Mechanism for the Inhibitory Effect of a Seleno-Organic Compound, Ebselen, and Its Analogues on Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes

Journal of Pharmacobio-Dynamics

Volumn 13, Issue 7, 1990, Pages 421-425

  Masayasu, Hiroyuki ^b   Ohtsuka, Toshiaki ^a   Okamura, Naoki ^a   Ishibashi, Sadahiko ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

anti inflammatory action; polymorphonuclear leukocyte; protein kinase C; seleno organic compound; superoxide anion production

Indexed keywords

2 (3 PYRIDYL) 1,2 BENZISOSELENAZOL 3(2H) ONE; 2 [2 (PHENYLCARBAMOYL)PHENYLSELENOTHIO]BUTANEDIOIC ACID; 2 METHYLSELENO N PHENYLBENZAMIDE; 2 PHENYL 1,2 BENZISOXAZOL 3(2H) ONE; 7 NITRO 2 PHENYL 1,2 BENZISOSELENAZOL 3(2H) ONE; EBSELEN; EBSELEN DERIVATIVE; N,N' DIETHYL N,N' BIS(4 FLUOROETHYL) 2,2' DISELENODIBENZAMIDE; NAT 02 761; NAT 02 801; NAT 06 099; NAT 06 123; NAT 06 513; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; NEUTROPHIL; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZOLES; COMPARATIVE STUDY; ENZYME ACTIVATION; FEMALE; GUINEA PIGS; HORSES; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; NEUTROPHILS; PROTEIN KINASE C; SELENIUM; STIMULATION, CHEMICAL; SUPEROXIDES; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; THIAZOLES;

EID: 0025061637     PISSN: 0386846X     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb1978.13.421     Document Type: Article

References (16)

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