Absorption and metabolism of capsaicinoids following intragastric administration in rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 342, Issue 3, 1990, Pages 357-361

  Donnerer, Josef ^a   Amann, Rainer ^a   Schuligoi, Rufina ^a   Lembeck, Fred ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

3H dihydrocapsaicin; Capsaicin; Degradation; Gastrointestinal absorption; In vitro incubation

Indexed keywords

CAPSAICIN; DIHYDROCAPSAICIN; RADIOISOTOPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG METABOLISM; DRUG TISSUE LEVEL; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; BRAIN; CAPSAICIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; INTESTINAL ABSORPTION; INTUBATION, GASTROINTESTINAL; MALE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0025073928     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00169449     Document Type: Article

References (15)

1. Capsaicin sensitive afferent neurons from peripheral glucose receptors mediate the insulin-induced increase in adrenaline secretion
2. Depletion of primary afferent substance P by capsaicin and dihydrocapsaicin without altered thermal sensitivity
3. Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem
4. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa
5. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa
6. In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper, in rats
7. Gastroinstestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats
8. Intragastric capsaicin enhances rat gastric acid elimination and mucosal blood flow by afferent nerve stimulation
9. Columbus, capsicum and capsaicin: past, present and future
10. Interactions of capsaicinoids with drug-metabolizing systems
11. Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig
12. Exposure to calcium free medium protects sensory fibers by capsaicin desensitization
13. Determination of capsaicin in tissues and separation of capsaicin analogues by high-performance liquid chromatography
14. Distribution of capsaicin in rat tissues after systemic administration
15. Spinal substance P transmits bradykinin but not osmotic stimuli from hepatic portal vein to hypothalamus in rat