Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

Cell

Volumn 62, Issue 6, 1990, Pages 1227-1233

  Drumm, Mitchell L ^a   Pope, Heidi A ^a   Cliff, William H ^b   Rommens, Johanna M ^c   Marvin, Sheila A ^b   Tsui, Lap Chee ^c   Collins, Francis S ^a   Frizzell, Raymond A ^b   Wilson, James M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL;

ARTICLE; CYSTIC FIBROSIS; GENE THERAPY; GENE TRANSFER; HEREDITY; HUMAN; PRIORITY JOURNAL; RETROVIRUS;

ADENOCARCINOMA; CELL LINE; CHLORIDE CHANNELS; CLONE CELLS; CYCLIC AMP; CYSTIC FIBROSIS; GENE THERAPY; HUMAN; ION CHANNELS; MEMBRANE PROTEINS; PANCREATIC NEOPLASMS; RETROVIRIDAE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSDUCTION, GENETIC; TRANSFECTION;

UNIDENTIFIED RETROVIRUS;

EID: 0025094612     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(90)90398-X     Document Type: Article

References (30)

1. Human respiratory tract secretions: mucous glycoproteins of nonpurulent tracheobronchial secretions and sputum of patient with bronchitis and cystic fibrosis
2. + transport in cystic fibrosis respiratory epithelia
3. Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis
4. −-secreting epithelial cells
5. A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator protein
6. 508 mutation—report from the Cystic Fibrosis Genetic Analysis Consortium
7. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
8. Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients
9. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
10. Cystic fibrosis: a disease of ion channels
11. Altered regulation of airway epithelial cell chloride channels in cystic fibrosis
12. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
13. Identification of the cystic fibrosis gene: genetic analysis
14. Identification of mutations in regions corresponding to the two putative nucleotide (ATP) binding folds of the cystic fibrosis gene
15. Expression of human class II major histocompatibility complex antigens using retrovirus vectors
16. cAMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium
17. Cystic fibrosis: a disease in electrolyte transport
18. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
19. Identification of the cystic fibrosis gene: chromosome walking and jumping
20. Defective beta-adrenergic response of cystic fibrosis sweat glands in vivo and in vitro
21. Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells
22. A cystic fibrosis pancreatic adrenocarcinoma cell line
23. An overview
24. A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells
25. Abnormal regulation of ion channels in cystic fibrosis epithelia
26. A frameshift mutation in the cystic fibrosis gene
27. 2+ ionophores in cystic fibrosis airway epithelia
28. Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit
29. Expression of human adenosine deaminase in mice reconstituted with retrovirus-transduced hematopoietic stem cells
30. Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer