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Volumn 335, Issue 8680, 1990, Pages 11-15

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450; RIFAMPICIN;

EID: 0025058297     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(90)90137-T     Document Type: Article
Times cited : (141)

References (23)
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  • 4
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    • Cyclosporine metabolism in human liver identification of a cytochrome P-450 III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • (1988) Clinical Pharmacology and Therapeutics , vol.43 , pp. 630-635
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  • 6
    • 0024603850 scopus 로고
    • Metabolism of cyclosporin A IV: purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
    • (1988) Drug Metab Dis , vol.17 , pp. 197-207
    • Combalbert1    Fabre2    Fabre3
  • 7
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    • Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats
    • (1987) J Clin Invest , vol.80 , pp. 1017-1022
    • Wrighton1    Thomas2    Willis3
  • 8
    • 0022998708 scopus 로고
    • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
    • (1986) J Biol Chem , vol.261 , pp. 5051-5060
    • Guengerich1    Martin2    Beaunne3    Kremers4    Wolff5    Waxman6
  • 10
    • 84920226578 scopus 로고    scopus 로고
    • Pb Watkins, Sa Murray, Pe Thomas, Sa Wrighton, The distribution of cytochromes P-450, cytochromes B5, and NADPH reductase in an entire human liver, Biochem Pharmacol, (in press)).
  • 14
    • 0023854270 scopus 로고
    • Characterization of the common genetic defect in humans defident in debrisoquine metabolism
    • (1988) Nature , vol.331 , pp. 442-446
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  • 18
    • 0024510403 scopus 로고
    • Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction
    • (1989) Gut , vol.30 , pp. 391-396
    • Naoumov1    Tredger2    Steward3
  • 20
    • 84920223099 scopus 로고
    • P-450 III metabolizes cyclosporin A in intestinal mucosa: observations in a novel rat model
    • (1989) Clin Res , vol.37 , pp. 933A
    • Kolars1    Duell2    Benedict3
  • 22
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    • Induction of microsomal cytochrome P-450 enzymes: the first Bernard B. Brodie lecture at Pennsylvania State University
    • (1986) Life Sci , vol.39 , pp. 2493-2518
    • Conney1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.