Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice

Neuroscience Letters

Volumn 117, Issue 1-2, 1990, Pages 140-143

  Piot, O ^a   Betschart, J ^a   Stutzmann, J M ^a   Blanchard, J C ^a  

^a SANOFI   (France)

Author keywords

Benzodiazepine; Cyclopyrrolone; FG 7142; Mouse; Physical dependence

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; LORAZEPAM; NITRAZEPAM; SURICLONE; TRIAZOLAM; ZOPICLONE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DEPENDENCE; DRUG WITHDRAWAL; EPILEPTIC DISCHARGE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CARBOLINES; COMPARATIVE STUDY; CONVULSANTS; DIAZEPAM; DISEASE MODELS, ANIMAL; FLUNITRAZEPAM; HYPNOTICS AND SEDATIVES; LORAZEPAM; MALE; MICE; MICE, INBRED STRAINS; PIPERAZINES; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE-RELATED DISORDERS; TRIAZOLAM;

EID: 0025085519     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(90)90133-T     Document Type: Article

References (25)

1. Pharmacologic characterization of acute chlordiazepoxide dependence in the rat
2. Studies on the dependence-inducing potential of zopiclone and triazolam
3. Benzodiazepine dependent patients and their psychological treatment
4. Evaluation of zopiclone physical dependence liability in normal volunteers
5. Behavioral pharmacology of minor tranquilizers
6. Periodic benzodiazepine antagonist administration prevents benzodiazepine withdrawal symptoms in primates
7. Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam
8. Withdrawal reactions from Chlordiazepoxide (‘Librium’)
9. The rapid development of physical dependence on barbiturates
10. Long-term anxiolytic therapy: the issue of drug withdrawal
11. The biological basis of benzodiazepine dependence
12. Chronic benzodiazepine treatment increases the effects of the inverse agonist FG 7142
13. Mice and rats are sensitized to the proconvulsant action of a benzodiazepine-receptor inverse agonist (FG 7142) following a single dose of lorazepam
14. Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426
15. Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs
16. Benzodiazepine dependence in the clinic: reason for anxiety
17. Rapid induction of lorazepam dependence and reversal with flumazenil
18. A simple and rapid method of inducing physical dependence with benzodiazepines in mice
19. Benzodiazepine dependence
20. Lorazepam and meprobamate dose effects in humans: behavioral effects and abuse liability
21. Acute effects of drug administration and withdrawal on the benzodiazepine receptor
22. Lorazepam discontinuation promotes ‘inverse agonist’ effects of benzodiazepines
23. Benzodiazepine dependence
24. Behavioral effects of the betacarboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone
25. 3H]flunitrazepam) binding sites: differences