LaDu. 1989. Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase. Proc. Natl. Acad. Sci. USA. 86:953-957.
18. Dreyfus, P., D. Zevin-Sonkin, S. Seidman, C. A. Prody, R. Zisling, H. Zakut, and H. Soreq. 1988. Cross-homologies and structural differences between human cholinesterases revealed by antibodies against cDNA-produced butyrylcholinesterase peptides. J. Neurochem. 51:1858-1867.
19. Dreyfus, P. A., S. Seidman, M. Pincon-Raymond, M. Murawsky, F. Rieger, E. Schejter, H. Zakut, and H. Soreq. 1989. Tissue-specific processing and polarized compartmentalization of clone-produced cholinesterase in microinjected Xenopus oocytes. Mol. Cell. Neurobiol. 9:323-341.
20. Soreq, H., S. Seidman, P. A. Dreyfus, D. Zevin-Sonkin, and H. Zakut. 1989. Expression and tissue-specific assembly of cloned human butyrylcholinesterase in microinjected Xenopus laevis oocytes. J. Biol. Chem. 264:10608-10613.
21. Chatonnet, A., and O. Lockridge. 1989. Comparison of butyrylcholinesterase and acetylcholinesterase. Biochem. J. 260:625-634.
22. Zakut, H., L. Even, S. Birkenfeld, G. Malinger, R. Zisling, and H. Soreq. 1988. Modified properties of serum cholinesterase in primary carcinomas. Cancer (Phila.). 61:727-737.
23. Mollgard, K., K. M. Dziegielewska, N. R. Saunders, H. Zakut, and H. Soreq. 1988. Synthesis and localization of plasma proteins in the developing human brain: integrity of the fetal blood-brain barrier to endogenous proteins of hepatic origin. Dev. Biol. 128:207-221.
24. Bishop, J. M. 1987. The molecular genetics of cancer. Science (Wash. DC). 235:305-311.
25. Kohl, N. E., N. Kanda, R. R. Schreck, G. Bruns, S. A. Latt, F. Gilbert, and F. W. Alt. 1983. Transposition and amplification of oncogene-related sequences in human neuroblastoma. Cell. 35:359-367.
26. Yoshida, M. C., M. Wada, H. Satoh, T. Yoshida, H. Sakamoto, K. Miyagawa, J. Yokota, T. Koda, M. Kakinuma, T. Sugimura, and M. Terada. 1988. Human HSP1 (HSPF1) gene maps to chromosome band 11q13 and co-amplifies with the INT2 genes in human cancer. Proc. Natl. Acad. Sci. USA. 85:4861-4864.
27. Spradling, A. 1987. Results and problems in cell differentiation. In Structure and Function of Eukaryotic Chromosomes. Vol. 14. W. Hennig, editor. Springer-Verlag, Berlin/Heidelberg. 200-212.
28. Soreq, H., R. Zamir, D. Zevin-Sonkin, and H. Zakut. 1987. Human cholinesterase genes localized by hybridization to chromosomes 3 and 16. Hum. Genet. 77:325-328.
29. Layer, P. G., and O. Sporns. 1987. Spatiotemporal relationship of embryonic cholinesterases with cell proliferation in chicken brain and eye. Proc. Natl. Acad. Sci. USA 84:284-288.
30. Gnatt, A., C. A. Prody, R. Zamir, J. Lieman-Hurwitz, H. Zakut, and H. Soreq. 1990. Expression of alternatively terminated unusual CHEmRNA transcripts mapping to chromosome 3q26-ter in nervous system tumors. Cancer Res. 50:1983-1987.
31. Slamon, D. J., G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire. 1987. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science (Wash. DC). 235:177-182, 1987.
32. U. N. Security Council. 1984. Report of specialists appointed by the Secretary General, Paper 5/16433.
33. Mouches, C., N. Pasteur, J. B. Berge, O. Hyrien, M. Raymond, B. R. De Saint Vincent, M. Silvestri, and G. P. Georghiou. 1986. Amplification of an esterase gene is responsible for insecticide resistence in a California Culex mosquito. Science (Wash. DC). 233:778-780.
34. Schimke, R. T. 1984. Gene amplication in cultured animal cells. Cell. 37:705-713.
35. Scotto, K. W., J. L. Biedler, and P. W. Melera. 1986. Amplification and expression of genes associated with multidrug resistance in mammalian cells. Science (Wash. DC). 232:751-755.
36. Ahmed, F., R. Hart, and N. Lewis. 1977. Pesticide induced DNA damage and its repair in cultured human cells. Mutat. Res. 42:161-174.
37. Kiraly, J., I. Szentesi, M. Ruzicska, and A. Czeizel. 1979. Chromosome studies in workers producing organophosphate insecticides. Arch. Environ. Contamin. Toxicol. 8:309-319.
38. Raven, L., Y. Ashani, D. Levi, D. De La Hoz, A. D. Wolfe, and B. P. Doctor. 1989. Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice. Biochem. Pharmacol. 38:529-534.