Some Benzyl-Substituted Imidazoles, Triazoles, Tetrazoles, Pyridinethiones, and Structural Relatives as Multisubstrate Inhibitors of Dopamine β-Hydroxylase. 4.1Structure-Activity Relationships at the Copper Binding Site

Journal of Medicinal Chemistry

Volumn 33, Issue 2, 1990, Pages 781-789

  Kruse, Lawrence I ^a   Kaiser, Carl ^b   DeWolf, Walter E ^b   Finkelstein, Joseph A ^b   Frazee, James S ^b   Hilbert, Eileen L ^b   Ross, Stephen T ^b   Flaim, Kathryn E ^b   Sawyer, John L ^b  

^a Sterlind Drug Inc ^*  (Jamaica)

^b SmithKline Beecham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAZOLE 5 THIOL DERIVATIVE; 1,2,4 TRIAZOLE 3 THIONE DERIVATIVE; 2 BENZIMIDAZOLETHIOL DERIVATIVE; 2 PYRIDINETHIOL DERIVATIVE; 2 PYRIMIDINETHIONE DERIVATIVE; DOPAMINE BETA MONOOXYGENASE; IMIDAZOLINETHIONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMAL; BINDING SITES; CATTLE; CHEMISTRY; CHEMISTRY, PHYSICAL; COPPER; DOPAMINE BETA-HYDROXYLASE; ENZYME INHIBITORS; IMIDAZOLES; IN VITRO; LIGANDS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; THIONES; TRIAZOLES;

EID: 0025058617     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00164a051     Document Type: Article

References (17)

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