DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2′-chloroethyl)-l,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)

British Journal of Cancer

Volumn 61, Issue 2, 1990, Pages 285-289

  Broggini, M ^a   Hartley, J A ^b,c   Mattes, W B ^b,d   Ponti, M ^a   Kohn, K W ^b   D'Incalci M ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d Agricultural Products Environmental Health Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(2 CHLOROETHYL) 1,4 DIAZABICYCLO[2.2.1]HEPTANE DIHYDROGEN DIMALEATE; 1,4 BIS(2 CHLOROETHYL) 1,4 DIAZACYCLOHEXANE; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BICYCLO COMPOUNDS; BRIDGED COMPOUNDS; CELL SURVIVAL; DNA DAMAGE; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; INTERPHASE; LEUKEMIA L1210; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0025101074     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1990.53     Document Type: Article

References (9)

1. ERBA, E., PEPE, S., UBEZIO, P. & 5 others (1986). Mitozolomide activity on human cancer cells in vitro. Br. J. Cancer, 54, 925.
2. EWIG, R. A. G. & KOHN, K. W. (1977). DNA damage and repair in mouse leukemia LI210 cells treated with nitrogen mustard, 1, 3- bis(2-chloroethyl)-l -nitrosourea, and other nitrosoureas. Cancer Res., 37, 2114.
3. FESSLER, D. C., PETTIT, G. R. & SETTEPANI, J. A. (1969). Antineoplastic agents. XXV. l, 4-Diazabicyclo-[2. 2. 1]-heptanes. J. Med. Chem., 12, 542.
4. KOHN, K. W., EWIG, R. A. G., ERICKSON, L. C. & ZWELLING, L A. (1981). Measurement of strand breaks and cross-links by alkaline elution. In DNA Repair. A Laboratory Manual of Research Procedures, Vol. l pt. B, Freidberg, E. C. & Hanawalt, P. C. (eds) p. 379. Marcel Dekker: New York.
5. MATTES, W. B., HARTLEY, J. A. & KOHN, K. W. (1986). DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards. Nucleic Acids Res., 14, 2971.
6. MAXAM, A. M. & GILBERT, W. (1980). Sequencing end-labeled DNA with base-specific chemical cleavage. Methods Enzymol., 65, 499.
7. PETTIT, G. R., GIESCHEN, D. P. & PETTIT, W. E. (1979). Antineoplastic agents LXIV: 1, 4-bis(2'-chloroethyl)-1, 4-diazabicyclo-[2. 2. 1]hep- tane dihydrogen, dimaleate. J. Pharm. Sci., 68, 1539.
8. ROSS, W. E., EWIG, R A G. & KOHN, K. W. (1978). Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links. Cancer Res., 38, 1502.
9. TRAGANOS, F., DARZYNKIEWICZ, Z., BUETI, C. & MELAMED, M R. (1984). Effects of a prospective antitumour agent, l, 4-bis(2'chlor- oethyl)-l, 4-diazabicyclo-[2. 2. 1] heptane diperchlorate, on cultured mammalian cells. Cancer Invest., 2, 1.