Precision and sensitivity of pharmacokinetic models for cancer risk assessment: Tetrachloroethylene in mice, rats, and humans

Toxicology and Applied Pharmacology

Volumn 102, Issue 2, 1990, Pages 300-315

  Bois, Frederic Y ^a   Zeise, Lauren ^b   Tozer, Thomas N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b California Department Health Services RCHAS ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETRACHLOROETHYLENE;

ARTICLE; CANCER RISK; FEMALE; HUMAN; MALE; MOUSE; NONBIOLOGICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT;

ANIMAL; FEMALE; HUMAN; MALE; MICE; NEOPLASMS; RATS; RISK; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRACHLOROETHYLENE;

EID: 0025056640     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(90)90029-T     Document Type: Article

References (49)

1. Physiologically based pharmacokinetics and the risk assessment for methylene chloride
2. A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans
3. Quantitative approaches in use to assess cancer risk
4. Methotrexate pharmacokinetics
5. Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk
6. Integrating uncertainty and interindividual variability in environmental risk assessment
7. The use of pharmacokinetic models in the determination of risks for regulatory purposes
8. Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect study
9. Risk assessment extrapolations and physiological modeling
10. The regulation of carcinogens
11. An improved procedure for low dose carcinogenic risk assessment from animal data
12. Dose-response analyses of bone cancers from radium (Letter to the Editor)
13. Metabolic conversion of tri- and tetrachloroethylene: Formation and deactivation of genotoxic intermediates
14. Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity
15. Human styrene exposure
16. Trichloroethylene exposure: Simulation of uptake, excretion, and metabolism using a mathematical model
17. Tetrachloroethylene: Balance and tissue distribution in male Sprague-Dawley rats by drinking water administration
18. From mouse-to-man: The quantitative assessment of cancer risks
19. Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example—vinyl chloride
20. Physiologically based pharmacokinetic modeling: Principles and applications
21. Prioritization of chemical carcinogenesis testing: The use of production data
22. A comparative study of the excretion of Fugiwara reaction-positive substances in urine of humans and rodents given trichloro- or tetrachloro-derivatives of ethane and ethylene
23. Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene
24. Some Halogenated Hydrocarbons
25. A mathematical model of a phantom developed for use in calculations of radiation dose to the body and major internal organs of a Japanese adult
26. Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model
27. Metabolic disposition study of chlorinated hydrocarbons in rats and mice
28. Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene
29. Kinetics of tetrachloroethylene in volunteers; Influence of exposure concentration and work load
30. Estimation of individual uptake of trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene from biological parameters
31. The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat
32. Limited capacity of humans to metabolize tetrachloroethylene
33. 14C)ethylene following oral and inhalation exposure in rats
34. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans
35. Application of pharmacokinetic principles in practice
36. The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity
37. Interspecies extrapolations in risk analysis
38. Pharmacokinetics of tetrachloroethylene
39. Dose-response relationships for carcinogens: A review