Differential regulation of luteinizing hormone, follicle-stimulating hormone, and free α-subunit secretion from the gonadotrope by gonadotropin-releasing hormone (GnRH): Evidence from the use of two gnRH antagonists

Journal of Clinical Endocrinology and Metabolism

Volumn 70, Issue 2, 1990, Pages 328-335

  Hall, Janet E ^a,b   Whitcomb, Randall W ^a,b   Rivier, Jean E ^a,b   Vale, Wylie W ^a,b   Crowley, William F ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADORELIN DERIVATIVE; LUTEINIZING HORMONE; RADIOISOTOPE;

ADULT; ALPHA CHAIN; ARTICLE; FEMALE; HUMAN CELL; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLICLE STIMULATING HORMONE; FOLLICULAR PHASE; GONADORELIN; HUMAN; LUTEINIZING HORMONE; MENSTRUAL CYCLE; OVULATION; PITUITARY GLAND; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025095221     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-70-2-328     Document Type: Article

References (26)

1. Culler MD, Negro-Villar A. Pulsatile follicle-stimulating hormone secretion is independent of endogenous luteinizing hormone-releasing hormone. J Clin Endocrinol Metab. 1986;118:609-12.
2. McCann SM, Mizunuma H, Samson WK, Lumpkin MD. Differential hypothalamic control of FSH secretion: a review. Psychoneuroendocrinology. 1983;8:299-308.
3. McNeilly AS, Jonassen JA, Fraser HM. Suppression of follicular development after chronic LHRH immunoneutralization in the ewe. J Reprod Fértil. 1986;76:481-90.
4. Schwall RH, Sxonyi E, Mason AJ, Nikolics K. Activin stimulates secretion of follicle-stimulating hormone from pituitary cells desensitized to gonadotropin-releasing hormone. Biochem Biophys Res Commun. 1988;151:1099-104.
5. Vale W, Rivier J, Vaughan J, et al. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature. 1986;321:776-9.
6. Kourides IA, Weintraub BD, Ridgway EC, Maloof F. Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders. J Clin Endocrinol Metab. 1975;40:872-85.
7. Kourides IA, Re RN, Weintraub BD, Ridgway EC, Maloof F. Metabolic clearance and secretion rates of subunits of human thyrotropin. J Clin Invest. 1977;77:508-16.
8. Spratt DI, Chin WV, Ridgway EC, Crowley Jr WF. Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free a-subunit secretion. J Clin Endocrinol Metab. 1986;62:102-8.
9. Winters SJ, Troen P. α-Subunit secretion in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 1988;66:338-42.
10. Hall JE, Brodie TD, Badger TM, et al. Evidence of differential control of FSH and LH secretion by gonadotropin-releasing hormone (GnRH) from the use of a GnRH antagonist. J Clin Endocrinol Metab. 1988;67:524-31.
11. Whitcomb RW, Sangha JS, Schneyer AL, Crowley Jr WF. Improved measurement of free alpha subunit of glycoprotein hormones by assay with use of a monoclonal antibody. Clin Chem. 1988;34:2022-5.
12. Filicori M, Santoro N, Merriam GR, Crowley WF. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab. 1986;62:1136-44.
13. Corbin A, Beattie CW. Inhibition of the preovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone releasing hormone. Endocr Res Commun. 1975;2:1-23.
14. Crowley Jr WF, Beitins IZ, Vale W, et al. The biologic activity of a potent analogue of gonadotropinreleasing hormone in normal and hypogonadotropic men. N Engl J Med. 1980;302:1052-7.
15. Filicori M, Butler JP, Crowley WF. Neuroendocrine regulation of the corpus luteum in the human. J Clin Invest. 1984;73:1638-47.
16. Winters SJ, Troen P. Pulsatile secretion of immunoreactive a-subunit in man. J Clin Endocrinol Metab. 1985;60:344-8.
17. Kourides IA, Weintraub BD, Re RN, Ridgway EC, Maloof F. Thyroid hormone, oestrogen, and glucocorticoid effects on two different pituitary glycoprotein hormone alpha subunit pools. Clin Endocrinol (oxf). 1978;9:535-42.
18. Greenspan SL, Klibanski A, Schoenfeld D, Ridgway EC. Pulsatile secretion of thyrotropin in man. J Clin Endocrinol Metab. 1986;63:661-8
19. Rivier C, Rivier J, Perrin M, Vale W. Comparison of the effect of several gonadotropin releasing hormone antagonists on luteinizing hormone secretion, receptor binding and ovulation. Biol Reprod. 1983;28:374-8.
20. Rivier JE, Porter J, Rivier CL, et al. New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro. J Med Chem. 1986;29:1846-51.
21. Pavlou SN, Wakefield G, Schlechter NL, et al. Mode of suppression of pituitary and gonadal function after acute or prolonged administration of a luteinizing hormone-releasing hormone antagonist in normal men. J Clin Endocrinol Metab. 1989;68:446-54.
22. Crowley Jr WF, Filicori M, Spratt DI, Santoro NF. The physiology of gonadotropinreleasing hormone (GRAB) secretion in men and women. Recent Prog Horm Res. 1985;41:473-531.
23. Grady RR, Shin L, Charlesworth M, et al. Differential suppression of follicle-stimulating hormone secretion in vivo by a gonadotropinreleasing hormone antagonist. Neuroendocrinology. 1985;40:246-52.
24. Dahl KD, Pavlou SN, Kovacs WJ, Hsueh AJW. The changing ratio of serum bioactive to immunoreactive follicle-stimulating hormone in normal men following treatment with a potent gonadotropin releasing hormone antagonist. J Clin Endocrinol Metab. 1986;63:792-4.
25. Lincoln GA, Fraser HM. Blockade of episodic secretion of luteinizing hormone in the ram by the administration of antibodies to luteinizing hormone releasing hormone. Biol Reprod. 1979; 21:1239-45.
26. Culler MD, Negro-Villar A. Pulsatile follicle-stimulating hormone secretion is independent of luteinizing hormone-releasing hormone (LHRH): pulsatile replacement of LHRH bioactivity in LHRH immunoneutralized rats. Endocrinology. 1987;120:2011-21.