Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level

Journal of Experimental Medicine

Volumn 171, Issue 2, 1990, Pages 465-475

  Han, J ^a   Brown, T ^a   Beutler, B ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; MESSENGER RNA; TUMOR NECROSIS FACTOR;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; GENETIC ENGINEERING; HUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; ENDOTOXINS; HUMAN; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; TRANSLATION, GENETIC; TUMOR NECROSIS FACTOR;

EID: 0025098538     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.171.2.465     Document Type: Article

References (22)

1. Vaidya, A. B., N. E. Taraschi, S. L. Tancin, and C. A. Long. 1983. Regulation of endogenous murine mammary tumor virus expression in C57BL mouse lactating mammary glands: transcription of functional mRNA with a block at the translational level. J. Virol. 46:818.
2. Miller, A. D., T. Curran, and I. M. Verma. 1984. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell. 36:51.
3. Kruys, V. I., M. G. Wathelet, and G. A. Huez. 1988. Identification of a translation inhibitory element (TIE) in the 3' untranslated region of the human interferon-beta mRNA. Gene(Amst.). 72:191.
4. White, K., and H. N. Munro. 1988. Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels. J. Biol. Chem. 263:8938.
5. Yen, T. J., P. S. Machlin, and D. W. Cleveland. 1988. Autoregulated instability of β-tubu-lin mRNAs by recognition of the nascent amino terminus of β-tubulin. Nature (Lond.). 334:580.
6. Beutler, B., N. Krochin, I. W. Milsark, C. Luedke, and A. Cerami. 1986. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science (Wash. DC). 232:977.
7. Beutler, B., J. Mahoney, N. Le Trang, P. Pekala, and A. Cerami. 1985. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. J. Exp. Med. 161:984.
8. Mahoney, J. R. Jr., B. A. Beutler, N. Le Trang, W. Vine, Y. Ikeda, M. Kawakami, and A. Cerami. 1985. Lipopolysaccharide-treated RAW 264.7 cells produce a mediator which inhibits lipoprotein lipase in 3T3-L1 cells. J. Immunol. 134:1673.
9. Caput, D., B. Beutler, K. Hartog, S. Brown-Shimer, and A. Cerami. 1986. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl. Acad. Sci. USA. 83:1670.
10. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 46:659.
11. Wilson, T., and R. Treisman. 1988. Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences. Nature (Lond.). 336:396.
12. Kruys, V, M. Wathelet, P. Poupart, R. Contreras, W. Fiers, J. Content, and G. Huez. 1987. The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation. Proc. Natl. Acad. Sci. USA. 84:6030.
13. Crawford, D., K. Hagerty, and B. Beutler. 1989. Multiple splice forms of ribonuclease inhibitor mRNA differ only in the 5'-untranslated region. Gene (Amst). In press.
14. Davis, L. G., M. D. Dibner, and J. F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier Science Publishing Co., Inc., New York. 1-388.
15. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 12:1044.
16. Shaw, W. V, and R. F. Brodsky. 1968. Characterization of chloramphenicol acetyltrans-ferase from chloramphenicol-resistant Staphylococcus aureus. J. Bacteriol. 95:28.
17. Collart, M. A., D. Berlin, J. D. Vassalli, S. DeKossodo, and P. Vassalli. 1986. Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. J. Exp. Med. 164:2113.
18. Sariban, E., K. Imamura, R. Luebbers, and D. Kufe. 1988. Transcriptional and post-transcriptional regulation of tumor necrosis factor gene expression in human monocytes. J. Clin. Invest. 81:1506.
19. Walden, W. E., S. Daniels-McQueen, P. H. Brown, L. Gaffield, D. A. Russell, D. Bielser, L. C. Bailey, and R. E. Thach. 1988. Translational repression in eukaryotes: partial purification and characterization of a repressor of ferritin mRNA translation. Proc. Natl. Acad. Sci. USA. 85:9503.
20. Rouault, T. A., M. W. Hentze, S. W. Caughman, J. B. Harford, and R. D. Klausner. 1988. Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA. Science (Wash. DC). 241:1207.
21. Strickland, S., J. Huarte, D. Belin, A. Vassalli, R.J. Rickles, andJ.-D. Vassalli. 1988. Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes. Science (Wash. DC). 241:680.
22. Kruys, V, O. Marinx, G. Shaw, J. Deschamps, and G. Huez. 1989. Translational blockade imposed by cytokines-derived UA-rich sequences. Science (Wash. DC). 245:852.